This trial is evaluating whether Furosemide will improve 1 primary outcome in patients with Acute Kidney Injury. Measurement will happen over the course of 14 days or discharge.
This trial requires 200 total participants across 1 different treatment group
This trial involves a single treatment. Furosemide is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"The only trial involving furosemide used in patients with AKI is a retrospective review using furosemide in patients with AKI. Further prospective studies are needed to confirm the role of furosemide in AKI." - Anonymous Online Contributor
"This article discusses the most commonly used classification criteria in AKI. The classification criteria are based on underlying pathobiology and can provide useful information about treatment response, prognosis and outcomes. In acute kidney injury, acute tubular necrosis predominates at diagnosis in the vast majority of patients, and this is the focus of treatment. Acute tubular necrosis may have a more aggressive course than acute renal vasculitis or acute tubular apoptosis, and the former two may require less aggressive treatment in refractory acute kidney injury." - Anonymous Online Contributor
"The signs of AKI generally occur early in the course of disease. Most of these signs are nonspecific, but there are other signs that may be useful in the diagnosis of AKI. The use of serum creatinine as a diagnostic test alone is inadequate for detecting AKI." - Anonymous Online Contributor
"Medications are the most common treatment for acute kidney injury. Medications are frequently given while dialyzing patients. For patients with acute kidney-injury not induced by hemodialysis, maintenance of blood pressure, blood volume control, blood potassium and proper oxygenation of the blood are the most essential treatment." - Anonymous Online Contributor
"The incidence of AKI in critically ill patients was high and varied by different hospital settings. Incidence of renal failure, acute kidney injury, and subsequent chronic kidney disease occurred in most critically ill patients. Future research is needed to identify more effective AKI prevention strategies in critically ill patients." - Anonymous Online Contributor
"Patients with AKI and their care team must pay attention to signs of fluid overload: raised jugular venous pressure, elevated central venous pressure, and increased total body weight. Patients should have their fluid status carefully monitored. A simplified acute renal injury (S-AKI) scoring system can be an important tool in identifying patients at risk of developing a significant decrease in kidney function." - Anonymous Online Contributor
"Acute kidney injury has a very poor outcome unless treated, and a major determinant of mortality in many patients with AKI. Treatment with ACE inhibitors reduces progression to chronic kidney disease and is associated with a higher incidence of renal recovery in patients." - Anonymous Online Contributor
"The current formulation of furosemide appears to be the safest and most effective option for prevention of acute kidney injury in high-risk critically ill patients. For short-term use, furosemide has the most evidence supporting its safety and efficacy in the critically ill patient. The combination of furosemide and thiazide is also a common option for prevention of acute kidney injury in critically ill patients; however, furosemide is a more effective agent, less nephrotoxic, and more suitable for those with renal impairment." - Anonymous Online Contributor
"In patients with acute kidney injury--even those with severe acute kidney injury--who were receiving guideline-based care, furosemide therapy was associated with improved 1-month survival and reduced length of stay, as well as improved functional outcomes. Findings from a recent study supports the use of furosemide to reverse acute kidney injury and improve quality of life." - Anonymous Online Contributor
"AKI is a potentially life-threatening adverse event after liver transplantation and must not be ignored. The main strategies for early prediction of posttransplant nephrotoxicity are: the recipient's general health status, serum alkaline phosphatase level, and creatinine levels prior to and during the OLT. To limit unnecessary AKI, serum creatinine levels should be monitored constantly." - Anonymous Online Contributor
"[More than 2,500 cases of acute kidney injury occurred in acute pediatric wards of 4 hospitals in Sweden in 2013 (reference: SFR 2014/542). The latest research on acute kidney injury has led to improvements in detection and treatment, with a reduction in the number of hospital in-patient deaths and the length of a hospital stay. The findings of meta-analyses published in high-impact medical journals of randomized controlled studies have led to further improvements in the care of pediatric acute kidney injury.] The latest research on acute kidney injury, summarized in the article, aims at developing treatment and management strategies through randomized controlled trials to improve results. This has already been done in different areas with limited or even contradictory results." - Anonymous Online Contributor
"Intravenous administration of furosemide does not alter the serum phosphate levels, therefore, it is recommended that these patients are carefully monitored for serum phosphate changes and phosphate depletion due to excessive diuresis." - Anonymous Online Contributor