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What is Saxenda
LiraglutideThe Generic name of this drug
Treatment SummaryVictoza is a medication containing liraglutide, a synthetic version of a human protein called glucagon-like peptide-1 (GLP-1). Liraglutide is very similar to GLP-1, with a slight difference in one amino acid. It also has a fatty acid and a glutamic acid attached to it. Victoza was approved by the FDA in 2010 and is used to help control blood sugar levels in people with type 2 diabetes.
Victozais the brand name
Saxenda Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Victoza
Liraglutide
2010
6
Effectiveness
How Saxenda Affects PatientsLiraglutide is a type of medicine designed to help treat type 2 diabetes, and is taken as a single dose daily. It works by attaching a fatty acid molecule to position 26 of the GLP-1 molecule, which allows it to bind to albumin in the bloodstream and subcutaneous tissue, and be released slowly over time. This reduces how quickly liraglutide is broken down and removed from the body. It helps to increase the secretion of insulin in response to glucose and slows down the emptying of the stomach. Additionally, it does not cause an increase in glucagon secretion when blood sugar levels
How Saxenda works in the bodyLiraglutide is a medication that helps control blood sugar levels. It is a synthetic version of a natural hormone called glucagon-like peptide-1. Liraglutide binds to the glucagon-like peptide-1 receptor, which causes the body to release insulin and reduce its release of glucagon. It also slows down digestion, helping to regulate blood sugar levels.
When to interrupt dosage
The recommended measure of Saxenda is contingent upon the diagnosed condition, including Diet, inadequate control on monotherapy and Disease. The measure of dosage changes per the technique of delivery (e.g. Injection, solution - Subcutaneous or Injection) featured in the table underneath.Condition
Dosage
Administration
Diet
, 6.0 mg/mL, 3.6 mg/mL
Subcutaneous, Solution, , Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Injection, Injection - Subcutaneous
at least one weight-related comorbid condition
, 6.0 mg/mL, 3.6 mg/mL
Subcutaneous, Solution, , Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Injection, Injection - Subcutaneous
Physical Activity
, 6.0 mg/mL, 3.6 mg/mL
Subcutaneous, Solution, , Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Injection, Injection - Subcutaneous
Type 2 Diabetes
, 6.0 mg/mL, 3.6 mg/mL
Subcutaneous, Solution, , Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Injection, Injection - Subcutaneous
Cardiovascular Diseases
, 6.0 mg/mL, 3.6 mg/mL
Subcutaneous, Solution, , Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Injection, Injection - Subcutaneous
Chronic Weight Management therapy
, 6.0 mg/mL, 3.6 mg/mL
Subcutaneous, Solution, , Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Injection, Injection - Subcutaneous
weight ≥60kg
, 6.0 mg/mL, 3.6 mg/mL
Subcutaneous, Solution, , Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Injection, Injection - Subcutaneous
Major Adverse Cardiovascular Events
, 6.0 mg/mL, 3.6 mg/mL
Subcutaneous, Solution, , Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Injection, Injection - Subcutaneous
BMI >27 kg/m2
, 6.0 mg/mL, 3.6 mg/mL
Subcutaneous, Solution, , Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Injection, Injection - Subcutaneous
Warnings
Saxenda ContraindicationsCondition
Risk Level
Notes
Multiple Endocrine Neoplasia
Do Not Combine
Patient History of Medullary Thyroid Carcinoma
Do Not Combine
Medullary carcinoma of thyroid
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Liraglutide may interact with Pulse Frequency
Common Saxenda Drug Interactions
Drug Name
Risk Level
Description
2,4-thiazolidinedione
Moderate
The risk or severity of hypoglycemia can be increased when Liraglutide is combined with 2,4-thiazolidinedione.
AICA ribonucleotide
Moderate
The risk or severity of hypoglycemia can be increased when Liraglutide is combined with AICA ribonucleotide.
AMG-222
Moderate
The risk or severity of hypoglycemia can be increased when Liraglutide is combined with AMG-222.
Acetohexamide
Moderate
Liraglutide may increase the hypoglycemic activities of Acetohexamide.
Albiglutide
Moderate
The risk or severity of hypoglycemia can be increased when Liraglutide is combined with Albiglutide.
Saxenda Toxicity & Overdose RiskLiraglutide is safe and effective for people of all races, genders, and ages. However, elderly patients may be more likely to experience side effects. Women are more likely to have reduced clearance of liraglutide, but no dosage adjustment is necessary. The safety and benefits of liraglutide must be weighed before prescribing it to pregnant or breastfeeding women, as there is a risk of birth defects and the drug may be present in breast milk. Liraglutide has not been studied in pediatric or very obese patients or in those with end-stage renal or hepatic disease, so
Saxenda Novel Uses: Which Conditions Have a Clinical Trial Featuring Saxenda?
238 active clinical trials are currently underway to evaluate the potential of Saxenda in the treatment of Diseases, Physical Activity and Diet-related issues.Condition
Clinical Trials
Trial Phases
BMI >27 kg/m2
0 Actively Recruiting
Diet
5 Actively Recruiting
Not Applicable
weight ≥60kg
0 Actively Recruiting
Cardiovascular Diseases
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
Major Adverse Cardiovascular Events
0 Actively Recruiting
at least one weight-related comorbid condition
0 Actively Recruiting
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Saxenda Reviews: What are patients saying about Saxenda?
