Sevelamer Hydrochloride

Hyperphosphataemia, Hemodialysis
Treatment
2 FDA approvals
11 Active Studies for Sevelamer Hydrochloride

What is Sevelamer Hydrochloride

SevelamerThe Generic name of this drug
Treatment SummarySevelamer, sold under the brand name Renagel, is a medication used to prevent high levels of phosphorus in people with chronic kidney disease. It works by binding to phosphorus in the intestines and blocking its absorption into the blood.
Renagelis the brand name
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Sevelamer Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Renagel
Sevelamer
2006
81

Approved as Treatment by the FDA

Sevelamer, otherwise called Renagel, is approved by the FDA for 2 uses including Hyperphosphataemia and Hemodialysis .
Hyperphosphataemia
Helps manage Hyperphosphataemia
Hemodialysis
Helps manage Hemodialysis Treatment

Effectiveness

How Sevelamer Hydrochloride Affects PatientsPeople with end-stage renal disease often have too much phosphorus in their blood (called hyperphosphatemia). This can cause a build-up of calcium which can lead to damage. Hyperphosphatemia can also cause an increase in a hormone called parathyroid hormone (PTH) which can cause bone disease. To treat hyperphosphatemia, people reduce the amount of phosphorus they eat, take medicines to prevent their body from absorbing phosphorus, or use dialysis to remove it from their body. Sevelamer is a medicine that can be taken with meals to decrease the amount of phosphorus in the body and also lower
How Sevelamer Hydrochloride works in the bodySevelamer stops too much phosphate from entering your body by binding to it in the digestive tract. This reduces the amount of phosphate in your blood and lowers your parathyroid hormone levels.

When to interrupt dosage

The recommended dosage of Sevelamer Hydrochloride is contingent upon the determined illness. The amount of dosage deviates, contingent upon the technique of delivery (e.g. Parenteral or Capsule) as noted in the table below.
Condition
Dosage
Administration
Hemodialysis
800.0 mg, , 400.0 mg, 403.0 mg, 1600.0 mg, 2400.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Powder, for suspension, Powder, for suspension - Oral, Tablet, film coated - Parenteral, Parenteral
Hyperphosphataemia
800.0 mg, , 400.0 mg, 403.0 mg, 1600.0 mg, 2400.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Powder, for suspension, Powder, for suspension - Oral, Tablet, film coated - Parenteral, Parenteral

Warnings

There are 20 known major drug interactions with Sevelamer Hydrochloride.
Common Sevelamer Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Mycophenolic acid
Major
The serum concentration of Mycophenolic acid can be decreased when it is combined with Sevelamer.
Raloxifene
Major
Sevelamer can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m oxidronate
Major
Sevelamer may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
(R)-warfarin
Minor
Sevelamer can cause a decrease in the absorption of (R)-warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
(S)-Warfarin
Minor
Sevelamer can cause a decrease in the absorption of (S)-Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Hydrochloride Toxicity & Overdose RiskSevelamer has been tested on healthy volunteers up to 14 grams per day over eight days without any side effects. It has also been tested on hemodialysis patients up to 13 grams per day with no reported overdoses. Since sevelamer is not absorbed into the body, it has a low risk of causing toxicity.
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Sevelamer Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Sevelamer Hydrochloride?

Condition
Clinical Trials
Trial Phases
Hyperphosphataemia
0 Actively Recruiting
Hemodialysis
11 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1

Sevelamer Hydrochloride Reviews: What are patients saying about Sevelamer Hydrochloride?

5Patient Review
7/15/2009
Sevelamer Hydrochloride for High Amount of Phosphate in the Blood
This treatment seems to be effective.
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Patient Q&A Section about sevelamer hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the action of sevelamer?

"The drug sevelamer works by binding to phosphate in food as it's being digested, so that the body absorbs less phosphate. This helps to lower blood levels of parathyroid hormone."

Answered by AI

Why do renal patients take sevelamer?

"Sevelamer is an effective medication for decreasing phosphorus and calcium-phosphate levels in the blood, as well as lipid levels, without also raising serum calcium levels. This is true for Chinese dialysis patients whether sevelamer is used as a monotherapy or in combination with other treatments."

Answered by AI

What is sevelamer hydrochloride used for?

"Sevelamer is a prescription medication used to treat hyperphosphatemia (too much phosphate in the blood) in patients with chronic kidney disease who are on dialysis."

Answered by AI

What drug class is sevelamer hydrochloride?

"Sevelamer is a type of medication known as a phosphate binder. It binds to phosphorus from food in your diet and prevents it from being absorbed into your bloodstream."

Answered by AI

Clinical Trials for Sevelamer Hydrochloride

Have you considered Sevelamer Hydrochloride clinical trials? We made a collection of clinical trials featuring Sevelamer Hydrochloride, we think they might fit your search criteria.
Have you considered Sevelamer Hydrochloride clinical trials? We made a collection of clinical trials featuring Sevelamer Hydrochloride, we think they might fit your search criteria.