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What is Ticlid
TiclopidineThe Generic name of this drug
Treatment SummaryTiclopidine, sold under the brand name Ticlid, is a medication used to prevent thrombotic strokes in people who cannot take aspirin or have not responded to aspirin. It works by blocking the ADP receptor involved in platelet aggregation. However, it has a black-box warning for decreased white blood cell and platelet counts, so it is necessary to monitor these levels when taking ticlopidine.
Ticlidis the brand name
Ticlid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ticlid
Ticlopidine
1991
9
Approved as Treatment by the FDA
Ticlopidine, otherwise called Ticlid, is approved by the FDA for 4 uses including Stroke and subacute stent thrombosis .Stroke
subacute stent thrombosis
Thrombosis
Coronary Stent Implantation
Effectiveness
How Ticlid Affects PatientsTiclopidine is a drug that is changed in the body into a different form that stops blood cells called platelets from clumping together. This reduces the time it takes for bleeding to stop when an injury occurs. In its original form, ticlopidine does not have any effect at the levels typically found in the body.
How Ticlid works in the bodyTiclopidine works by preventing a molecule called ADP from binding to platelets. Normally, ADP would activate a receptor on the platelet which would cause it to bind to fibrinogen, leading to platelet aggregation. Ticlopidine stops this process from taking place, preventing platelets from clumping together and causing blockages in the blood vessels. Even when platelets are activated by other substances, ticlopidine still works to inhibit the process.
When to interrupt dosage
The proposed amount of Ticlid is contingent upon the diagnosed state, such as Stroke, Stent, device and experienced stroke precursors. Dosage also relies upon the technique of delivery as per the table below.Condition
Dosage
Administration
Coronary Stent Implantation
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
previous stroke
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
experienced stroke precursors
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Thrombotic Stroke
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Thrombosis
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
subacute stent thrombosis
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
aspirin
, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Ticlid has seven contraindications and should not be used when experiencing any of the conditions mentioned in the table below.Ticlid ContraindicationsCondition
Risk Level
Notes
history of aplastic anemia
Do Not Combine
Neutropenia
Do Not Combine
Hemostatic Disorders
Do Not Combine
Thrombocytopenic purpura
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Low Platelet Count
Do Not Combine
Hemorrhage
Do Not Combine
Common Ticlid Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Ticlopidine is combined with Abrocitinib.
Albendazole
Major
The metabolism of Albendazole can be decreased when combined with Ticlopidine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ticlopidine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Ticlopidine.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Ticlopidine.
Ticlid Toxicity & Overdose RiskTiclopidine is a very toxic drug, as 1600 mg/kg and 500 mg/kg doses have been found to be fatal for rats and mice. Symptoms of overdose include bleeding in the stomach and intestines, seizures, low body temperature, difficulty breathing, and trouble walking. Patients taking ticlopidine should be monitored for low white blood cell count and platelet count, as these side effects can be severe.
Ticlid Novel Uses: Which Conditions Have a Clinical Trial Featuring Ticlid?
17 active trials are currently evaluating the potential of Ticlid in treating subacute stent thrombosis, Coronary Stent Implantation and post-stroke conditions.Condition
Clinical Trials
Trial Phases
Thrombosis
0 Actively Recruiting
Coronary Stent Implantation
0 Actively Recruiting
experienced stroke precursors
0 Actively Recruiting
previous stroke
0 Actively Recruiting
subacute stent thrombosis
0 Actively Recruiting
aspirin
0 Actively Recruiting
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Thrombotic Stroke
0 Actively Recruiting
Ticlid Reviews: What are patients saying about Ticlid?
3.3Patient Review
6/22/2009 About six weeks ago, I had a stent placed. A few weeks after that, I had a severe reaction to the Plavix medication. All of this happened within seven hours of going to bed. Since then, I've been having issues with dizziness and sinus problems. I'm not sure if they're related, but it's been quite unpleasant nonetheless.
3Patient Review
4/28/2009 Ever since I started taking Ticlid, I've had nonstop diarrhea (up to 9 times a day). It's been 3-4 weeks now and there's no sign of it letting up.
2.3Patient Review
8/14/2008 The intended use is adequate. However, I question the effects of tooth extraction.
2Patient Review
1/18/2008 I bruise easily, and I'm constantly dealing with itchy rashes. Plavix isn't an option for me.
1Patient Review
10/5/2011 Since starting this medication, I have experienced burning sensations in my hands and feet, aches in my joints, fatigue, mood swings, and hearing problems. My liver enzymes are also elevated.
Patient Q&A Section about ticlid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name for Ticlid?
"Antiplatelet drugs like Ticlopidine help to reduce the risk of thrombotic strokes by inhibiting the binding of ADP to its receptor."
Answered by AI
What is Ticlid used for?
"Ticlid is a drug that inhibits platelet aggregation, which is used to prevent blood clots after a recent heart attack or stroke, or in people with certain disorders of the heart or blood vessels."
Answered by AI
Why was Ticlid discontinued?
"Ticlopidine is a drug that was approved for use in the United States in 1991. However, it is not often used now because of the serious risks of side effects like agranulocytosis, thrombotic thrombocytopenic purpura, and aplastic anemia. There is also another drug, clopidogrel, that has a similar effect and is available."
Answered by AI
What class of drug is Ticlid?
"Ticlid is a drug that is used to prevent blood clots. It is part of a class of drugs called antiplatelet agents. It is not known if Ticlid is safe and effective in children younger than 18 years of age."
Answered by AI