Treatment for Methamphetamine Addiction

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Methamphetamine Addiction+4 More
Eligibility
21 - 55
All Sexes
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Study Summary

This trial will help researchers understand how people respond to stress in emergency situations, which could help improve care for patients in the future.

Eligible Conditions
  • Methamphetamine Addiction
  • Stress Physiology
  • Substance Use Disorder
  • Stress, Emotional
  • Stress Reaction

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Study Objectives

10 Primary · 0 Secondary · Reporting Duration: Up to 12 hours

Up to 12 hours
Determine the feasibility and acceptability of an ED-relevant stressor task as compared to a standard social stressor task.
Evaluate ethological ratings of non-verbal behaviors thought to indicate assertion using a rating scale (Ethological Coding System for Interviews) commonly employed in the clinical environment for this purpose.
Evaluate the ED-representativeness of an ED-relevant stressor task compared to a standard social stressor task.
Measure agitation scale ratings (Behavioral Activity Rating Scale) in participants who undergo an ED-relevant stress task compared to a standard social stress task.
Measure agitation scale ratings (Positive and Negative Syndrome Scale - Excited Component) in participants who undergo an ED-relevant stress task compared to a standard social stress task.
Measure the stress response (alpha-amylase) in participants who undergo an ED-relevant stress task compared to a standard social stress task.
Measure the stress response (cortisol) in participants who undergo an ED-relevant stress task compared to a standard social stress task.
Measure the stress response (diastolic blood pressure) in participants who undergo an ED-relevant stress task compared to a standard social stress task.
Measure the stress response (heart rate) in participants who undergo an ED-relevant stress task compared to a standard social stress task.
Measure the stress response (systolic blood pressure) in participants who undergo an ED-relevant stress task compared to a standard social stress task.

Trial Safety

Safety Progress

1 of 3

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1
Psilocybin
2
Treatment (mFOLFOX6, pembrolizumab, propranolol)

Trial Design

0 Treatment Group

30 Total Participants · 0 Treatment Group

Primary Treatment: Treatment · No Placebo Group · N/A

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 12 hours

Who is running the clinical trial?

University of ArkansasLead Sponsor
462 Previous Clinical Trials
146,834 Total Patients Enrolled
Michael P Wilson, M.D., Ph.D.Principal InvestigatorUniversity of Arkansas
3 Previous Clinical Trials
518 Total Patients Enrolled

Eligibility Criteria

Age 21 - 55 · All Participants · 7 Total Inclusion Criteria

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