Your session is about to expire
What is Ropivacaine Hydrochloride
RopivacaineThe Generic name of this drug
Treatment SummaryRopivacaine is a local anesthetic, commonly sold under the brand name Naropin. It is a mixture of two versions of the drug (S and R) but only the S-enantiomer is used for its anaesthetic properties.
Naropinis the brand name
Ropivacaine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Naropin
Ropivacaine
1996
56
Approved as Treatment by the FDA
Ropivacaine, commonly known as Naropin, is approved by the FDA for 1 uses including Postoperative Pain .Postoperative Pain
Helps manage Postoperative pain
Effectiveness
How Ropivacaine Hydrochloride Affects PatientsRopivacaine is a local anesthetic that is not impacted by epinephrine in terms of how quickly it works, how long it works for, or how much gets absorbed into the body.
How Ropivacaine Hydrochloride works in the bodyRopivacaine helps block the pain signals sent by nerves. It does this by increasing the amount of electrical stimulation needed for a nerve to send a signal, slowing down how quickly the signal is sent and reducing how strong the signal is. Ropivacaine works by preventing sodium from entering the nerve, which stops the nerve from sending a signal. The amount of anesthesia will depend on how thick, myelinated, and fast the nerve is.
When to interrupt dosage
The endorsed measure of Ropivacaine Hydrochloride is contingent upon the determined condition, including Labour, Anesthesia procedures and Acute Pain. The amount of dosage fluctuates as per the method of administration (e.g. Epidural; Perineural or Solution - Epidural; Infiltration) featured in the table beneath.Condition
Dosage
Administration
Postoperative Pain
, 5.0 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 7.5 mg/mL, 15.0 mg/mL, 20.0 mg/mL, 4.0 mg/mL
Parenteral, , Injection, solution, Injection, solution - Parenteral, Injection, solution - Epidural; Infiltration; Perineural, Epidural; Infiltration; Perineural, Epidural, Injection, solution - Epidural, Epidural; Perineural, Injection, solution - Epidural; Perineural, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Liquid, Liquid - Parenteral, Solution, Solution - Epidural; Infiltration, Solution - Epidural, Infiltration, Injection, Injection - Epidural, Injection - Epidural; Infiltration; Perineural, Injection - Epidural; Perineural, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Kit, Injection - Epidural; Infiltration
Anesthesia procedures
, 5.0 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 7.5 mg/mL, 15.0 mg/mL, 20.0 mg/mL, 4.0 mg/mL
Parenteral, , Injection, solution, Injection, solution - Parenteral, Injection, solution - Epidural; Infiltration; Perineural, Epidural; Infiltration; Perineural, Epidural, Injection, solution - Epidural, Epidural; Perineural, Injection, solution - Epidural; Perineural, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Liquid, Liquid - Parenteral, Solution, Solution - Epidural; Infiltration, Solution - Epidural, Infiltration, Injection, Injection - Epidural, Injection - Epidural; Infiltration; Perineural, Injection - Epidural; Perineural, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Kit, Injection - Epidural; Infiltration
Acute Pain
, 5.0 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 7.5 mg/mL, 15.0 mg/mL, 20.0 mg/mL, 4.0 mg/mL
Parenteral, , Injection, solution, Injection, solution - Parenteral, Injection, solution - Epidural; Infiltration; Perineural, Epidural; Infiltration; Perineural, Epidural, Injection, solution - Epidural, Epidural; Perineural, Injection, solution - Epidural; Perineural, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Liquid, Liquid - Parenteral, Solution, Solution - Epidural; Infiltration, Solution - Epidural, Infiltration, Injection, Injection - Epidural, Injection - Epidural; Infiltration; Perineural, Injection - Epidural; Perineural, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Kit, Injection - Epidural; Infiltration
Labour
, 5.0 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 7.5 mg/mL, 15.0 mg/mL, 20.0 mg/mL, 4.0 mg/mL
Parenteral, , Injection, solution, Injection, solution - Parenteral, Injection, solution - Epidural; Infiltration; Perineural, Epidural; Infiltration; Perineural, Epidural, Injection, solution - Epidural, Epidural; Perineural, Injection, solution - Epidural; Perineural, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Liquid, Liquid - Parenteral, Solution, Solution - Epidural; Infiltration, Solution - Epidural, Infiltration, Injection, Injection - Epidural, Injection - Epidural; Infiltration; Perineural, Injection - Epidural; Perineural, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Kit, Injection - Epidural; Infiltration
Warnings
Ropivacaine Hydrochloride ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ropivacaine may interact with Pulse Frequency
Common Ropivacaine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Ropivacaine is combined with Oliceridine.
Technetium Tc-99m tilmanocept
Major
Ropivacaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.
Thalidomide
Major
Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Ropivacaine Hydrochloride Toxicity & Overdose RiskTaking too much ropivacaine can have serious effects on the nervous system and heart. Symptoms may include nervousness, ringing in the ears, trembling, dizziness, blurred vision, seizures, drowsiness, unconsciousness, shallow breathing, low blood pressure, slow heartbeat, irregular heartbeat, and/or cardiac arrest.
Ropivacaine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Ropivacaine Hydrochloride?
30 active trials are currently being conducted to assess the utility of Ropivacaine Hydrochloride in providing Surgical Anesthesia, Acute Pain relief and Anesthetic procedures.Condition
Clinical Trials
Trial Phases
Acute Pain
21 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 1
Labour
2 Actively Recruiting
Phase 4, Phase 3
Postoperative Pain
19 Actively Recruiting
Phase 4, Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2
Anesthesia procedures
0 Actively Recruiting
Patient Q&A Section about ropivacaine hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does ropivacaine injection last?
"The minimum length of time that ropivacaine will provide anesthesia is 3.75 hours, while the maximum duration is 9 hours. The anesthesia will last for a median of 6 hours, with an interquartile range of 5.1 to 7.04 hours."
Answered by AI
What is the difference between lidocaine and ropivacaine?
"The table below compares the onset times of different types of anesthesia. Lidocaine had the quickest onset of anesthesia, with a mean time of 1.3 minutes (range, 1 to 2.7 minutes). Ropivacaine had a mean onset time of 4.5 minutes (range, 3.5 to 5.5 minutes)."
Answered by AI
What is the action of ropivacaine?
"[2]
Ropivacaine works by blocking the influx of sodium ions, which reversibly inhibits the conduction of impulses in nerve fibers. The action is potentiated by the dose-dependent inhibition of potassium channels."
Answered by AI