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Rapid Treatment Approach for Chronic Kidney Disease

(RAPID-CKD Trial)

SK
Overseen ByShahzeb Khan, MD
Age: 18+
Sex: Any
Trial Phase: Phase 4
Sponsor: Baylor Research Institute
Must not be taking: High dose insulin
Disqualifiers: Type 1 diabetes, Liver disease, Brittle diabetes, Active malignancy, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this clinical trial is to learn if starting four kidney disease medicines quickly and together (a rapid treatment approach) is safe and works well in people with type 2 diabetes and chronic kidney disease.

The main questions it aims to answer are:

* Is it safe to start these medicines over a short period of time?

* How often do kidney function changes or high potassium levels occur?

* Does this approach lower protein in the urine (a sign of kidney damage)?

* How many participants are able to stay on all four medicines over 6 months?

Researchers will compare this approach to usual care, where medicines are started one at a time over several months.

Participants will:

Be assigned by chance to either this approach or usual care Start up to four approved kidney medicines over about 8 weeks (rapid treatment approach) or follow standard care Have regular clinic visits and lab tests to check kidney function and potassium levels Be followed for about 6 months

Are You a Good Fit for This Trial?

Inclusion Criteria

UACR >200 mg/g
I am between 18 and 84 years old.
Systolic BP (SBP) >90 mmHg
See 5 more

Exclusion Criteria

Type 1 diabetes
Life expectancy <6 months
ns-MRA: hyperkalemia
See 13 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive up to four approved kidney medicines over approximately 8 weeks in a rapid treatment approach

8 weeks
Regular clinic visits and lab tests

Follow-up

Participants are monitored for safety and effectiveness after treatment, including kidney function and potassium levels

6 months
Regular clinic visits and laboratory testing

What Are the Treatments Tested in This Trial?

Interventions

  • Capoten
  • Enalapril
  • Lotensin
  • Monopril

How Is the Trial Designed?

2

Treatment groups

Active Control

Group I: Control GroupActive Control25 Interventions
Group II: Interventional GroupActive Control25 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Baylor Research Institute

Lead Sponsor

Trials
210
Recruited
205,000+

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