Tekturna

Hypertensive disease, not adequately controlled with monotherapy

Treatment

2 FDA approvals

20 Active Studies for Tekturna

What is Tekturna

Aliskiren

The Generic name of this drug

Treatment Summary

Aliskiren is a medication used to treat high blood pressure. It was developed by Speedel and Novartis and approved by the FDA in 2007. Aliskiren works by blocking an enzyme known as renin and can be used on its own or in combination with other medications to reduce blood pressure.

Tekturna

is the brand name

image of different drug pills on a surface

Tekturna Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Tekturna

Aliskiren

2007

36

Approved as Treatment by the FDA

Aliskiren, also known as Tekturna, is approved by the FDA for 2 uses including Hypertensive disease and not adequately controlled with monotherapy .

Hypertensive disease

Used to treat High Blood Pressure (Hypertension) in combination with Amlodipine

not adequately controlled with monotherapy

Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide

Effectiveness

How Tekturna Affects Patients

Aliskiren lowers blood pressure by blocking the enzyme renin. This has a chain reaction that results in lower blood pressure, which can help prevent life-threatening and non-deadly cardiovascular issues such as stroke and heart attack.

How Tekturna works in the body

Aliskiren is a drug that helps lower blood pressure by blocking the action of a protein called renin. Normally, when blood volume and renal perfusion decrease, renin is released from the kidneys. Renin then turns a protein called angiotensinogen into angiotensin I, which is then converted to angiotensin II. Angiotensin II is a hormone that causes blood vessels to constrict, which increases blood pressure. Aliskiren works by binding to renin and preventing it from turning angiotensinogen into angiotensin I, thereby stopping the release of angiotensin II

When to interrupt dosage

The amount of Tekturna is subject to the diagnosed state. The dosage amount shifts as per the system of delivery (e.g. Oral or Tablet, film coated) provided in the table beneath.

Condition

Dosage

Administration

not adequately controlled with monotherapy

300.0 mg, 150.0 mg,

Tablet, film coated - Oral, , Oral, Tablet, film coated, Tablet - Oral, Tablet

Hypertensive disease

300.0 mg, 150.0 mg,

Tablet, film coated - Oral, , Oral, Tablet, film coated, Tablet - Oral, Tablet

Warnings

Tekturna has four counterindications and should not be ingested when confronting any of the conditions given in the following table.

Tekturna Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Type 2 Diabetes

Do Not Combine

Type 2 Diabetes

Do Not Combine

There are 20 known major drug interactions with Tekturna.

Common Tekturna Drug Interactions

Drug Name

Risk Level

Description

Amifostine

Major

Aliskiren may increase the hypotensive activities of Amifostine.

Azilsartan medoxomil

Major

Aliskiren may increase the hypotensive and hyperkalemic activities of Azilsartan medoxomil.

Benazepril

Major

The risk or severity of hypotension, hyperkalemia, and nephrotoxicity can be increased when Aliskiren is combined with Benazepril.

Benazeprilat

Major

The risk or severity of hypotension, hyperkalemia, and nephrotoxicity can be increased when Aliskiren is combined with Benazeprilat.

Captopril

Major

The risk or severity of hypotension, hyperkalemia, and nephrotoxicity can be increased when Aliskiren is combined with Captopril.

Tekturna Toxicity & Overdose Risk

The lowest toxic dose of aliskiren in rats has been found to be greater than 2000mg/kg. If someone takes too much aliskiren, they may experience low blood pressure, and should receive supportive treatment.

image of a doctor in a lab doing drug, clinical research

Tekturna Novel Uses: Which Conditions Have a Clinical Trial Featuring Tekturna?

18 active studies are currently investigating the potential of Tekturna in ameliorating Hypertensive diseases.

Condition

Clinical Trials

Trial Phases

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

not adequately controlled with monotherapy

0 Actively Recruiting

Tekturna Reviews: What are patients saying about Tekturna?

5

Patient Review

8/13/2015

Tekturna for High Blood Pressure

I've been on Tekturna for four years now and it's helped me immensely with my high blood pressure and protein loss due to kidney disease. I've tried many other medications, but this one is by far the most effective. The downside is that I'm always tired and have lost some hair, but all medications come with side effects.

