The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury
Recruiting at 3 trial locations
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Chicago
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 5 JurisdictionsThis treatment is already approved in other countries
Trial Summary
What is the purpose of this trial?
This trial aims to use blood and urine tests to find indicators that can predict how severe Acute Kidney Injury (AKI) will become. It focuses on critically ill patients with AKI to help doctors foresee the need for dialysis or recovery chances.
Research Team
JL
Jay L Koyner, MD
Principal Investigator
University of Chicago
Eligibility Criteria
Inclusion Criteria
18 yrs or older
increase in serum creatinine of 0.3 mg/dl within 48 hours or an increase of greater than or equal to 150% from baseline or sustained oliguria (UOP < 0.5 cc/kg/hr for 6 hours with the last 48hours)
written informed consent
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Timeline
Screening
Participants are screened for eligibility to participate in the trial
1-2 weeks
Treatment
Participants receive furosemide to assess its effect on the severity and outcome of Acute Kidney Injury
7 days
Daily monitoring during hospital stay
Follow-up
Participants are monitored for safety and effectiveness after treatment, including long-term outcomes 2-3 years post-AKI
3 years
Treatment Details
Interventions
- Furosemide
Participant Groups
1Treatment groups
Experimental Treatment
Group I: LasixExperimental Treatment1 Intervention
Pt to get dose of furosemide after meeting entry criteria - dose dependent on previous exposure to diuretics
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Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor
Trials
1,086
Recruited
844,000+
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