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What is Tekturna
AliskirenThe Generic name of this drug
Treatment SummaryAliskiren is a medication used to treat high blood pressure. It was developed by Speedel and Novartis and approved by the FDA in 2007. Aliskiren works by blocking an enzyme known as renin and can be used on its own or in combination with other medications to reduce blood pressure.
Tekturnais the brand name
Tekturna Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tekturna
Aliskiren
2007
36
Approved as Treatment by the FDA
Aliskiren, also known as Tekturna, is approved by the FDA for 2 uses including Hypertensive disease and not adequately controlled with monotherapy .Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Amlodipine
not adequately controlled with monotherapy
Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide
Effectiveness
How Tekturna Affects PatientsAliskiren lowers blood pressure by blocking the enzyme renin. This has a chain reaction that results in lower blood pressure, which can help prevent life-threatening and non-deadly cardiovascular issues such as stroke and heart attack.
How Tekturna works in the bodyAliskiren is a drug that helps lower blood pressure by blocking the action of a protein called renin. Normally, when blood volume and renal perfusion decrease, renin is released from the kidneys. Renin then turns a protein called angiotensinogen into angiotensin I, which is then converted to angiotensin II. Angiotensin II is a hormone that causes blood vessels to constrict, which increases blood pressure. Aliskiren works by binding to renin and preventing it from turning angiotensinogen into angiotensin I, thereby stopping the release of angiotensin II
When to interrupt dosage
The amount of Tekturna is subject to the diagnosed state. The dosage amount shifts as per the system of delivery (e.g. Oral or Tablet, film coated) provided in the table beneath.Condition
Dosage
Administration
Hypertensive disease
300.0 mg, 150.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
not adequately controlled with monotherapy
300.0 mg, 150.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Tekturna has four counterindications and should not be ingested when confronting any of the conditions given in the following table.Tekturna ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Type 2 Diabetes
Do Not Combine
Type 2 Diabetes
Do Not Combine
Common Tekturna Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Aliskiren may increase the hypotensive activities of Amifostine.
Azilsartan medoxomil
Major
Aliskiren may increase the hypotensive and hyperkalemic activities of Azilsartan medoxomil.
Benazepril
Major
The risk or severity of hypotension, hyperkalemia, and nephrotoxicity can be increased when Aliskiren is combined with Benazepril.
Benazeprilat
Major
The risk or severity of hypotension, hyperkalemia, and nephrotoxicity can be increased when Aliskiren is combined with Benazeprilat.
Captopril
Major
The risk or severity of hypotension, hyperkalemia, and nephrotoxicity can be increased when Aliskiren is combined with Captopril.
Tekturna Toxicity & Overdose RiskThe lowest toxic dose of aliskiren in rats has been found to be greater than 2000mg/kg. If someone takes too much aliskiren, they may experience low blood pressure, and should receive supportive treatment.
Tekturna Novel Uses: Which Conditions Have a Clinical Trial Featuring Tekturna?
18 active studies are currently investigating the potential of Tekturna in ameliorating Hypertensive diseases.Condition
Clinical Trials
Trial Phases
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
not adequately controlled with monotherapy
0 Actively Recruiting
Tekturna Reviews: What are patients saying about Tekturna?
5Patient Review
8/13/2015 I've been on Tekturna for four years now and it's helped me immensely with my high blood pressure and protein loss due to kidney disease. I've tried many other medications, but this one is by far the most effective. The downside is that I'm always tired and have lost some hair, but all medications come with side effects.
5Patient Review
8/30/2012 I've been on this medication for a few years now with no issues. I just recently started having some problems with blood sugar, but I'm not sure if it's related to the Tekturna or not. The other drugs prescribed for high blood pressure always made me exhausted and I would constantly wake up during the night, but Tekturna has helped me sleep better.
5Patient Review
9/25/20115Patient Review
6/5/2013 Tekturna has been a life-saver for me. For the last five years, it's kept my blood pressure in check with no known side effects. It is expensive, but to me, it's worth every penny because I don't have to deal with fatigue like I did with other medications.
4.3Patient Review
4/14/2015 I've been using Tekturna for eight years now and it's kept my blood pressure in check with few side effects. I'm glad the price has gone down recently, as it was getting pretty expensive.
4Patient Review
12/7/2011 I've only been on this medication for a week, but my doctor prescribed it to me in order to lower my protein level due to kidney failure. So far, I haven't noticed any significant changes.
3.7Patient Review
2/12/2012 Cardiologist took me off Tekturna due to severe hoarseness, heartburn, and flu-like symptoms. My Cardiologist told me that this drug was being taken off the market.
3.7Patient Review
12/14/2011 I was dealing with some serious swelling in my ankles that was radiating upwards and causing muscle spasms.
3.3Patient Review
3/15/2012 I experienced severe acid reflux, stomach cramps & painful gas, a salty taste in my mouth, confusion & dizziness when moving. My muscles cramped up so badly I couldn't lift anything more than a piece of paper. The cramps would last till the next morning, at which time I'd take another pill. But no more for me. So glad my doctor recognized these symptons and that I'm on the road to recovery.
3Patient Review
1/28/2012 So far, this medication has not lowered my blood pressure.
2.7Patient Review
1/19/2012 I had a really bad reaction to Tekturna. My blood pressure spiked incredibly high and I developed terrible headaches, dizziness, and fatigue. Definitely not worth it.
2.7Patient Review
7/9/2012 I started losing large amounts of hair and it's really worrying me. My doctor doesn't know about this side effect, but it's getting worse.
2.3Patient Review
12/27/2011 While this drug has been helpful in controlling my blood pressure, it has unfortunately also caused erectile dysfunction. This is apparently a very common side effect of the medication, so I have decided to stop taking it.
2.3Patient Review
9/25/20112.3Patient Review
12/17/2011 While this medicine has helped me in some ways, I have found that it zaps my energy levels.
1.3Patient Review
1/13/2012 I found myself with a sore throat, tired more so than usual, cough that is dry and never goes away, blurred vision and fair amount of watering eyes. This medication has done great bringing my pressures down from 162/110 down to 106/78. I am sure my body likes these numbers but I cannot tolerate feeling so crappy so much of the time.
Patient Q&A Section about tekturna
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Tekturna still on the market?
"The FDA does not recommend that people with diabetes who are taking angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) take Tekturna."
Answered by AI
What is Tekturna prescribed for?
"It is manufactured by the Swiss pharmaceutical company, Novartis.
Tekturna is a medication that lowers blood pressure, used to treat hypertension. It is manufactured by the Swiss pharmaceutical company, Novartis."
Answered by AI
Is Tekturna and ACE inhibitor?
"A product called aliskiren (Tekturna, Rasilez, Novartis) does not have the same effect as an ACE-inhibitor. An ACE-inhibitor prevents the breakdown of bradykinin. Increased levels of bradykinin cause the release of local vasodilators and may be part of the additional protective benefit of ACE-inhibitors."
Answered by AI
What type of drug is Tekturna?
"Tekturna is the first FDA-approved drug in a new class of high blood pressure drugs that work by inhibiting the production of renin, an enzyme produced by the kidneys. Renin helps to regulate blood pressure and its overproduction can lead to higher blood pressure."
Answered by AI