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What is Provigil
ModafinilThe Generic name of this drug
Treatment SummaryModafinil is a stimulant medication used to treat narcolepsy, a sleep disorder. It works by stimulating certain neurons in the brain, leading to an increase in dopamine levels and alertness. The exact way Modafinil works is not fully understood, but research suggests it inhibits the reuptake of dopamine and activates certain glutamate pathways in the brain. Modafinil can produce feelings of increased energy and alertness, as well as euphoria.
Provigilis the brand name
Provigil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Provigil
Modafinil
1998
99
Approved as Treatment by the FDA
Modafinil, also known as Provigil, is approved by the FDA for 3 uses like Obstructive Sleep Apnea and Narcolepsy .Obstructive Sleep Apnea
Narcolepsy
Shift-work related sleep disturbance
Effectiveness
How Provigil Affects PatientsModafinil is a drug that is designed to keep people awake and alert. It's used to treat narcolepsy, a condition that makes people fall asleep suddenly during the day. Modafinil works by activating certain neurons in the brain, which can make people feel more awake and alert. It's not meant to be used to treat normal fatigue or lack of energy, but can be useful for people who suffer from severe drowsiness or hypersomnia. Some studies have also found that modafinil may help people who are recovering from cocaine addiction overcome their cravings.
How Provigil works in the bodyThe exact way that modafinil works is not fully understood, but it has been shown to increase the amount of dopamine in the brain. It does this by blocking the reuptake of dopamine, which means that dopamine stays in the brain for longer. Modafinil also affects glutamate and GABA, two chemicals in the brain, and may activate certain receptors. Unlike other stimulants, modafinil does not cause a pleasurable or euphoric effect and is thought to have less potential for abuse. It is likely that modafinil works through a combination of mechanisms, such as blocking dopamine reuptake and stimulating alpha
When to interrupt dosage
The measure of Provigil is dependent upon the diagnosed state, such as Multiple Sclerosis, Chronic Fatigue Syndrome and Depression. The amount of dosage is contingent upon the technique of delivery (e.g. Tablet - Oral or Oral) outlined in the table beneath.Condition
Dosage
Administration
Shift-work related sleep disturbance
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Depression
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Narcolepsy
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Multiple Sclerosis
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Chronic Fatigue Syndrome
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Obstructive Sleep Apnea
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Attention Deficit Hyperactivity Disorder
, 100.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Provigil.Common Provigil Drug Interactions
Drug Name
Risk Level
Description
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Modafinil.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Modafinil.
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Modafinil.
Cariprazine
Major
The metabolism of Cariprazine can be increased when combined with Modafinil.
Daridorexant
Major
The metabolism of Daridorexant can be increased when combined with Modafinil.
Provigil Novel Uses: Which Conditions Have a Clinical Trial Featuring Provigil?
932 active trials are assessing the potential of Provigil to ameliorate Chronic Fatigue Syndrome, Narcolepsy and Neoplasms.Condition
Clinical Trials
Trial Phases
Shift-work related sleep disturbance
6 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Narcolepsy
10 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4, Phase 1
Multiple Sclerosis
194 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1
Attention Deficit Hyperactivity Disorder
71 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1
Chronic Fatigue Syndrome
87 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1, Phase 4
Obstructive Sleep Apnea
97 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1
Depression
198 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Provigil Reviews: What are patients saying about Provigil?
5Patient Review
6/29/2015 I've been using this for a few months to help with my narcolepsy/EDS and it's been amazing. I have so much more focus and energy, and it's really improved my quality of life. The only downside is that I build up a tolerance very quickly, which can lead to some unpleasant side effects like strange-smelling urine and headaches. But as long as you stay hydrated, you should be fine.
5Patient Review
7/11/2015 I've been using Provigil for three years to help with my narcolepsy, but unfortunately my insurance changed and I can no longer afford the medication.
5Patient Review
1/14/2018 Provigil has been successful in preventing me from involuntarily falling asleep, however I remain drowsy throughout the day. I've been taking it for over a year now.
5Patient Review
11/17/2015 Too expensive for the average person.
5Patient Review
7/4/20144.3Patient Review
2/19/2015 I've tried a few different treatments for my narcolepsy and chronic fatigue syndrome, but this is the one that really works for me. I feel more like myself than I have in years.
4Patient Review
3/18/2022 I take 200mg twice a day. It keeps me from passing out during the day. However, I still feel very tired. It's supposed to last 12 hours. I'd say it's closer to 6.I do get a headache when I take it. Advil/Tylenol/Excedrin doesn't help.Overall this medicine has made my wake time more tolerable; though, it's by no means perfect..
3.7Patient Review
7/17/2017 I'm not sure if it was just me, but I took this and got a really bad headache.
Patient Q&A Section about provigil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does Provigil do to the brain?
"Modafinil, also known as Provigil, is a medication that stimulates the brain. These medications impact the body by speeding up physical and mental processes."
Answered by AI
Does Provigil help you focus?
"Modafinil (brand name Provigil) is a drug that is approved by the FDA to treat sleep disorders like narcolepsy. But a lot of people who use it (for example, students who take it to help them study for exams) use it without a prescription, because they think it might help them focus."
Answered by AI
What is the drug Provigil used for?
"Provigil is a prescription medication used most often to treat excessive sleepiness caused by narcolepsy, obstructive sleep apnea, and shift work. Provigil belongs to a class of medications called stimulants. It is available as 100-mg and 200-mg oral tablets."
Answered by AI
Is Provigil a narcotic?
"Provigil is a schedule IV controlled substance according to the Drug Enforcement Agency because it has the potential to be habit-forming. According to the DEA, patients with a history of substance abuse should use the drug cautiously."
Answered by AI