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What is Tradjenta
LinagliptinThe Generic name of this drug
Treatment SummaryLinagliptin is a medication used to treat type II diabetes. It works differently than other similar medications by having a non-linear effect on the body and not being eliminated by the kidneys. It was approved by the FDA in 2011 and is sold under the brand name Tradjenta.
Tradjentais the brand name
Tradjenta Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tradjenta
Linagliptin
2011
17
Approved as Treatment by the FDA
Linagliptin, also known as Tradjenta, is approved by the FDA for 3 uses like Physical Activity and Type 2 Diabetes .Physical Activity
Used to treat Exercise in combination with Empagliflozin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Empagliflozin
Diet
Used to treat Diet in combination with Empagliflozin
Effectiveness
How Tradjenta Affects PatientsTaking 5mg of linagliptin helps to reduce blood sugar levels by blocking an enzyme (DPP-4) in the body for 24 hours or more. This blocking of the enzyme increases the amount of a hormone (GLP-1) that helps to lower levels of sugar in the blood and reduce sugar in the blood when fasting.
How Tradjenta works in the bodyLinagliptin is a drug that prevents an enzyme called DPP-4 from breaking down certain proteins in the body. These proteins, GLP-1 and GIP, work to stimulate the release of insulin from the pancreas. This increases the amount of insulin released in response to glucose, and decreases the breakdown of glycogen in the liver.
When to interrupt dosage
The prescribed dose of Tradjenta hinges upon the indicated condition, such as Physical Activity, Diet and Type 2 Diabetes. The measure of dosage is based on the administration approach (e.g. Tablet - Oral or Tablet) specified in the table hereunder.Condition
Dosage
Administration
Diet
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Type 2 Diabetes
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Physical Activity
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Warnings
Tradjenta has six contraindications, and it should not be taken while enduring any of the conditions specified in the table below.Tradjenta ContraindicationsCondition
Risk Level
Notes
Acute Coryza
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Metabolic acidosis
Do Not Combine
Dialysis therapy
Do Not Combine
Kidney Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Linagliptin may interact with Pulse Frequency
Common Tradjenta Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Linagliptin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Linagliptin.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Linagliptin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Linagliptin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Linagliptin.
Tradjenta Toxicity & Overdose RiskLinagliptin is suitable for use in people of all ages, genders, weights, and races, as well as those with kidney or liver problems. Clinical trials have shown that people aged 10-18 can take linagliptin without any major side effects. Animal studies have suggested a higher risk of lymphoma in female rats who are given doses over 200 times the recommended amount for humans. Linagliptin has also been found to be non-mutagenic, non-clastogenic, and not to affect fertility.
Tradjenta Novel Uses: Which Conditions Have a Clinical Trial Featuring Tradjenta?
196 active trials are being conducted to assess the potential of Tradjenta in promoting Physical Activity, managing Type 2 Diabetes and Diet modification.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Diet
5 Actively Recruiting
Not Applicable
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Tradjenta Reviews: What are patients saying about Tradjenta?
5Patient Review
7/14/2018 After a two week trial, my blood sugar readings were very good. I was able to switch from taking insulin before each meal to just once a day. Trajenta and one shot of long lasting insulin per day has been working great for me.
5Patient Review
2/12/2020 I've been taking this drug for about a year with great results. My A1C dropped two points and I couldn't be happier. Now my insurance doesn't want to cover it, so I'm trying something new which makes me very nervous.
5Patient Review
1/5/2019 This treatment is effective and has no negative side effects that I've experienced.
3.7Patient Review
7/3/2016 I noticed that my sugar levels have been elevated since taking this medication. I also experienced increased mucus production, which I never would have attributed to the tradjenta if it weren't for reading other reviews. It's quite expensive, though.
3.3Patient Review
4/28/2019 I often wake up with pain in my mid-back, but it goes away once I get out of bed. Has anyone else experienced something similar?
3Patient Review
5/17/2017 I've been taking this medication for a month and have not seen the results I was hoping for. My levels are still pretty high, even after diet and exercise changes. I'm also having some abdominal issues that are concerning me. I'll be discussing all of this with my doctor at my follow-up appointment this Friday.
