What is Sandimmune
CyclosporineThe Generic name of this drug
Treatment SummaryCyclosporine is a drug used to reduce the risk of organ transplant rejection and treat inflammatory and autoimmune conditions. It is derived from a fungus called Beauveria nivea and was originally developed by Sandoz, now known as Novartis. The FDA approved cyclosporine in 1983, and it is now available in several different forms.
Sandimmuneis the brand name
Sandimmune Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sandimmune
Cyclosporine
1983
68
Approved as Treatment by the FDA
Cyclosporine, also known as Sandimmune, is approved by the FDA for 25 uses which include inadequate response to conventional therapy and Psoriasis .inadequate response to conventional therapy
Helps manage inadequate response to conventional therapy
Psoriasis
Helps manage severe Psoriasis
severe, recalcitrant Plaque psoriasis
Helps manage severe, recalcitrant Plaque psoriasis
Heymann Nephritis
Helps manage Glomerulonephritis, Membranous
Therapeutic procedure
contraindication or intolerance to other therapy
Helps manage contraindication or intolerance to other therapy
Bone Marrow
Rheumatoid Arthritis
Used to treat Rheumatoid Arthritis in combination with Methotrexate
Chronic Graft Versus Host Disease
Prophylaxis against heart transplant rejection
Patients who do not adequately respond to methotrexate alone
Helps manage Patients who do not adequately respond to methotrexate alone
Glomerulosclerosis
Helps manage Glomerulosclerosis
Steroid Resistant Nephrotic Syndrome
Helps manage Steroid Resistant Nephrotic Syndrome
Focal Segmental Glomerulosclerosis (FSGS)
Helps manage Focal Segmental Glomerulosclerosis (FSGS)
Nephrotic Syndrome
Helps manage Steroid Dependent Nephrotic Syndrome
Prophylaxis against graft versus host disease
Not responsive to other therapy
Helps manage Not responsive to other therapy
Therapeutic immunosuppression
Bone Marrow Transplantation
Liver
Prophylaxis against stem cell transplant rejection
Kidney Transplantation
Used to treat prophylaxis of renal transplant rejection in combination with Azathioprine
Nephrotic Syndrome
Helps manage Nephrotic Syndrome
Rheumatoid Arthritis
Helps manage severe, active Rheumatoid arthritis
Transplantation
Effectiveness
How Sandimmune Affects PatientsCyclosporine helps to prevent and control serious illnesses related to the immune system, like organ and bone marrow transplants, graft versus host disease, and autoimmune diseases. Common side effects of taking this drug include increased body hair, swollen gums, and high cholesterol. Some people also think that cyclosporine may cause damage to the kidneys.
How Sandimmune works in the bodyCyclosporine works by blocking inflammation in the body. It does this by binding to a receptor inside cells called cyclophilin-1. This stops a process called calcineurin, which normally causes inflammation by activating nuclear factor of activated T cells. This, in turn, stops the production of cytokines, which are proteins that cause inflammation. It also hinders the production of other factors related to T helper cell function. All of these effects work together to reduce inflammation in the body.
When to interrupt dosage
The prescribed measure of Sandimmune is contingent upon the diagnosed condition, including Interstitial Cystitis, Focal Segmental Glomerulosclerosis (FSGS) and Excessive tearing. The amount of dosage fluctuates depending on the mode of delivery (e.g. Liquid - Intravenous or Ophthalmic; Topical) noted in the table underneath.Condition
Dosage
Administration
severe, recalcitrant Plaque psoriasis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Idiopathic Thrombocytopenic Purpura
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Glomerulosclerosis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Kidney Transplantation
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Ulcerative Colitis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Atopic Dermatitis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Prophylaxis against stem cell transplant rejection
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Bulla
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Juvenile arthritis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Excessive tearing
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Kidney Diseases
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Chronic Graft Versus Host Disease
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Disease
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Dry Eye Syndromes
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Interstitial Cystitis
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Bone Marrow Transplantation
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Liver
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Rejection; Transplant, Kidney
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
non-immunocompromised
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Transplantation
50.0 mg, 100.0 mg/mL, , 0.0009 mg/mL, 0.9 mg/mL, 0.1 %, 0.5 mg/mL, 0.09 %, 25.0 mg, 50.0 mg/mL, 100.0 mg, 10.0 mg, 0.05 %, 1.0 mg/mL, 2.5 mg/mL, 0.005 mg/mL
Liquid - Intravenous, Ophthalmic; Topical, Capsule, Solution / drops, Solution / drops - Ophthalmic; Topical, Capsule - Oral, Solution - Ophthalmic, Injection, solution - Intravenous, Oral, , Capsule, liquid filled - Oral, Intravenous, Emulsion - Ophthalmic, Injection, solution, Emulsion, Solution - Intravenous, Ophthalmic, Liquid, Solution, Emulsion - Ophthalmic; Topical, Capsule, liquid filled, Injection, Liquid - Topical, Injection - Intravenous, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution - Oral, Topical, Liquid - Ophthalmic, Liquid - Oral
Warnings
Sandimmune ContraindicationsCondition
Risk Level
Notes
Ocular neoplasms malignancy unspecified
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Hypertensive disease
Do Not Combine
Abnormal Renal Function
Do Not Combine
Psoriasis
Do Not Combine
active periocular infections
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
active ocular infections
Do Not Combine
Pulse Frequency
Do Not Combine
Infection
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Secondary Immunodeficiencies (SID)
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Hypertensive disease
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
Radiation Therapy
Do Not Combine
Abnormal Renal Function
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Cyclosporine may interact with Toxoplasma Infections
Common Sandimmune Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Cyclosporine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Cyclosporine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Cyclosporine.
