Alternating-Frequency DBS for Parkinson's Disease
(ENGAGE-PD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a new type of brain stimulation that changes how often electrical signals are sent to the brain. It aims to help Parkinson's Disease patients who have trouble with balance and walking, problems that current treatments can't fix. By adjusting the stimulation pattern, researchers hope to improve these movement issues.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What is the safety profile of Deep Brain Stimulation (DBS) for Parkinson's Disease?
How is Alternating-Frequency DBS different from other treatments for Parkinson's Disease?
What data supports the effectiveness of the treatment Alternating-Frequency DBS for Parkinson's Disease?
Research suggests that varying the frequency of deep brain stimulation (DBS) can help manage different motor symptoms in Parkinson's disease. For example, combining high and low frequencies in DBS has shown potential to address a wider range of symptoms, such as tremors and movement difficulties.6891011
Who Is on the Research Team?
James Liao, MD PhD
Principal Investigator
The Cleveland Clinic
Are You a Good Fit for This Trial?
This trial is for people with Parkinson's Disease who have a specific type of brain stimulation device implanted and struggle with balance or walking but can still walk without help. They shouldn't need a walker or cane, have other conditions affecting their gait, be under 21, diagnosed with dementia, or object to being filmed during the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants perform a gait task using a new, alternating DBS frequency paradigm while body movements and neural signals are recorded
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Alternating-Frequency DBS
Alternating-Frequency DBS is already approved in European Union, United States, Canada, Japan for the following indications:
- Parkinson's disease
- Essential tremor
- Dystonia
- Obsessive-compulsive disorder
- Tourette syndrome
- Treatment-resistant depression
- Parkinson's disease
- Essential tremor
- Dystonia
- Obsessive-compulsive disorder
- Epilepsy
- Parkinson's disease
- Essential tremor
- Dystonia
- Parkinson's disease
- Essential tremor
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Cleveland Clinic
Lead Sponsor
James Liao
Lead Sponsor