5

Patient Review

8/30/2012

Tekturna for High Blood Pressure

I've been on this medication for a few years now with no issues. I just recently started having some problems with blood sugar, but I'm not sure if it's related to the Tekturna or not. The other drugs prescribed for high blood pressure always made me exhausted and I would constantly wake up during the night, but Tekturna has helped me sleep better.

5

Patient Review

9/25/2011

Tekturna for High Blood Pressure

5

Patient Review

6/5/2013

Tekturna for High Blood Pressure

Tekturna has been a life-saver for me. For the last five years, it's kept my blood pressure in check with no known side effects. It is expensive, but to me, it's worth every penny because I don't have to deal with fatigue like I did with other medications.

4.3

Patient Review

4/14/2015

Tekturna for High Blood Pressure

I've been using Tekturna for eight years now and it's kept my blood pressure in check with few side effects. I'm glad the price has gone down recently, as it was getting pretty expensive.

4

Patient Review

12/7/2011

Tekturna for High Blood Pressure

I've only been on this medication for a week, but my doctor prescribed it to me in order to lower my protein level due to kidney failure. So far, I haven't noticed any significant changes.

3.7

Patient Review

2/12/2012

Tekturna for High Blood Pressure

Cardiologist took me off Tekturna due to severe hoarseness, heartburn, and flu-like symptoms. My Cardiologist told me that this drug was being taken off the market.

3.7

Patient Review

12/14/2011

Tekturna for High Blood Pressure

I was dealing with some serious swelling in my ankles that was radiating upwards and causing muscle spasms.

3.3

Patient Review

3/15/2012

Tekturna for High Blood Pressure

I experienced severe acid reflux, stomach cramps & painful gas, a salty taste in my mouth, confusion & dizziness when moving. My muscles cramped up so badly I couldn't lift anything more than a piece of paper. The cramps would last till the next morning, at which time I'd take another pill. But no more for me. So glad my doctor recognized these symptons and that I'm on the road to recovery.

3

Patient Review

1/28/2012

Tekturna for High Blood Pressure

So far, this medication has not lowered my blood pressure.

2.7

Patient Review

1/19/2012

Tekturna for High Blood Pressure

I had a really bad reaction to Tekturna. My blood pressure spiked incredibly high and I developed terrible headaches, dizziness, and fatigue. Definitely not worth it.

2.7

Patient Review

7/9/2012

Tekturna for High Blood Pressure

I started losing large amounts of hair and it's really worrying me. My doctor doesn't know about this side effect, but it's getting worse.

2.3

Patient Review

12/27/2011

Tekturna for High Blood Pressure

While this drug has been helpful in controlling my blood pressure, it has unfortunately also caused erectile dysfunction. This is apparently a very common side effect of the medication, so I have decided to stop taking it.

2.3

Patient Review

9/25/2011

Tekturna for High Blood Pressure

2.3

Patient Review

12/17/2011

Tekturna for High Blood Pressure

While this medicine has helped me in some ways, I have found that it zaps my energy levels.

1.3

Patient Review

1/13/2012

Tekturna for High Blood Pressure

I found myself with a sore throat, tired more so than usual, cough that is dry and never goes away, blurred vision and fair amount of watering eyes. This medication has done great bringing my pressures down from 162/110 down to 106/78. I am sure my body likes these numbers but I cannot tolerate feeling so crappy so much of the time.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tekturna

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Tekturna still on the market?

"The FDA does not recommend that people with diabetes who are taking angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) take Tekturna."

Answered by AI

What is Tekturna prescribed for?

"It is manufactured by the Swiss pharmaceutical company, Novartis.

Tekturna is a medication that lowers blood pressure, used to treat hypertension. It is manufactured by the Swiss pharmaceutical company, Novartis."

Answered by AI

Is Tekturna and ACE inhibitor?

"A product called aliskiren (Tekturna, Rasilez, Novartis) does not have the same effect as an ACE-inhibitor. An ACE-inhibitor prevents the breakdown of bradykinin. Increased levels of bradykinin cause the release of local vasodilators and may be part of the additional protective benefit of ACE-inhibitors."