3Patient Review
5/24/2019 After using this medication for three months, I have decided to discontinue use. The severe side effects (including but not limited to: sore throat, cough, muscle pain, abdominal pain radiating to my back, and difficulty sleeping due to said pain) outweigh any potential benefits.
3Patient Review
12/14/2019 I switched to Forxiga 10mg about six months ago, but I haven't seen any real effect on my diabetes.
2.3Patient Review
5/30/2017 I was pleased when my physician recently added this medication to my metformin and lantus regimen. However, I'm almost surprised that I'm getting it because it's very expensive. My glucose numbers have been way above normal lately, and I guess I wanted to believe that I could get away with being less strict with my diet. From what I can see, this drug is not highly effective. You would be better off spending the money on a gym membership than this expensive ineffective medication, in my opinion.
2.3Patient Review
9/19/2017 I've found that my blood sugar has been elevated since taking this medication, and I've also started to experience abdominal pain. In my opinion, it's not effective at all.
2.3Patient Review
2/10/2018 I'm not sure this medication is doing what it's supposed to. I've been on it for six weeks now, and my numbers are higher than when I started.
2.3Patient Review
12/30/2016 Despite using this medication for a couple of years, it never worked for me. My A1C readings are still high. This is an expensive medication with no results to show for it.
2.3Patient Review
9/24/2022 After taking this medication, my A1c level rose significantly. I don't think my doctor should have put me on it.
2Patient Review
11/21/2016 I had to stop taking metformin due to explosive stomach issues. Doc put me on this med instead. After 1 1/2 months there are no side effects and my blood sugar has risen considerably; however, it is an expensive medication that did nothing for me.
1.3Patient Review
7/25/2022 I got very sick after only taking this medication for three days. Vomiting and diarrhea made me never want to take this drug again.
1Patient Review
1/13/2017 I only took this for a week and a half before I realized the potential severity of the side effects. I experienced abdominal pain and pancreatitis within days of taking it, despite paying nearly $400 for the prescription. Needless to say, I won't be taking this medication again.
1Patient Review
10/9/2017 I took this medicine for a month and a half. My heart started racing, shortness of breath lightheadedness and tightness in my throat I also was sweating like crazy.
1Patient Review
1/13/2018 I've been taking this medicine for 3 months and my glucose test results have stayed consistently high, even when fasting in the morning. My current doctor insists I continue taking it, but I don't see the point anymore and am changing to a new one.
1Patient Review
11/10/2018 This medication helped me for the first three months, but now it's not lowering my glucose levels and I'm having a lot of congestion. I wouldn't start it again.
1Patient Review
8/15/2018 My diabetes has gotten worse since my doctor put me on this medication. I was doing fine at 7.0, but now I'm averaging above 12.5 and I don't feel like this drug is helping me at all.
Patient Q&A Section about tradjenta
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Tradjenta the same as metformin?
"Tradjenta may help to lower blood sugar levels, but may cause bodily aches. Glucophage is a medication that is typically used to help control blood sugar levels and lower the risk of death from diabetes, but a few people may not be able to tolerate the stomach side effects."
Answered by AI
What is the drug Tradjenta used for?
"If you have type 2 diabetes, your body does not make or use insulin well. Insulin is a hormone that helps glucose get into your cells to give them energy. Tradjenta (linagliptin) is an oral diabetes medicine that helps control blood sugar levels by stimulating the release of insulin after a meal. Tradjenta is for people with type 2 diabetes. It is sometimes used in combination with other diabetes medications.
If you have type 2 diabetes, your body doesn't process insulin as effectively as it should. Insulin is a hormone that helps glucose get into your cells to give them energy. Tradjenta (linagliptin) is an oral diabetes medication that helps control blood sugar levels by stimulating the release of insulin after a meal. Tradjenta is for people with type 2 diabetes and is sometimes used in combination with other diabetes medications."
Answered by AI
Is Tradjenta and Januvia the same thing?
"Tradjenta works by regulating the levels of insulin your body produces after eating.
Are Januvia and Tradjenta the same medication?
Januvia (sitagliptin) and Tradjenta (linagliptin) are oral diabetes medicines for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Tradjenta works by regulating the levels of insulin your body produces after eating."
Answered by AI
What is the side effect of Tradjenta?
"Potential side effects of this medication may include a runny or stuffy nose, a sore throat, a cough, or diarrhea."
Answered by AI