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What is Tribenzor
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a diuretic medication prescribed to treat fluid retention and high blood pressure. It is the most commonly used thiazide diuretic, but its use is slowly declining in favor of other medications like angiotensin converting enzyme inhibitors. It is often combined with other drugs like angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. The FDA approved Hydrochlorothiazide in 1959.
Esidrixis the brand name
Tribenzor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Stroke and inadequate response to other therapeutic measures .Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Bedrest
Used to treat Bedrest in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Effectiveness
How Tribenzor Affects PatientsHydrochlorothiazide stops the body from reabsorbing sodium and water from the kidneys, which causes the body to get rid of more water in the urine. Doses can vary from person to person and usually range from 25-100mg, but should be used with caution if someone has reduced kidney or liver function.
How Tribenzor works in the bodyHydrochlorothiazide helps reduce water absorption in the body by blocking the way sodium is absorbed in the kidneys. It enters kidney cells using special transporters, then is pumped into the kidney's tubes. Normally, sodium is taken up by these cells and then pumped into the tissue around them, creating a concentration that pulls water in. Hydrochlorothiazide stops the sodium-chloride transporter from working, which reduces the concentration and prevents water absorption.
When to interrupt dosage
The prescribed portion of Tribenzor is contingent on the determined circumstances, for example Antepartum magnesium sulfate prophylaxis, inadequacy in blood pressure control through single therapy and antihypertensives. The quantity of dosage is contingent upon the technique of delivery (e.g. Tablet, coated - Oral or Oral) featured in the table beneath.Condition
Dosage
Administration
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Sodium retention
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Left Ventricular Hypertrophy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Bedrest
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate control of blood pressure with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate response to other therapeutic measures
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
restriction of fluid and sodium
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antihypertensive Treatment
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
blood pressure inadequately controlled with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Tribenzor ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Tribenzor Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Tribenzor Toxicity & Overdose RiskThe most toxic dose of hydrochlorothiazide in mice and rats was found to be greater than 10g/kg. Those who overdose may have low levels of potassium, chloride, and sodium in their blood and may experience symptoms such as hypotension. Treatment includes fluids and electrolytes, vasopressors for low blood pressure, and oxygen for difficulty breathing.
Tribenzor Novel Uses: Which Conditions Have a Clinical Trial Featuring Tribenzor?
Presently, 158 active trials are investigating the utility of Tribenzor in alleviating symptoms of Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Antihypertensive Treatment
0 Actively Recruiting
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Renal tubular acidosis
0 Actively Recruiting
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Diabetes Insipidus
1 Actively Recruiting
Phase 1
hypokalemia with solo treatment
0 Actively Recruiting
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
calcium channel blockers
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 4
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Nephrolithiasis
0 Actively Recruiting
Congestive Heart Failure
23 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
inadequate response to other therapeutic measures
0 Actively Recruiting
Diuretics
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Tribenzor Reviews: What are patients saying about Tribenzor?
5Patient Review
8/13/2014 Though it initially lowered my blood pressure, I began experiencing a number of negative side effects after just three weeks. These included blurry vision, extreme thirst and frequent urination, sore throat, dizziness, and low energy. I stopped taking the medication last week but unfortunately the symptoms have yet to subside.
5Patient Review
2/27/2015 Before I started this medication, I was on Diovan but my blood pressure remained high. However, since starting Tribenzor about a month ago, it has been running between 117/76 to 130/80 - much lower than before. Additionally, I haven't had any negative side effects other than palpitations in the first few days after starting the medication when my BP was still very high.
5Patient Review
4/22/2016 Tribenzor lowered my blood pressure to a much healthier range. I'm feeling great and owe it all to this medication.
5Patient Review
3/15/2014 I was facing extreme hair loss, cold-like symptoms every month, swelling in my hands and feet, and chronic thirstiness and headaches.
4.3Patient Review
5/31/2015 I've been using this medication for three weeks and it has effectively lowered my blood pressure back to a healthy level. Prior to taking this, my blood pressure was running high (165/80 or less) for about a month straight. I'd been on Diovan HCT for over 10 years at that point, so I think I just needed a change. Fingers crossed that this keeps working as well as it has been!
4Patient Review
11/21/20134Patient Review
12/22/20133.7Patient Review
10/15/2014 Though this treatment effectively lowered my blood pressure, I began to experience some serious side effects. These included dizziness, lightheadedness, confusion, and an intense craving for fresh fruit. Thankfully, I was able to receive medical attention in time and made a full recovery.
3.7Patient Review
3/17/2014 So far, I've been pleased with this medication. It's lowered my blood pressure without any noticable side effects. However, the cost is definitely a concern of mine.
3Patient Review
9/15/2014 If you're allergic to sulfur, don't take this drug. I had a severe reaction all over my body.
3Patient Review
4/6/2014 My blood pressure has been great since starting this medication, but I have noticed that I tend to get dry mouth at night.
2.7Patient Review
2/6/2017 I tried Tribenzor for two weeks. I was also on a diabetic pill which is not supposed to be taken together. Tribenzor will mask your sugar dropping, this also made me nervous, nausea, joint pain. Doctor has recently switched my bp med. This did how ever keep my bp down. I couldn't handle the side effects
2.7Patient Review
8/18/2014 I didn't have any success with Benicare, but Trebenzor was a different story. My blood pressure went down quickly and stayed low for most of the day. I also stopped having issues with excessive urination. Overall, I would recommend this medication.
2.3Patient Review
7/14/2014 I've now been on this medication for a month and I have experienced some serious side effects, including but not limited to: leg cramps, shoulder pain, neck pain, and fatigue. My blood pressure has also been all over the place. I'm going to speak to my doctor tomorrow about potentially halving my dose.
2Patient Review
7/21/2014 I didn't find this treatment very effective for my neck pain.
1.3Patient Review
1/30/2014 I have been on tribenzor for 8 months. My blood pressure went down, but I began to experience dizziness, shortness of breath, and fatigue. Additionally, I had shoulder and joint pain. Sometimes I feel like I'm going to faint. Overall, not a great experience.
1Patient Review
3/28/2016 I haven't had any issues with this medication for a year now, and my blood pressure has been really well-controlled the entire time.
Patient Q&A Section about tribenzor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class of drug is Tribenzor?
"Tribenzor is a combination of an angiotensin receptor blocker, a calcium channel blocker, and a diuretic used to treat high blood pressure."
Answered by AI
What is Tribenzor used for?
"This product is for treating high blood pressure. By lowering high blood pressure, it helps prevent strokes, heart attacks, and kidney problems. Olmesartan, amlodipine, and hydrochlorothiazide are the 3 medications in this product."
Answered by AI
Is Tribenzor a good medication?
"Tribenzor is a safe way to lower blood pressure. It has more side effects and drug interactions than other methods, so it should only be used as directed by a provider."
Answered by AI
What is the generic for Tribenzor?
"The drugs olmesartan medoxomil, amlodipine, and hydrochlorothiazide, taken together, are indicated for the treatment of hypertension. This drug combination reduces blood pressure, which in turn reduces the risk of cardiovascular events such as strokes and heart attacks."
Answered by AI