Answered by AI

What type of drug is Tekturna?

"Tekturna is the first FDA-approved drug in a new class of high blood pressure drugs that work by inhibiting the production of renin, an enzyme produced by the kidneys. Renin helps to regulate blood pressure and its overproduction can lead to higher blood pressure."

Answered by AI

Clinical Trials for Tekturna

Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

Have you considered Tekturna clinical trials?

We made a collection of clinical trials featuring Tekturna, we think they might fit your search criteria.
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Text Message Reminders for High Blood Pressure

18+
All Sexes
Detroit, MI

This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early PreVEntion in the GREAT LakEs Region) Center (IRB# 100221MP2A), the purpose of which is to improve cardiometabolic health in two uniquely comparable cities: Detroit, Michigan, and Cleveland, Ohio. The ACHIEVE GREATER Center involves separate but related projects that aim to improve cardiometabolic health outcomes through better risk factor control for three chronic conditions that are of tremendous public health importance, (hypertension (HTN), heart failure, and coronary heart disease), all of which contribute significantly to premature death in Detroit and Cleveland. The present study is the prospective observational cohort component of ACHIEVE P1- EPI (Project 1) of the ACHIEVE GREATER Center and serves to characterize the population of patients with blood pressure (BP) levels above normal attending The Wayne Health Mobile Health Unit (MHU) events to better understand key factors (e.g., social determinants of health) that convey information about baseline BP levels and related clinical outcomes (e.g., follow-up clinic visits, BP control, and cardiovascular events).

Recruiting
Has No Placebo

Wayne Health Mobile Units

Steven J Korzeniewski, PhD

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We made a collection of clinical trials featuring Tekturna, we think they might fit your search criteria.
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Image of Northern Arizona University in Flagstaff, United States.

CardioCare Quest for High Blood Pressure

18+
All Sexes
Flagstaff, AZ

This project aims to address healthcare disparities among Navaho people diagnosed with hypertension or prehypertension through three main objectives. Firstly, it identifies and shares insights on healthcare access disparities affecting Navaho individuals experiencing nonadherence to hypertension treatment. Secondly, the proposal develops a telehealth solution based on factors identified as knowledge gaps caused by healthcare access disparities in hypertension management; we will use the factors to design a series of engaging minigames that can be incorporated into the larger CardioCare Quest. These minigames will be co-designed with end users and clinicians. Finally, the proposal conducts comprehensive qualitative and quantitative assessments of user experiences, perceptions, and challenges with CardioCare Quest.

Recruiting
Has No Placebo

Northern Arizona University (+1 Sites)

Tochukwu Ikwunne, PhD

Image of Tufts University in Boston, United States.

Food as Medicine for Cardiometabolic Health

18+
All Sexes
Boston, MA

Though the Mississippi Delta has a rich agricultural history and some of the nation's most fertile soil, residents have experienced the legacy of slavery and economic exploitation through food insecurity and poverty for generations. This project focuses on Bolivar, Washington, and Sunflower, contiguous counties in the Delta that are designated as health disparity populations. Over 65% of the 100,000 residents are Black/African American and \~30% live at or below the poverty level. Obesity rates are high and the rate of diabetes is almost double the national average. Tufts University received a grant from the National Institute of Minority Health and Health Disparities to develop, test, and evaluate a Food is Medicine program in Mississippi. The Delta Growing a Resilient, Enriching, Equitable, Nourishing food System (GREENS) Food is Medicine (FIM) Project, is a collaborative project in Bolivar, Washington, and Sunflower counties in Mississippi. The intervention involves regularly distributed fruit and vegetable produce boxes as well as nutrition education materials to the intervention group. The control group will receive produce boxes later, after they complete study activities. The project's primary goal is to improve health outcomes by creating a FIM intervention. The Delta GREENS FIM Project aims to become a model for promoting nutrition security and management of chronic conditions in varied communities nationwide.

Recruiting
Has No Placebo

Tufts University

Christina D Economos, PhD

Have you considered Tekturna clinical trials?

We made a collection of clinical trials featuring Tekturna, we think they might fit your search criteria.
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