Deep TMS for Alcoholism
Trial Summary
Will I have to stop taking my current medications?
You can continue taking medications for depression, smoking, or other psychiatric conditions as long as they don't lower the seizure threshold. The trial does not require stopping these medications, but you must be abstinent from alcohol and non-prescribed substances for at least 7 days before starting the treatment.
What data supports the effectiveness of the treatment Deep Transcranial Magnetic Stimulation (dTMS) for alcoholism?
Research suggests that Deep Transcranial Magnetic Stimulation (dTMS) may help reduce alcohol intake and cravings in people with alcohol use disorder. Studies have shown that dTMS can affect brain areas related to addiction, potentially leading to decreased alcohol consumption and changes in brain chemicals linked to addiction.12345
Is Deep TMS safe for humans?
How is the Deep TMS treatment different from other treatments for alcoholism?
Deep TMS (Transcranial Magnetic Stimulation) using the H7 coil is unique because it targets deeper brain regions like the medial prefrontal cortex, which are involved in addiction pathways. This treatment modulates dopamine and cortisol levels, potentially reducing alcohol cravings and intake, unlike traditional therapies that may not directly influence these brain areas.12458
What is the purpose of this trial?
This study aims to evaluate the efficacy of deep transcranial magnetic stimulation (dTMS) as a treatment for Veterans with an alcohol use disorder (AUD).
Research Team
Timothy Durazzo, PhD
Principal Investigator
Stanford University
Claudia Padula, PhD
Principal Investigator
Stanford University
Michelle Madore, PhD
Principal Investigator
Stanford University
Eligibility Criteria
This trial is for Veterans aged 21-70 with alcohol use disorder (AUD) who are in active treatment, can consent in English, and have been sober for at least 7 days. It's not for those with severe heart or lung conditions, metal implants incompatible with magnetic fields, certain psychiatric disorders like schizophrenia or bipolar disorder, pregnant women, or anyone on medications that lower seizure threshold.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 30 dTMS treatments, administered 3 times per day over 10 consecutive business days
Follow-up
Participants are monitored for safety and effectiveness after treatment, with a focus on relapse prevention
Treatment Details
Interventions
- Deep Transcranial Magnetic Stimulation (dTMS) H7 coil
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor
VA Palo Alto Health Care System
Collaborator