Provigil

Chronic Fatigue Syndrome, Narcolepsy, Sleep Disorders, Circadian Rhythm + 4 more

Treatment

5 FDA approvals

20 Active Studies for Provigil

Treatment for

Chronic Fatigue Syndrome

What is Provigil

ModafinilThe Generic name of this drug

Treatment SummaryModafinil is a stimulant medication used to treat narcolepsy, a sleep disorder. It works by stimulating certain neurons in the brain, leading to an increase in dopamine levels and alertness. The exact way Modafinil works is not fully understood, but research suggests it inhibits the reuptake of dopamine and activates certain glutamate pathways in the brain. Modafinil can produce feelings of increased energy and alertness, as well as euphoria.

Provigilis the brand name

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Provigil Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Provigil

Modafinil

1998

Approved as Treatment by the FDA

Modafinil, also known as Provigil, is approved by the FDA for 5 uses like Sleep Disorders, Circadian Rhythm and Shift-work related sleep disturbance .

Sleep Disorders, Circadian Rhythm

Shift-work related sleep disturbance

Obstructive Sleep Apnea (OSA)

Narcolepsy

Obstructive Sleep Apnea

Effectiveness

How Provigil Affects PatientsModafinil is a drug that is designed to keep people awake and alert. It's used to treat narcolepsy, a condition that makes people fall asleep suddenly during the day. Modafinil works by activating certain neurons in the brain, which can make people feel more awake and alert. It's not meant to be used to treat normal fatigue or lack of energy, but can be useful for people who suffer from severe drowsiness or hypersomnia. Some studies have also found that modafinil may help people who are recovering from cocaine addiction overcome their cravings.

How Provigil works in the bodyThe exact way that modafinil works is not fully understood, but it has been shown to increase the amount of dopamine in the brain. It does this by blocking the reuptake of dopamine, which means that dopamine stays in the brain for longer. Modafinil also affects glutamate and GABA, two chemicals in the brain, and may activate certain receptors. Unlike other stimulants, modafinil does not cause a pleasurable or euphoric effect and is thought to have less potential for abuse. It is likely that modafinil works through a combination of mechanisms, such as blocking dopamine reuptake and stimulating alpha

When to interrupt dosage

The measure of Provigil is dependent upon the diagnosed state, such as Multiple Sclerosis, Chronic Fatigue Syndrome and Depression. The amount of dosage is contingent upon the technique of delivery (e.g. Tablet - Oral or Oral) outlined in the table beneath.

Condition

Dosage

Administration

Obstructive Sleep Apnea

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Attention Deficit Hyperactivity Disorder

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Multiple Sclerosis

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Sleep Disorders, Circadian Rhythm

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Narcolepsy

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Depression

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Chronic Fatigue Syndrome

, 100.0 mg, 200.0 mg

, Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Provigil.

Common Provigil Drug Interactions

Drug Name

Risk Level

Description

Cabozantinib

Major

The metabolism of Cabozantinib can be decreased when combined with Modafinil.

Capecitabine

Major

The metabolism of Capecitabine can be decreased when combined with Modafinil.

Capmatinib

Major

The serum concentration of Capmatinib can be decreased when it is combined with Modafinil.

Cariprazine

Major

The metabolism of Cariprazine can be increased when combined with Modafinil.

Daridorexant

Major

The metabolism of Daridorexant can be increased when combined with Modafinil.

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Provigil Novel Uses: Which Conditions Have a Clinical Trial Featuring Provigil?

932 active trials are assessing the potential of Provigil to ameliorate Chronic Fatigue Syndrome, Narcolepsy and Neoplasms.

Condition

Clinical Trials

Trial Phases

Attention Deficit Hyperactivity Disorder

65 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1, Early Phase 1

Multiple Sclerosis

120 Actively Recruiting

Phase 3, Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1

Depression

194 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3

Chronic Fatigue Syndrome

45 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4

Obstructive Sleep Apnea

81 Actively Recruiting

Not Applicable, Phase 3, Phase 2, Phase 4, Phase 1, Early Phase 1

Narcolepsy

1 Actively Recruiting

Phase 1

Sleep Disorders, Circadian Rhythm

6 Actively Recruiting

Not Applicable, Phase 2, Phase 3

Provigil Reviews: What are patients saying about Provigil?

5Patient Review

6/29/2015

Provigil for Recurring Sleep Episodes During the Day

I've been using this for a few months to help with my narcolepsy/EDS and it's been amazing. I have so much more focus and energy, and it's really improved my quality of life. The only downside is that I build up a tolerance very quickly, which can lead to some unpleasant side effects like strange-smelling urine and headaches. But as long as you stay hydrated, you should be fine.

5Patient Review

7/11/2015

Provigil for Attention Deficit Disorder with Hyperactivity

I've been using Provigil for three years to help with my narcolepsy, but unfortunately my insurance changed and I can no longer afford the medication.

5Patient Review

1/14/2018

Provigil for Sleepiness Due To Obstructive Sleep Apnea

Provigil has been successful in preventing me from involuntarily falling asleep, however I remain drowsy throughout the day. I've been taking it for over a year now.

5Patient Review

11/17/2015

Provigil for Recurring Sleep Episodes During the Day

Too expensive for the average person.

5Patient Review

7/4/2014

Provigil for Sleepiness Due To Obstructive Sleep Apnea

View All Reviews

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Patient Q&A Section about provigil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Provigil do to the brain?

"Modafinil, also known as Provigil, is a medication that stimulates the brain. These medications impact the body by speeding up physical and mental processes."

Answered by AI

Does Provigil help you focus?

"Modafinil (brand name Provigil) is a drug that is approved by the FDA to treat sleep disorders like narcolepsy. But a lot of people who use it (for example, students who take it to help them study for exams) use it without a prescription, because they think it might help them focus."

Answered by AI

What is the drug Provigil used for?

"Provigil is a prescription medication used most often to treat excessive sleepiness caused by narcolepsy, obstructive sleep apnea, and shift work. Provigil belongs to a class of medications called stimulants. It is available as 100-mg and 200-mg oral tablets."

Answered by AI

Is Provigil a narcotic?

"Provigil is a schedule IV controlled substance according to the Drug Enforcement Agency because it has the potential to be habit-forming. According to the DEA, patients with a history of substance abuse should use the drug cautiously."

Answered by AI

Clinical Trials for Provigil

Have you considered Provigil clinical trials? We made a collection of clinical trials featuring Provigil, we think they might fit your search criteria.

Have you considered Provigil clinical trials? We made a collection of clinical trials featuring Provigil, we think they might fit your search criteria.