Ticlid

Thrombosis, Stroke, Coronary Stent Implantation + 5 more
Treatment
5 FDA approvals
10 Active Studies for Ticlid

What is Ticlid

TiclopidineThe Generic name of this drug
Treatment SummaryTiclopidine, sold under the brand name Ticlid, is a medication used to prevent thrombotic strokes in people who cannot take aspirin or have not responded to aspirin. It works by blocking the ADP receptor involved in platelet aggregation. However, it has a black-box warning for decreased white blood cell and platelet counts, so it is necessary to monitor these levels when taking ticlopidine.
Ticlidis the brand name
image of different drug pills on a surface
Ticlid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ticlid
Ticlopidine
1991
9

Approved as Treatment by the FDA

Ticlopidine, otherwise called Ticlid, is approved by the FDA for 5 uses including Thrombosis (Stent Thrombosis) and Stroke .
Thrombosis (Stent Thrombosis)
Stroke
Coronary Stent Implantation
Thrombosis
subacute stent thrombosis

Effectiveness

How Ticlid Affects PatientsTiclopidine is a drug that is changed in the body into a different form that stops blood cells called platelets from clumping together. This reduces the time it takes for bleeding to stop when an injury occurs. In its original form, ticlopidine does not have any effect at the levels typically found in the body.
How Ticlid works in the bodyTiclopidine works by preventing a molecule called ADP from binding to platelets. Normally, ADP would activate a receptor on the platelet which would cause it to bind to fibrinogen, leading to platelet aggregation. Ticlopidine stops this process from taking place, preventing platelets from clumping together and causing blockages in the blood vessels. Even when platelets are activated by other substances, ticlopidine still works to inhibit the process.

When to interrupt dosage

The proposed amount of Ticlid is contingent upon the diagnosed state, such as Stroke, Stent, device and experienced stroke precursors. Dosage also relies upon the technique of delivery as per the table below.
Condition
Dosage
Administration
Thrombosis
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Coronary Stent Implantation
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Thrombotic Stroke
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
subacute stent thrombosis
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
aspirin
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
experienced stroke precursors
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Ticlid has seven contraindications and should not be used when experiencing any of the conditions mentioned in the table below.Ticlid Contraindications
Condition
Risk Level
Notes
Anemia, Aplastic
Do Not Combine
Neutropenia
Do Not Combine
Hemostatic Disorders
Do Not Combine
Thrombocytopenic purpura
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Low Platelet Count
Do Not Combine
Hemorrhage
Do Not Combine
There are 20 known major drug interactions with Ticlid.
Common Ticlid Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Ticlopidine is combined with Abrocitinib.
Albendazole
Major
The metabolism of Albendazole can be decreased when combined with Ticlopidine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ticlopidine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Ticlopidine.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Ticlopidine.
Ticlid Toxicity & Overdose RiskTiclopidine is a very toxic drug, as 1600 mg/kg and 500 mg/kg doses have been found to be fatal for rats and mice. Symptoms of overdose include bleeding in the stomach and intestines, seizures, low body temperature, difficulty breathing, and trouble walking. Patients taking ticlopidine should be monitored for low white blood cell count and platelet count, as these side effects can be severe.
image of a doctor in a lab doing drug, clinical research

Ticlid Novel Uses: Which Conditions Have a Clinical Trial Featuring Ticlid?

17 active trials are currently evaluating the potential of Ticlid in treating subacute stent thrombosis, Coronary Stent Implantation and post-stroke conditions.
Condition
Clinical Trials
Trial Phases
subacute stent thrombosis
0 Actively Recruiting
Coronary Stent Implantation
0 Actively Recruiting
Stroke
9 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Thrombosis
0 Actively Recruiting
Stroke
0 Actively Recruiting
experienced stroke precursors
0 Actively Recruiting
Thrombotic Stroke
1 Actively Recruiting
Not Applicable
aspirin
0 Actively Recruiting

Ticlid Reviews: What are patients saying about Ticlid?

3.3Patient Review
6/22/2009
Ticlid for Treatment to Prevent a Blood Clot in a Vascular Stent
About six weeks ago, I had a stent placed. A few weeks after that, I had a severe reaction to the Plavix medication. All of this happened within seven hours of going to bed. Since then, I've been having issues with dizziness and sinus problems. I'm not sure if they're related, but it's been quite unpleasant nonetheless.
3Patient Review
4/28/2009
Ticlid for Blood Clot Prevention Following Percutaneous Coronary Intervention
Ever since I started taking Ticlid, I've had nonstop diarrhea (up to 9 times a day). It's been 3-4 weeks now and there's no sign of it letting up.
2.3Patient Review
8/14/2008
Ticlid for Treatment to Prevent a Blood Clot in a Vascular Stent
The intended use is adequate. However, I question the effects of tooth extraction.
2Patient Review
1/18/2008
Ticlid for Treatment to Prevent a Blood Clot in a Vascular Stent
I bruise easily, and I'm constantly dealing with itchy rashes. Plavix isn't an option for me.
1Patient Review
10/5/2011
Ticlid for Treatment to Prevent a Blood Clot in a Vascular Stent
Since starting this medication, I have experienced burning sensations in my hands and feet, aches in my joints, fatigue, mood swings, and hearing problems. My liver enzymes are also elevated.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ticlid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Ticlid?

"Antiplatelet drugs like Ticlopidine help to reduce the risk of thrombotic strokes by inhibiting the binding of ADP to its receptor."

Answered by AI

What is Ticlid used for?

"Ticlid is a drug that inhibits platelet aggregation, which is used to prevent blood clots after a recent heart attack or stroke, or in people with certain disorders of the heart or blood vessels."

Answered by AI

Why was Ticlid discontinued?

"Ticlopidine is a drug that was approved for use in the United States in 1991. However, it is not often used now because of the serious risks of side effects like agranulocytosis, thrombotic thrombocytopenic purpura, and aplastic anemia. There is also another drug, clopidogrel, that has a similar effect and is available."

Answered by AI

What class of drug is Ticlid?

"Ticlid is a drug that is used to prevent blood clots. It is part of a class of drugs called antiplatelet agents. It is not known if Ticlid is safe and effective in children younger than 18 years of age."

Answered by AI

Clinical Trials for Ticlid

Have you considered Ticlid clinical trials? We made a collection of clinical trials featuring Ticlid, we think they might fit your search criteria.
Have you considered Ticlid clinical trials? We made a collection of clinical trials featuring Ticlid, we think they might fit your search criteria.
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