Xtandi

Q: Can Xtandi cure cancer?

<p><a href="https://www.withpower.com/clinical-trials/xtandi">Xtandi</a> (<a href="https://www.withpower.com/clinical-trials/enzalutamide">enzalutamide</a>) is a hormone therapy used to treat <a href="https://www.withpower.com/clinical-trials/advanced-prostate-cancer">advanced prostate cancer</a>. It doesn't cure prostate cancer, but can control its progression and spread by slowing it down - often for several years.</p>

Malignant neoplasm of prostate, Malignant Neoplasms

Treatment

11 Active Studies for Xtandi

Treatment for

Malignant neoplasm of prostate

What is Xtandi

EnzalutamideThe Generic name of this drug

Treatment SummaryEnzalutamide is a medication approved by the FDA in 2012 to treat prostate cancer that has stopped responding to other treatments. It works by blocking androgen receptor proteins, which are involved in promoting the growth of certain types of cancer cells.

Xtandiis the brand name

image of different drug pills on a surface

Xtandi Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Xtandi

Enzalutamide

2012

Effectiveness

How Xtandi Affects PatientsEnzalutamide is a drug used to treat prostate cancer that works by blocking testosterone and the hormone receptor that signals its activity. Over time, prostate cancer can become resistant to this treatment, but Enzalutamide was designed to target mutations that occur in these cases. Clinical trials have shown that Enzalutamide can reduce Prostate Specific Antigen (PSA) levels for at least 12 weeks and also decrease the risk of death by 37% compared to a placebo.

How Xtandi works in the bodyEnzalutamide is a drug that helps to stop cancer by blocking the effects of androgens (male hormones) in the body. It prevents androgens from binding to their receptors, from entering the nucleus of cells, and from interacting with DNA. Enzalutamide binds to androgen receptors more strongly than other drugs, and it is more effective at blocking the effects of androgens than the natural hormone dihydrotestosterone. This helps to stop the growth of cancer cells.

When to interrupt dosage

The advocated amount of Xtandi is contingent upon the diagnosed disorder. The exact dosage relies on the approach of administration (e.g. Capsule - Oral or Tablet - Oral) specified in the table below.

Condition

Dosage

Administration

Malignant neoplasm of prostate

, 40.0 mg, 80.0 mg

, Oral, Capsule, Capsule - Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Malignant Neoplasms

, 40.0 mg, 80.0 mg

, Oral, Capsule, Capsule - Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Warnings

There are 20 known major drug interactions with Xtandi.

Common Xtandi Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Enzalutamide.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Enzalutamide.

5-androstenedione

Major

The metabolism of 5-androstenedione can be increased when combined with Enzalutamide.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Enzalutamide.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Enzalutamide.

Xtandi Toxicity & Overdose RiskEnzalutamide can cause birth defects in developing mice when taken in doses of 10 or 30 mg/kg/day. These effects include increased post-implantation loss, birth defects like cleft palate, and decreased anogenital distance. In rats, a single dose of 30 mg/kg caused concentrations of the drug in the fetus that were about 0.3 times the concentration found in the mother's plasma. Studies show that men taking enzalutamide may experience reduction in fertility. Common side effects associated with taking enzalutamide include fatigue, back pain, diarrhea, joint pain, hot flashes, swelling, muscle

image of a doctor in a lab doing drug, clinical research

Xtandi Novel Uses: Which Conditions Have a Clinical Trial Featuring Xtandi?

30 active trials are currently assessing the efficacy of Xtandi in alleviating Castration-related symptoms.

Condition

Clinical Trials

Trial Phases

Malignant neoplasm of prostate

8 Actively Recruiting

Early Phase 1, Phase 2, Not Applicable, Phase 1

Malignant Neoplasms

2 Actively Recruiting

Phase 3, Phase 1

Xtandi Reviews: What are patients saying about Xtandi?

5Patient Review

12/9/2014

Xtandi for Metastatic Castration-Resistant Prostate Cancer

After two months of use, I started feeling strange fatigue. It would come and go; one minute I'd feel perfectly normal, the next I'd have to lie down. Maybe this is just a side effect of getting older (I'm 72), but it's worth mentioning.

5Patient Review

9/21/2020

Xtandi for Metastatic Castration-Resistant Prostate Cancer

I was hospitalized after a bad fall in December 2018. That's when they found out I had prostate cancer that had spread to my bones and lymph nodes. My PSA was over 1000 while I was in the hospital. But after starting Xtandi just two months later, my PSA is now under 1 and holding steady!

5Patient Review

6/29/2013

Xtandi for Metastatic Castration-Resistant Prostate Cancer

5Patient Review

12/4/2020

Xtandi for castration-resistant prostate cancer

I've only been taking Xtandi for 20 days, but my PSA has already dropped from 5.7 to 1.5—amazing!

4Patient Review

7/15/2013

Xtandi for Metastatic Castration-Resistant Prostate Cancer

Xtandi was very effective for me in reducing my PSA levels. Within 3 months, it went from 400 to 5.7. I'm feeling much better now and more like myself again.

View All Reviews

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Patient Q&A Section about xtandi

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Xtandi cure prostate cancer?

"Xtandi is a hormone therapy used to treat advanced prostate cancer. It can't cure prostate cancer, but it can control it by slowing the progression and spread of the disease."

Answered by AI

What are the side effect of Xtandi?

"If you experience any of the following serious side effects while taking Xtandi, tell your doctor immediately: severe low back pain, difficulty walking or standing, weakness in your lower body, severe and worsening numbness or tingling, sudden loss of bladder or bowel control, fever, cough with yellow or green mucus, stabbing chest pain."

Answered by AI

Is Xtandi a form of chemotherapy?

"XTANDI is a drug that inhibits the androgen receptor. Androgens are a group of hormones that includes testosterone. Androgen receptor inhibitors block the androgen receptor so that androgens cannot attach to them. This can help slow cancer cell growth."

Answered by AI

What does the drug Xtandi do?

"XTANDI is a prescription medicine used to treat men with prostate cancer. XTANDI is for men who have cancer that no longer responds to a hormone therapy or surgical treatment to lower testosterone, or who have cancer that has spread to other parts of the body and who respond to a hormone therapy or surgical treatment to lower testosterone."

Answered by AI

How long does Xtandi extend life?

"The AFFIRM trial showed that Xtandi extends life by an average of 5 months. Out of all the people in the trial who were taking Xtandi, the median overall survival time was 18.4 months. This is compared to the placebo group, whose median overall survival time was only 13.6 months. This difference is statistically significant (p<0.001)."

Answered by AI

Can Xtandi cure cancer?

"Xtandi (enzalutamide) is a hormone therapy used to treat advanced prostate cancer. It doesn't cure prostate cancer, but can control its progression and spread by slowing it down - often for several years."

Answered by AI