Sinequan

Insomnia, Neurotic depression, Depression + 8 more
Treatment
20 Active Studies for Sinequan

What is Sinequan

DoxepinThe Generic name of this drug
Treatment SummaryDoxepin is a drug prescribed to treat depression, anxiety, and insomnia. It is a type of medication known as a tertiary amine that helps to balance the levels of certain chemicals in the brain. Doxepin was first approved by the FDA in 1969 for the treatment of depression and later approved for the treatment of insomnia in 2010. It belongs to the same drug family as amitriptyline, clomipramine, desipramine, imipramine, nortriptyline, protriptyline, and trimipramine.
Sinequanis the brand name
image of different drug pills on a surface
Sinequan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sinequan
Doxepin
1969
307

Effectiveness

How Sinequan Affects PatientsDoxepin is a type of antidepressant that works by decreasing the activity of the brain. It can also help with insomnia and anxiety. It may take two weeks for the antidepressant effects to show, but the sedative effects are immediate. At high doses, it can cause central nervous system depression and its anticholinergic and antiadrenergic effects can limit its efficacy.
How Sinequan works in the bodyDoxepin works by blocking histamine receptors in the skin to reduce inflammation. It also works on the central nervous system to increase levels of serotonin and norepinephrine. This helps improve mood and reduce depression symptoms. Doxepin may also desensitize serotonin 1A receptors and beta-adrenergic receptors. It is believed to increase dopamine transmission in the frontal cortex which is thought to help improve mood.

When to interrupt dosage

The advocated dose of Sinequan is contingent upon the determined condition, for example Depression, Involutional, Mental Disorder, Organic and Insomnia. The dose can be found in the table below, based on the technique of delivery (e.g. Oral or Tablet - Oral).
Condition
Dosage
Administration
Neurotic depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Insomnia
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neuropathic Pain
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Behcet Syndrome
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
psychotic depressive disorder
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Itching
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Generalized Anxiety Disorder
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Lichen simplex chronicus
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depression, Involutional
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Alcoholism
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated

Warnings

Sinequan has four contraindications and thus should not be taken when encountering any of the conditions shown in the following table.Sinequan Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Doxepin may interact with Pulse Frequency
untreated narrow angle glaucoma
Do Not Combine
Pulse Frequency
Do Not Combine
Urinary Retention
Do Not Combine
There are 20 known major drug interactions with Sinequan.
Common Sinequan Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
Doxepin may increase the vasopressor activities of 4-Methoxyamphetamine.
Acepromazine
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Doxepin is combined with Aclidinium.
Alfuzosin
Major
Doxepin may increase the hypotensive activities of Alfuzosin.
Aripiprazole
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Sinequan Toxicity & Overdose RiskDoxepin is toxic in high doses, with a lethal dose of 180mg/kg in mice and 147mg/kg in rats. Overdosing on doxepin can cause seizures, heart rhythm problems, loss of consciousness, low blood pressure, central nervous system depression, changes on an EKG, and even death. In fertility studies, doxepin was found to reduce the time of copulation, decrease the number of viable embryos, decrease litter size, and decrease sperm motility. There is no evidence that doxepin causes cancer or mutations.
image of a doctor in a lab doing drug, clinical research

Sinequan Novel Uses: Which Conditions Have a Clinical Trial Featuring Sinequan?

1020 active trials are being conducted to assess the potential of Sinequan in managing Generalized Anxiety Disorder, Atopic Dermatitis and Bipolar Disorder.
Condition
Clinical Trials
Trial Phases
Insomnia
90 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Early Phase 1
Generalized Anxiety Disorder
244 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4
Itching
11 Actively Recruiting
Phase 2, Phase 4, Phase 3, Phase 1
Neurotic depression
0 Actively Recruiting
Depression, Involutional
0 Actively Recruiting
Behcet Syndrome
2 Actively Recruiting
Not Applicable
Alcoholism
8 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Lichen simplex chronicus
0 Actively Recruiting
Depression
693 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
psychotic depressive disorder
0 Actively Recruiting
Neuropathic Pain
26 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4

Sinequan Reviews: What are patients saying about Sinequan?

5Patient Review
8/30/2010
Sinequan for Itching
This medication has been a lifesaver for me on two different occasions when I've suffered from chronic urticaria. It's completely alleviated my problem when taken with other OTC antihistamines. I only need to take 10 mg each night for 3-4 weeks during flare-ups now. The main side effects I've experienced are dry mouth and an extreme drop in libido due to decreased lubrication.
5Patient Review
1/17/2018
Sinequan for Nerve Pain
My neurologist prescribed this for me 15 years ago when I was 50 and suffering from peripheral neuropathy pain. It's been a godsend, allowing me to walk without pain.
4.7Patient Review
7/29/2016
Sinequan for Anxiousness associated with Depression
Doxepin has been a game-changer for me. It's helped with my anxiety, depression, and insomnia. I have experienced dry mouth as a side effect; however, it hasn't been bad enough to make me want to stop taking the medication.
4.3Patient Review
5/1/2010
Sinequan for Anxiousness associated with Depression
Sinequan has been an utter game-changer for me. I was struggling with anxiety and depression to the point where I rarely left my house, but this medication helped me get my life back. The only downside is that I've gained about 30 pounds since starting it.
3.7Patient Review
10/8/2011
Sinequan for Anxious
This medication didn't do much for my constipation.
3Patient Review
11/2/2011
Sinequan for Depression
I started taking this treatment two weeks ago. So far, I haven't seen a huge difference, but it takes time for medications to build up in your system so I'm hopeful.
2.3Patient Review
9/24/2013
Sinequan for Depression
I'm still struggling with depression, and this medication hasn't been helping.
1.7Patient Review
3/16/2014
Sinequan for Depression
This didn't help me at all and I had a lot of trouble sleeping.
1Patient Review
3/26/2010
Sinequan for Bipolar Depression
The side effects of this medication were really terrible. I gained a lot of weight, felt groggy and irritable the next day, and would wake up in the middle of the night and eat everything in sight. I stopped taking it after only 8 months because it was making me so unhealthy.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sinequan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How much sinequan can you take for sleep?

"Adults should take 6 milligrams (mg) of the medication once a day. Older adults should take 3 mg of the medication once a day. The doctor may adjust the dose as needed."

Answered by AI

Is sinequan still prescribed?

"The brand name Sinequan is no longer available in the United States. However, generic forms are still available."

Answered by AI

What is the drug sinequan used for?

"This medication is used to improve mood, relieve tension and anxiety, help with sleep, and increase energy. It belongs to a class of medications called tricyclic antidepressants."

Answered by AI

Is doxepin a good sleeping pill?

"This results in improvement in depression or anxiety.

Doxepin is used to treat anxiety or depression and also to treating insomnia by increasing levels of certain chemicals in the brain, which improves depression or anxiety."

Answered by AI

Clinical Trials for Sinequan

Have you considered Sinequan clinical trials? We made a collection of clinical trials featuring Sinequan, we think they might fit your search criteria.
Have you considered Sinequan clinical trials? We made a collection of clinical trials featuring Sinequan, we think they might fit your search criteria.
Have you considered Sinequan clinical trials? We made a collection of clinical trials featuring Sinequan, we think they might fit your search criteria.