Quetiapine Fumarate

Schizophrenia, Schizophrenia, Bipolar Disorder + 8 more
Treatment
3 FDA approvals
20 Active Studies for Quetiapine Fumarate

What is Quetiapine Fumarate

QuetiapineThe Generic name of this drug
Treatment SummaryQuetiapine is an antipsychotic drug used to treat schizophrenia, major depression, and bipolar disorder. It was approved by the FDA in 1997 and is known for its effectiveness and low risk of side effects. Quetiapine is a good option for patients who are sensitive to other drugs, such as Clozapine or Olanzapine.
Seroquelis the brand name
image of different drug pills on a surface
Quetiapine Fumarate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Seroquel
Quetiapine
1997
700

Approved as Treatment by the FDA

Quetiapine, also known as Seroquel, is approved by the FDA for 3 uses which include Bipolar 1 Disorder and Bipolar Disorder .
Bipolar 1 Disorder
Used in combination with other therapies
Bipolar Disorder
Used in combination with other therapies
Depression

Effectiveness

How Quetiapine Fumarate Affects PatientsQuetiapine helps improve symptoms of schizophrenia, major depression, and bipolar disorder by acting on the serotonin and dopamine receptors in the brain. However, it is not recommended for children under 10 years of age due to increased risk of suicidal thinking or behavior. In elderly patients, this drug has been linked to increased death rate and should be avoided. It is important to monitor for any signs of suicidality if this drug is prescribed to a young patient.
How Quetiapine Fumarate works in the bodyThe exact way quetiapine works is not known, but scientists think it works by blocking certain receptors in the brain. This might help with schizophrenia symptoms by blocking dopamine and serotonin receptors, and depression symptoms by blocking norepinephrine receptors. It also has side effects like drowsiness, low blood pressure, and a decrease in muscle control, which may be caused by blocking other receptors in the body.

When to interrupt dosage

The recommended dosage of Quetiapine Fumarate is contingent upon the determined condition, such as Mental Depression, Bipolar Disorder and Acute Coryza. The amount likewise shifts as outlined by the procedure of delivery indicated in the table below.
Condition
Dosage
Administration
Acute Coryza
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Schizophrenia
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Generalized Anxiety Disorder
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Parkinson's Disease
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Schizophrenia
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Bipolar Disorder
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Bipolar Disorder
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Behcet Syndrome
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Depression
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Post Traumatic Stress Disorder
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Mental Depression
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
Tablet, extended release, Tablet, extended release - Oral, , Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral

Warnings

There are 20 known major drug interactions with Quetiapine Fumarate.
Common Quetiapine Fumarate Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Quetiapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Quetiapine is combined with Aclidinium.
Alfuzosin
Major
Quetiapine may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Quetiapine may increase the antipsychotic activities of Amisulpride.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Quetiapine is combined with Anagrelide.
Quetiapine Fumarate Toxicity & Overdose RiskThe lowest toxic dose of quetiapine in rats is 2000mg/kg. Signs and symptoms of an overdose may include excessive sleepiness, rapid heartbeat, and low blood pressure. Studies have found that an overdose of up to 30 grams does not usually result in death, although one case of 13.6 grams was fatal. Treatment for overdose includes maintaining an open airway, providing oxygen and ventilation, and stomach pumping with activated charcoal and a laxative. It is important to monitor the heart rate as taking certain drugs concomitantly with quetiapine can increase the QT interval.
image of a doctor in a lab doing drug, clinical research

Quetiapine Fumarate Novel Uses: Which Conditions Have a Clinical Trial Featuring Quetiapine Fumarate?

At present, 705 active trials are assessing the capability of Quetiapine Fumarate to treat Depression, Schizophrenia and Bipolar Disorder.
Condition
Clinical Trials
Trial Phases
Schizophrenia
97 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 2
Depression
213 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1
Post Traumatic Stress Disorder
239 Actively Recruiting
Not Applicable, Early Phase 1, Phase 3, Phase 4, Phase 2, Phase 1
Acute Coryza
1 Actively Recruiting
Not Applicable
Bipolar Disorder
0 Actively Recruiting
Generalized Anxiety Disorder
7 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Parkinson's Disease
39 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1
Mental Depression
2 Actively Recruiting
Phase 2, Not Applicable
Behcet Syndrome
1 Actively Recruiting
Not Applicable
Bipolar Disorder
0 Actively Recruiting
Schizophrenia
31 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4

Quetiapine Fumarate Reviews: What are patients saying about Quetiapine Fumarate?