Aliskiren
Major
The serum concentration of Aliskiren can be increased when it is combined with Cyclosporine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Cyclosporine.
Sandimmune Toxicity & Overdose RiskThe lowest toxic dose of cyclosporine in rats has been found to be 1480mg/kg, while the toxic dose in humans is 12mg/kg. In cases of overdose, it is recommended to induce vomiting and perform gastric lavage up to two hours after ingestion. There is limited information available on overdoses, but potential side effects include hepatotoxicity, nephrotoxicity, nausea, flushing, trembling, vertigo, vomiting, anorexia and feeling of increased body girth. These effects may last for up to two weeks. Dialysis and charcoal hemoperfusion are not effective methods for removing cycl
Sandimmune Novel Uses: Which Conditions Have a Clinical Trial Featuring Sandimmune?
81 active clinical trials are currently underway to assess the potential of Sandimmune in the management of Chronic Graft Versus Host Disease, Renal Pathologies and Ulcerative Colitis.Condition
Clinical Trials
Trial Phases
Chronic Graft Versus Host Disease
32 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Atopic Dermatitis
75 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 1, Phase 2, Early Phase 1
Lupus Nephritis
20 Actively Recruiting
Phase 4, Phase 2, Phase 1, Phase 3
Dry Eye Syndromes
1 Actively Recruiting
Phase 3
Nephrotic Syndrome
0 Actively Recruiting
non-immunocompromised
0 Actively Recruiting
Transplantation
0 Actively Recruiting
Interstitial Cystitis
16 Actively Recruiting
Phase 2, Early Phase 1, Not Applicable, Phase 1, Phase 3
Kidney Diseases
0 Actively Recruiting
Ulcerative Colitis
0 Actively Recruiting
Excessive tearing
0 Actively Recruiting
Bulla
0 Actively Recruiting
Heart
2 Actively Recruiting
Phase 2, Not Applicable
Rejection; Transplant, Kidney
10 Actively Recruiting
Phase 3, Phase 1, Phase 2, Phase 4, Not Applicable, Early Phase 1
Rejection, Transplant
2 Actively Recruiting
Phase 2
severe, recalcitrant Plaque psoriasis
0 Actively Recruiting
Patients who do not adequately respond to methotrexate alone
0 Actively Recruiting
Rheumatoid Arthritis
0 Actively Recruiting
Rejection; Transplant, Liver
0 Actively Recruiting
Therapeutic immunosuppression
0 Actively Recruiting
Sandimmune Reviews: What are patients saying about Sandimmune?
5Patient Review
3/4/20095Patient Review
5/11/2010 I've been taking this medication for a long time and it's served me well.
3Patient Review
2/5/2011 I've been taking this medication for a little over a week now. Almost immediately after starting, I felt really terrible. Severe pain in my arm and headaches that were so bad they made me nauseous. I'm hoping the good effects will start to outweigh the bad soon.
Patient Q&A Section about sandimmune
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does Sandimmune treat?
"Cyclosporine is an immunosuppressant typically used to prevent organ rejection after a transplant. It can also be used to treat severe psoriasis or rheumatoid arthritis."
Answered by AI
What is the generic name for Sandimmune?
"This medication is used to prevent organ rejection after a kidney, heart, or liver transplant. Cyclosporine belongs to a class of drugs called immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.
Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.
The oral capsule form of cyclosporine is available as the brand-name drugs Gengraf, Neoral, and Sandimmune, and as a generic drug. This medication is used to prevent organ rejection after a kidney, heart, or liver transplant. Cyclosporine belongs to a class of drugs called immunosuppressants, which work by weakening the body's defense system (immune system) to help the body accept the new organ as if it were its own. Generic drugs usually cost less than the brand-name versions of the same drug, although they may not be available in every strength or form."
Answered by AI
What drug class is Sandimmune?
"Nonribosomal peptides are usually synthesized by large multienzyme complexes.
Nonribosomal peptides are a type of peptide that is not made by a ribosome. They are found in bacteria, fungi, and other organisms. Nonribosomal peptides are made by large multienzyme complexes."
Answered by AI