5Patient Review
11/10/2022 I started using this treatment a week ago and I'm already down 4.6 kg. I'm really surprised at how well it works with almost no side effects. The only issue I have is a dry mouth for a few hours after, but it's worth it since I have no desire to eat whatsoever.
5Patient Review
9/18/2022 I'm on my second week of Saxenda and have lost 7lbs already. I find that by going low and slow with the dosage increases, I don't experience any negative side effects like nausea or wind. Additionally, my reduced appetite and lack of sugar cravings are extremely helpful in maintaining a healthy weight loss.
5Patient Review
11/10/2022 This treatment has been a game-changer for me. I've always struggled with feeling full and satisfied after eating, but since starting this medication, that's no longer an issue. I definitely recommend it if you're looking for something to help control your appetite.
4.7Patient Review
10/20/2022 I was really pleased with how much weight I lost in the first two weeks- 11 pounds! And, it curbed my appetite so that I was making healthier choices without feeling deprived. The only downside is that I sometimes felt nauseous or got headaches, but those have gone away now. Always drink lots of fluids!
4.3Patient Review
10/20/2022 I've only been taking Saxenda for a short time, but I've already lost five pounds! The first few days were tough as my body adjusted to the medication. I experienced a lot of nausea and had to keep burping. Drinking lots of liquids helped a lot, as did changing my diet. Now that I'm more used to the medication, I haven't had any problems with constipation or diarrhea (as long as I keep my meals light).
4.3Patient Review
11/4/2022 I've been on this medication for three weeks and have lost 16 pounds. It's not a quick fix, but with exercise and dieting it can be very effective. The longer you use it, the less effective it becomes though. So far no negative side effects that I've noticed.
3.7Patient Review
9/26/2022 I started this today and am already feeling nauseous and have been burping constantly. I hope the effects will dissipate soon.
3.7Patient Review
10/13/2022 I have been taking this medication for about a month and it has helped me lose weight. However, the side effects are really unpleasant and I don't think they are getting any better.
3.3Patient Review
11/12/2022 I started off on a low dose of Saxenda and found it relatively easy to inject. However, the morning after I increased my dosage to 1.2, I woke up vomiting and had severe diarrhea. This has continued for over eight days now, making it hard for me to leave the house or go to work. I have decreased the dose in hopes that it will help alleviate these symptoms. Not surprisingly, I have lost 2.9 kg in 2 weeks.
3Patient Review
10/26/2022 I've been on this treatment for three weeks now (1.8 dosage) and I have to say that I don't feel great most of the time. I'm constantly nauseous, which suppresses my appetite, and as a result I struggle to eat throughout the day. I didn't start seeing any weight loss until week two, and so far I'm down 5lbs. Not sure if I'll continue with this treatment after my third pen runs out.
3Patient Review
9/27/2022 I had great results with Saxenda for the first few months, losing around 30 pounds. However, once I stopped seeing results and my bad eating habits returned, I quickly gained back 10 pounds. Has anyone else experienced this?
1.7Patient Review
11/10/2022 I would not recommend this medication to anyone. It made me feel awful every single day, and I couldn't even do my job properly. I was sick a few times, even with taking anti acids and doing everything that was recommended for the side effects.
1.3Patient Review
10/8/2022 I experienced extreme fatigue, weakness, nausea, and vomiting. This drug also caused gall bladder disease and necessitated the removal of my gall bladder. I lost 20 lbs in 4 months but was so sick from the drug I stopped taking it. After stopping, my metabolism was even slower than before. Now I am struggling with pancreas problems.
Patient Q&A Section about saxenda
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Saxenda work immediately?
"This means that it mimics the way that GLP-1 works to decrease appetite and promote fullness.
Some people may feel the effects of Saxenda within the first 1-3 days after taking it, but any weight loss is likely not to be noticeable for a little while. Saxenda contains Liraglutide which is a GLP-1 receptor agonist. This means that it works similarly to GLP-1 to decrease appetite and promote fullness."
Answered by AI
Does Saxenda work for weight loss?
"After one year of taking Saxenda®, 56% of patients achieved significant weight loss, and about half of these patients were able to maintain their weight loss for three years when combined with a reduced-calorie meal plan and increased physical activity."
Answered by AI
How quickly do you lose weight with Saxenda?
"Patients can expect to lose at least 5% of their weight within the first 12 weeks of treatment."
Answered by AI
Does Saxenda weight loss work?
"The Saxenda clinical study found that 56% of participants lost significant weight in the first year, and half of those participants were able to maintain their weight loss for the following two years while taking Saxenda and following a reduced-calorie meal plan and increased physical activity."
Answered by AI
What are the side effects of Saxenda?
"Some of the more common side effects that people experience when taking Saxenda® include nausea, diarrhea, constipation, vomiting, reactions at the injection site, low blood sugar levels (hypoglycemia), headaches, tiredness, dizziness, and stomach pain. Another thing that some people may experience is a change in the level of enzymes (lipase) in their blood."
Answered by AI
Is Saxenda just insulin?
"No, Saxenda is not a type of insulin. Insulin is a hormone that helps the body regulate blood sugar levels. Instead, Saxenda is a type of drug called a GLP-1 agonist. GLP-1 is another hormone that helps regulate blood sugar levels."
Answered by AI