← Back to Search

Cure Therapies for HIV

N/A

Recruiting

Led By Francesca Cossarini, MD

Research Sponsored by Icahn School of Medicine at Mount Sinai

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up end of the study (at month one) compared to baseline

Awards & highlights

Study Summary

This trial will test if HIV cure therapies can reduce virus levels in the gut and change the immune system there.

Who is the study for?

This trial is for adults aged 18-75 with chronic HIV infection who are willing to follow the study procedures. They must be able to undergo a colonoscopy twice and be on a treatment that might cure HIV. People with bowel diseases, other gastrointestinal conditions, coagulation problems, or those pregnant or planning pregnancy can't participate.Check my eligibility

What is being tested?

The study aims to see if therapies thought to potentially cure HIV can change immune cells in the gut and lower tissue-associated HIV levels. Participants will have their gastrointestinal tract examined through a colonoscopy before and after receiving these potential cure therapies.See study design

What are the potential side effects?

While not directly related to medication side effects, undergoing a colonoscopy may cause discomfort, bloating, cramps or rarely more serious complications like bleeding or perforation of the colon.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ end of the study (at month one) compared to baseline

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~end of the study (at month one) compared to baseline

This trial's timeline: 3 weeks for screening, Varies for treatment, and end of the study (at month one) compared to baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in HIV tissue viral load

Secondary outcome measures

Change in number of Cytotoxic T cells

Change in number of NK Cells

Trial Design

1Treatment groups

Experimental Treatment

Group I: Patients with HIV TherapyExperimental Treatment1 Intervention

Subjects receiving therapies with the potential for HIV cure

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Colonoscopy

2012

Completed Phase 3

~115560

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Icahn School of Medicine at Mount SinaiLead Sponsor

861 Previous Clinical Trials

525,268 Total Patients Enrolled

Francesca Cossarini, MDPrincipal InvestigatorIcahn School of Medicine at Mount Sinai

Media Library

Patients with HIV Therapy Clinical Trial Eligibility Overview. Trial Name: NCT05652088 — N/A

HIV/AIDS Research Study Groups: Patients with HIV Therapy

HIV/AIDS Clinical Trial 2023: Patients with HIV Therapy Highlights & Side Effects. Trial Name: NCT05652088 — N/A

Patients with HIV Therapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT05652088 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research study permit enrollment of those aged 75 and over?

"To qualify for this clinical trial, interested candidates must be between the ages of 18 and 75. For those patients outside that age range, there are 334 studies available to minors and 1015 investigations open to individuals over 65 years old."

Answered by AI

What are the eligibility requirements for participation in this research endeavor?

"Candidates for this research must be HIV positive and within the age range of 18-75. At present, there is an opportunity to join a cohort of 8 individuals that meet these criteria."

Answered by AI

Is there an ongoing recruitment drive for participants in this experiment?

"According to clinicaltrials.gov, this medical study posted on January 1st 2023 is no longer recruiting patients at this time. However, there are over 1300 other trials actively searching for volunteers currently."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection

Francesca Cossarini 2023. "The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05652088.