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What is Phenytek
PhenytoinThe Generic name of this drug
Treatment SummaryPhenytoin is a type of medication used to control seizures. It has been used for more than 80 years and is one of the most commonly prescribed anti-epileptic drugs. It is also sometimes used to treat conditions such as bipolar disorder and to promote wound healing. It is important to monitor the patient’s response to phenytoin because small changes in the dose can lead to side effects. It is available in both pill form and as an injection.
Dilantin-125is the brand name
Phenytek Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dilantin-125
Phenytoin
1953
163
Approved as Treatment by the FDA
Phenytoin, otherwise known as Dilantin-125, is approved by the FDA for 3 uses which include Status; Epilepticus, Tonic-clonic and Neurosurgery .Status; Epilepticus, Tonic-clonic
Neurosurgery
Epilepsy
Effectiveness
How Phenytek Affects PatientsPhenytoin is a drug used to treat seizures. It usually works best when the level of the drug in the body is between 10-20 mg/L, but this can be tricky to achieve due to differences in genetics, weight, and other medical conditions. Genetic factors like certain types of CYP2C9 and CYP2C19 can affect how quickly the body gets rid of the drug. Phenytoin is mainly bound to proteins in the body, and only the unbound part has an effect. Taking other drugs that bind to the same proteins as phenytoin can also affect its effectiveness.
How Phenytek works in the bodyPhenytoin is a drug used to treat seizures. It works by blocking sodium channels in the brain and preventing a chain reaction of signals that can lead to high frequency action potentials - the kind that cause seizures. This was first observed in the 1980's, although phenytoin had been in use since 1946. It works on almost all types of sodium channels.
When to interrupt dosage
The measure of Phenytek is contingent upon the identified disorder, including Seizure Disorder, Post Traumatic, Seizures and Status; Epilepticus, Tonic-clonic. The amount of dosage shifts, depending on the technique of delivery (e.g. Tablet - Oral or Parenteral) featured in the following table.Condition
Dosage
Administration
Petit Mal Epilepsy
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Seizure Disorder, Post Traumatic
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Neurosurgery
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
inadequate control with monotherapy
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Complex Partial Seizures
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Seizures
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Status Epilepticus
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
convulsive disorders
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Jacksonian epilepsy
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Epilepsy
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Status; Epilepticus, Tonic-clonic
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Temporal Lobe Epilepsy (TLE)
, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Capsule, Capsule - Oral, Suspension - Oral, Suspension, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution - Intramuscular; Intravenous, Solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral
Warnings
Phenytek has eight contraindications, and its use must be avoided when any of the conditions in the following table are present.Phenytek ContraindicationsCondition
Risk Level
Notes
Adams-Stokes Syndrome
Do Not Combine
third degree AV block
Do Not Combine
Pulse Frequency
Do Not Combine
Sinus Bradycardia
Do Not Combine
phenytoin
Do Not Combine
Sinoatrial Block
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Phenytoin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Phenytoin may interact with Pulse Frequency
Common Phenytek Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Phenytoin.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Phenytoin.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Phenytoin.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be increased when combined with Phenytoin.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Phenytoin.
Phenytek Toxicity & Overdose RiskPhenytoin toxicity may occur due to drug interactions, conditions that affect the body's ability to process the drug (like kidney disease), pregnancy, malnutrition, or cancer. Depending on how it is taken, phenytoin toxicity can affect the cardiovascular or nervous system. Neurological side effects, such as nystagmus, slurred speech, tremor, nausea, vomiting, ataxia, confusion, agitation, coma, and seizures, can occur at certain levels of phenytoin in the blood. Cardiovascular side effects, such as abnormal heart rhythms and heart failure, can occur due to phenytoin
Phenytek Novel Uses: Which Conditions Have a Clinical Trial Featuring Phenytek?
Presently, 57 active studies are being conducted to assess the potential of Phenytek in the management of Complex Partial Seizures, Petit Mal Epilepsy and convulsive afflictions.Condition
Clinical Trials
Trial Phases
Seizures
2 Actively Recruiting
Phase 3
Epilepsy
54 Actively Recruiting
Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4, Early Phase 1
Status; Epilepticus, Tonic-clonic
0 Actively Recruiting
Status Epilepticus
0 Actively Recruiting
Neurosurgery
1 Actively Recruiting
Early Phase 1
Complex Partial Seizures
0 Actively Recruiting
Petit Mal Epilepsy
0 Actively Recruiting
inadequate control with monotherapy
0 Actively Recruiting
Seizure Disorder, Post Traumatic
0 Actively Recruiting
convulsive disorders
0 Actively Recruiting
Temporal Lobe Epilepsy (TLE)
1 Actively Recruiting
Phase 1
Jacksonian epilepsy
0 Actively Recruiting
Phenytek Reviews: What are patients saying about Phenytek?
5Patient Review
7/31/2009 Phenytek has been a godsend. Prior to taking this medication, I was having seizures much more frequently. They've become less intense and less frequent since starting the regimen, to the point where I'm hardly even aware of them happening anymore.
5Patient Review
6/2/2009 I love how once-daily dosing is with this drug; it's so easy to remember. I definitely feel more alert and capable since starting treatment.
5Patient Review
8/20/2009 I've only had one seizure in the past five years since I started taking this medication at bedtime.
5Patient Review
9/14/2009 This medication has really helped me and it's so much easier to remember to take just two capsules at bedtime.
5Patient Review
2/8/2010 This medication has done wonders for my seizure disorder. It's so much easier to take just one dose a day, and I've noticed a significant decrease in the frequency and severity of my seizures since switching to this med.
5Patient Review
9/9/2009 Diltin really helped me out and I'm grateful to the doctor for prescribing it.
5Patient Review
5/10/2008 Have been using it to treat migraines with excellant success.
5Patient Review
10/23/20075Patient Review
12/15/20075Patient Review
4/29/2008 Avoid heartburn by making sure you take this medication with food in your stomach, and not immediately before bed.
5Patient Review
5/6/2009 This medication decreases the body's absorption of folic acid and B-12 vitamins.
Patient Q&A Section about phenytek
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name of DILANTIN?
"Phenytoin is an anti-seizure medication that is available both under generic and brand names. Common brand names for phenytoin include Dilantin, but the drug is also sold using the name phenytoin or phenytoin sodium."
Answered by AI
What is Phenytek used for?
"Phenytoin is used as an anticonvulsant or antiepileptic drug to prevent and control seizures. It works by reducing the spread of seizure activity in the brain."
Answered by AI
What is DILANTIN used for?
"DILANTIN is used to treat tonic-clonic and psychomotor seizures. It can also prevent and treat seizures that occur during or after brain surgery."
Answered by AI
What is the side effect of phenytoin?
"Brushing and flossing your teeth and visiting the dentist regularly may help prevent this.
The following text states potential side effects of a certain medication. The side effects listed are headache, nausea, vomiting, constipation, dizziness, feeling of spinning, drowsiness, trouble sleeping, or nervousness. It also states that phenytoin may cause swelling and bleeding of the gums, but that brushing and flossing teeth and visiting the dentist regularly may help prevent this."
Answered by AI