Furosemide for Acute Kidney Failure
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how well certain blood and urine markers can predict the course of Acute Kidney Injury (AKI), a condition where the kidneys suddenly fail to filter waste from the blood. Researchers are testing whether these markers can foresee outcomes like the need for dialysis or recovery. The trial involves the drug furosemide, known as Lasix, which often helps remove excess fluid from the body. Suitable participants include those with a recent increase in kidney-related blood markers or reduced urine output, who also have a bladder catheter in place. As an unphased study, this trial offers a unique opportunity to contribute to understanding AKI and its treatment.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatment is likely to be safe?
Research shows that furosemide, the treatment under study, is generally well-tolerated and often treats fluid buildup from conditions like heart failure and kidney disease. Most people's bodies handle it well. However, like all medicines, it can cause side effects. The most common are dehydration and low blood pressure. Furosemide has been used for a long time and is FDA-approved for other conditions, indicating its safety when used correctly. Always consult a doctor with any concerns.12345
Why are researchers excited about this trial?
Most treatments for acute kidney injury (AKI) focus on managing symptoms and supporting kidney function while the body heals. However, furosemide, commonly known as Lasix, is different because it is a loop diuretic that helps remove excess fluid from the body. Researchers are excited about this treatment because it may not only relieve the symptoms of AKI but also potentially improve outcomes by directly targeting fluid overload, which can be a critical factor in the severity of AKI. This approach could lead to faster recovery times and better overall kidney function compared to traditional methods that primarily focus on symptom management.
What evidence suggests that Furosemide might be an effective treatment for Acute Kidney Injury?
Research has shown that furosemide, also known as Lasix, effectively treats conditions with excess fluid in the body, such as heart failure. Studies have found that high doses of furosemide can lead to significant fluid and weight loss, easing symptoms like shortness of breath. In a clinical trial, researchers compared furosemide to another diuretic, and both showed similar patient survival rates, indicating its effectiveness. Although furosemide is not specifically approved for sudden kidney problems (acute kidney injury or AKI), it can increase urine output, potentially helping to manage some AKI symptoms by reducing extra fluid. This trial will specifically explore the effects of furosemide on outcomes in AKI, with participants receiving doses based on their previous exposure to diuretics.36789
Who Is on the Research Team?
Jay L Koyner, MD
Principal Investigator
University of Chicago
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive furosemide to assess its effect on the severity and outcome of Acute Kidney Injury
Follow-up
Participants are monitored for safety and effectiveness after treatment, including long-term outcomes 2-3 years post-AKI
What Are the Treatments Tested in This Trial?
Interventions
- Furosemide
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor