Daptomycin vs. Vancomycin for Staph Bacteremia
(DAPTO-SNAP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This is an open label randomized controlled trial for patients with methicillin resistant S. aureus (MRSA) bloodstream infection which will directly compare the two most commonly used therapies, vancomycin and daptomycin.This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119)
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is daptomycin safe compared to vancomycin for treating bacterial infections?
How does the drug Daptomycin differ from Vancomycin for treating Staph bacteremia?
Daptomycin is a newer antibiotic that can be used as an alternative to Vancomycin, especially when the bacteria show reduced sensitivity to Vancomycin. It is particularly useful for patients with kidney issues, as Vancomycin can be toxic to the kidneys, and for treating infections with high Vancomycin minimum inhibitory concentrations.35678
What data supports the effectiveness of the drug Daptomycin for treating Staph bacteremia?
Who Is on the Research Team?
Todd C Lee, MD MPH FIDSA
Principal Investigator
McGill University Health Centre/Research Institute of the McGill University Health Centre
Are You a Good Fit for This Trial?
This trial is for patients with a serious blood infection caused by a bacteria called methicillin-resistant Staphylococcus aureus (MRSA). It's open to those who haven't been treated yet. Specific eligibility details are not provided, but typically participants need to meet certain health standards.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either daptomycin or vancomycin for the treatment of MRSA bacteremia
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Daptomycin
- Vancomycin
Daptomycin is already approved in European Union, United States, Canada, Japan for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Todd C. Lee MD MPH FIDSA
Lead Sponsor
The Peter Doherty Institute for Infection and Immunity
Collaborator
University of Melbourne
Collaborator