5Patient Review
9/11/2022
Quetiapine Fumarate for Repeated Episodes of Anxiety
Since taking this medication, I have seen vast improvements in my depression, anger, anxiety and sleep patterns.
5Patient Review
2/21/2022
Quetiapine Fumarate for Bipolar I Disorder with Most Recent Episode Mixed
This drug has really helped mepositively change my life. I'm grateful to the people who make this medicine possible.
4.7Patient Review
5/18/2021
Quetiapine Fumarate for Bipolar Depression
4Patient Review
7/8/2021
Quetiapine Fumarate for Bipolar Depression
Quetiapine has been a lifesaver for me. It's helped stabilize my mood and keep my panic attacks under control. I never feel like a shell of a person when I'm on this medication, which is something I struggled with on other medications. I'm just overall much happier and can appreciate the little things again.
3.7Patient Review
5/28/2021
Quetiapine Fumarate for Schizophrenia
Overall, I really enjoyed this treatment!
3.3Patient Review
9/5/2022
Quetiapine Fumarate for Additional Medications to Treat Depression
I've unfortunately gained a lot of weight since starting this medication, which has only stabilized my mood slightly. It also makes it hard to think clearly and get consistent sleep. Overall, I would not recommend it.
3Patient Review
8/26/2022
Quetiapine Fumarate for Repeated Episodes of Anxiety
One of the side effects I experienced while taking this medication was a loss of balance. It didn't go away after stopping the drug, either. Has anyone else had this problem?
3Patient Review
10/14/2021
Quetiapine Fumarate for Bipolar I Disorder with Most Recent Episode Mixed
I've been taking this pill for a few years now and I'm honestly quite dependent on it.
2.3Patient Review
2/8/2022
Quetiapine Fumarate for Mania associated with Bipolar Disorder
I experienced a lot of side effects from this medication, including muscle pain, weight gain, and kidney problems. I also felt very tired and dizzy from it. Additionally, I found it to be quite addictive.
1.7Patient Review
12/4/2021
Quetiapine Fumarate for Additional Medications to Treat Depression
After taking this medication, I had a full-blown suicide experience where I begged for a car to hit me. My wife had to save me. The same psychiatrist is now trying to give it to me again after 5 years of that incident.
1Patient Review
10/25/2021
Quetiapine Fumarate for Repeated Episodes of Anxiety
The horrible side effects aren't worth any benefits. I felt angry, tired, and my skin was burning and stinging. The next day I felt like a zombie. If you're thinking about trying this drug, beware that it might give you an allergic reaction.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about quetiapine fumarate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the side effects of quetiapine fumarate?

"Dizziness, feeling unsteady, or having trouble keeping your balance can be caused by pain in the joints, back, neck, or ears, weakness, dry mouth, vomiting, indigestion, or constipation."

Answered by AI

What is quetiapine fumarate used for?

"Quetiapine is a medication that can be used to treat bipolar disorder and schizophrenia, either on its own or in combination with other medications. It can also be used in conjunction with other antidepressants to treat major depressive disorder."

Answered by AI

Is quetiapine fumarate a sleeping pill?

"Seroquel is not a medication for sleep aids, but rather a mental health medication that is approved by the FDA to treat psychiatric conditions such as schizophrenia, bipolar disorder, and major depressive disorder."

Answered by AI

Is quetiapine fumarate the same as Xanax?

"Seroquel is an antipsychotic medication and Xanax is a benzodiazepine. Seroquel and Xanax are different medications that are used to treat psychiatric disorders. Seroquel is an antipsychotic medication used to treat schizophrenia, major depression, and bipolar disorder. Xanax is a benzodiazepine used to treat panic attacks and anxiety disorders."

Answered by AI

Clinical Trials for Quetiapine Fumarate

Image of Baylor College of Medicine in Houston, United States.

Stepped Care Treatment for Anxiety

7 - 17
All Sexes
Houston, TX
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed. The stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child. While stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change. This research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.
Waitlist Available
Has No Placebo
Baylor College of Medicine
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Cognitive Rehabilitation for Anger in TBI and PTSD

18+
All Sexes
Durham, NC
This randomized clinical trial will enroll 100 Veteran-family/friend dyads to test the efficacy of CALM in treating anger in TBI and PTSD. The investigators hypothesize that compared to an active control group, Veterans randomized to the CALM group will demonstrate: * Significantly larger decreases in anger dysregulation, impulsivity, and executive dysfunction. * Significantly larger improvements in social and adaptive functioning including less aggression. * Significantly larger reduction in PTSD symptoms and suicidal ideation. The study targets Veterans who experience difficulties with anger and impulsivity due to TBI and PTSD. These issues are common, with up to 38% of Veterans with TBI also having PTSD. These conditions often make it challenging for Veterans to control their emotions and interact successfully in social and work settings. Our research will test the CALM (Cognitive Applications for Life Management) mobile app, which helps Veterans manage their goals, remember important tasks, and improve their attention. Initial tests of CALM have shown it can reduce levels of anger and related issues in Veterans. The investigators will conduct a study with 100 pairings of Veterans and a family member or friend. These pairs will be randomly assigned to one of two groups: one using the CALM mobile platform and the other receiving brain health education. Both groups will use their assigned intervention for three months and will receive support through videoconference calls at the beginning, middle, and end of the program.
Waitlist Available
Has No Placebo
Duke University School of MedicineEric Elbogen
Have you considered Quetiapine Fumarate clinical trials? We made a collection of clinical trials featuring Quetiapine Fumarate, we think they might fit your search criteria.Go to Trials
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Integrated Treatment for PTSD and Chronic Pain

