Cardiac Imaging to Predict Embolic Stroke
Trial Summary
What is the purpose of this trial?
Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic stroke using imaging criteria that reflect the underlying pathophysiology of embolic stroke of cardiac origin. the investigators can therefore lay the groundwork for future anticoagulation strategies for stroke prevention beyond AF.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Cardiac and Brain MRI in predicting embolic stroke?
Cardiac MRI is highly effective in assessing heart function and structure, which can help identify heart-related issues that might lead to strokes. It provides detailed images of the heart and blood vessels, helping doctors understand conditions like heart disease and blood flow problems that could contribute to stroke risk.12345
Is cardiac and brain MRI safe for humans?
How is the treatment 'Cardiac and Brain MRI' unique for predicting embolic stroke?
Cardiac and Brain MRI is unique because it provides a non-invasive, three-dimensional view of both the heart and brain, allowing for detailed assessment of cardiovascular and neurological structures without exposure to radiation. This comprehensive imaging approach can help identify potential sources of embolic stroke by evaluating heart function and detecting abnormalities that other imaging techniques might miss.3461011
Research Team
Nassir Marrouche, MD
Principal Investigator
Tulane School of Medicine
Eligibility Criteria
This trial is for adults over 18 without atrial fibrillation but with a high stroke risk score (CHA2DS2VASC ≥3), type II diabetes, or history of heart failure/TIA/stroke from unknown causes. It excludes those who've had recent strokes, are allergic to MRI contrast agents, have certain implants, severe kidney disease, weigh over 300 lbs, or are pregnant/breastfeeding.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Imaging Assessment
Participants undergo Cardiac Magnetic Resonance imaging (CMR) and brain MRI to assess for markers of LA and LAA pathology and embolic-appearing brain infarcts
Data Analysis
Analysis of cardiac imaging features and their association with embolic-appearing strokes on brain MRI
Follow-up
Participants are monitored for safety and effectiveness after imaging assessment
Treatment Details
Interventions
- Cardiac and Brain MRI
Cardiac and Brain MRI is already approved in European Union, United States, Canada, Japan for the following indications:
- Diagnostic imaging for cardiovascular diseases
- Stroke risk assessment
- Diagnostic imaging for cardiovascular diseases
- Stroke risk assessment
- Neurological disorders
- Diagnostic imaging for cardiovascular diseases
- Stroke risk assessment
- Diagnostic imaging for cardiovascular diseases
- Stroke risk assessment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Tulane University
Lead Sponsor