18+
All Sexes
New York, NY
Posttraumatic stress disorder (PTSD) occurs in approximately 7% of adults in the general population. PTSD greatly impacts quality of life and often co-occurs with other conditions such as chronic pain. Individuals with co-morbid PTSD and chronic pain demonstrate higher PTSD symptoms and pain (as well as greater anxiety, depression, disability, and opioid use) compared to those with only one of those conditions. Gold standard treatments exist for both PTSD (e.g., Prolonged Exposure; PE) and chronic pain (e.g., Cognitive Behavioral Therapy for Chronic Pain; CBT-CP) and are generally offered sequentially (i.e., one at a time for the condition that is most prominent). Treating these conditions separately may overlook their interconnected nature, which may reduce efficacy and increase dropout. Thus, there is a need for an intervention to target both simultaneously, which may be more effective and efficient than treating conditions sequentially. This is a single-arm pilot study to assess the feasibility and acceptability of an integrated treatment for adults with comorbid PTSD and chronic pain. The intervention consists of 12 90-minute virtual psychotherapy sessions scheduled twice per week. The treatment draws from modules in PE and CBT-CP including psychoeducation, exposure to feared/avoided situations and activities, processing of exposures, behavioral activation, breathing and relaxation techniques, sleep hygiene, symptom monitoring, and structured homework assignments. Baseline and post-treatment assessments will be conducted.
Waitlist Available
Has No Placebo
Weill Cornell MedicineJoAnn Difede, PhD
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Inhaled Cannabis for PTSD

18+
All Sexes
Cave Creek, AZ
The rationale for the use of inhalational cannabis to potentially treat PTSD symptoms is based on the many reports of cannabis attenuating PTSD symptom expression among individuals with PTSD, including veterans. Study MJP2 is intended to build off MJP-1 through use of a larger sample size, a parallel study design, and subjective bias mitigation methods to re-examine the use of inhaled high THC-containing cannabis versus placebo for management of PTSD symptoms in a U.S. Veteran sample. Together these studies are intended to provide valuable insights on the already widespread use of cannabis in individuals with PTSD, for which there is currently a lack of controlled evidence available reflective of this real-world use.
Phase 2
Waitlist Available
Scottsdale Research Institute
Have you considered Quetiapine Fumarate clinical trials? We made a collection of clinical trials featuring Quetiapine Fumarate, we think they might fit your search criteria.Go to Trials
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Integrated Health Care for Post-Traumatic Stress Disorder

18+
All Sexes
Phoenix, AZ
The goal of this clinical trial is to determine whether which types of integrative care, meaning a combination of psychotherapy and mind-body interventions, lead to the most changes in functioning among Veterans with posttraumatic stress disorder (PTSD). The main aims are: 1. To evaluate the impact of integrative care approaches on functional outcomes among Veterans with PTSD. 2. To examine factors relevant to the implementation of integrated treatments for PTSD from the perspective of patients, providers and administrators in the VA Healthcare System. Participants will: 1. Complete assessments at the beginning of the study and 12- and 24-weeks later. 2. Engage in 12 weeks of integrated care, with the type being randomly assigned.
Waitlist Available
Has No Placebo
VA Phoenix Healthcare System (+4 Sites)
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Peer-Delivered Behavioral Activation for Depression

18+
All Sexes
Detroit, MI
Low-income individuals have limited access to evidence-based interventions for mental health. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, have the potential to increase access to evidence-based interventions for individuals from low-resource communities, particularly when trained and supervised in models that are acceptable and feasible in these communities. This study will examine the effectiveness and implementation potential of a peer-delivered evidence-based intervention (Behavioral Activation) among individuals receiving services from a community-based treatment setting providing integrated physical and behavioral healthcare.
Waitlist Available
Has No Placebo
Detroit Recovery Project
Have you considered Quetiapine Fumarate clinical trials? We made a collection of clinical trials featuring Quetiapine Fumarate, we think they might fit your search criteria.Go to Trials
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