Phenytek

Neurosurgery, Epilepsy, Seizures + 9 more

Treatment

5 FDA approvals

20 Active Studies for Phenytek

What is Phenytek

Phenytoin

The Generic name of this drug

Treatment Summary

Phenytoin is a type of medication used to control seizures. It has been used for more than 80 years and is one of the most commonly prescribed anti-epileptic drugs. It is also sometimes used to treat conditions such as bipolar disorder and to promote wound healing. It is important to monitor the patient’s response to phenytoin because small changes in the dose can lead to side effects. It is available in both pill form and as an injection.

Dilantin-125

is the brand name

image of different drug pills on a surface

Phenytek Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Dilantin-125

Phenytoin

1953

163

Approved as Treatment by the FDA

Phenytoin, otherwise known as Dilantin-125, is approved by the FDA for 5 uses which include Seizures and Status; Epilepticus, Tonic-clonic .

Seizures

Status; Epilepticus, Tonic-clonic

Seizures

Neurosurgery

Epilepsy

Effectiveness

How Phenytek Affects Patients

Phenytoin is a drug used to treat seizures. It usually works best when the level of the drug in the body is between 10-20 mg/L, but this can be tricky to achieve due to differences in genetics, weight, and other medical conditions. Genetic factors like certain types of CYP2C9 and CYP2C19 can affect how quickly the body gets rid of the drug. Phenytoin is mainly bound to proteins in the body, and only the unbound part has an effect. Taking other drugs that bind to the same proteins as phenytoin can also affect its effectiveness.

How Phenytek works in the body

Phenytoin is a drug used to treat seizures. It works by blocking sodium channels in the brain and preventing a chain reaction of signals that can lead to high frequency action potentials - the kind that cause seizures. This was first observed in the 1980's, although phenytoin had been in use since 1946. It works on almost all types of sodium channels.

When to interrupt dosage

The measure of Phenytek is contingent upon the identified disorder, including Seizure Disorder, Post Traumatic, Seizures and Status; Epilepticus, Tonic-clonic. The amount of dosage shifts, depending on the technique of delivery (e.g. Tablet - Oral or Parenteral) featured in the following table.

Condition

Dosage

Administration

Epilepsy

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Neurosurgery

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Seizures

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Epilepsy, Absence

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Seizures

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Seizures

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Status Epilepticus

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

inadequate control with monotherapy

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Epilepsy, Post-Traumatic

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Epilepsy

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Seizures

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Epilepsy, Temporal Lobe

, 30.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 50.0 mg, 50.0 mg/mL, 125.0 mg/mL, 100.0 mg/mL, 250.0 mg/mL, 30.0 mg/mL

Oral, , Capsule, extended release - Oral, Capsule, extended release, Tablet, chewable, Tablet, chewable - Oral, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Capsule, Capsule - Oral, Suspension, Suspension - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, Tablet - Oral, Solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Injection - Intramuscular; Intravenous, Parenteral, Injection - Parenteral

Warnings

Phenytek has eight contraindications, and its use must be avoided when any of the conditions in the following table are present.

Phenytek Contraindications

Condition

Risk Level

Notes

Adams-Stokes Syndrome

Do Not Combine

Atrioventricular Block

Do Not Combine

Pulse Frequency

Do Not Combine

Sinus Bradycardia

Do Not Combine

phenytoin

Do Not Combine

Sinoatrial Block

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Phenytoin may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Phenytoin may interact with Pulse Frequency

There are 20 known major drug interactions with Phenytek.

Common Phenytek Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Phenytoin.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Phenytoin.

5-androstenedione

Major

The metabolism of 5-androstenedione can be increased when combined with Phenytoin.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Phenytoin.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Phenytoin.

Phenytek Toxicity & Overdose Risk

Phenytoin toxicity may occur due to drug interactions, conditions that affect the body's ability to process the drug (like kidney disease), pregnancy, malnutrition, or cancer. Depending on how it is taken, phenytoin toxicity can affect the cardiovascular or nervous system. Neurological side effects, such as nystagmus, slurred speech, tremor, nausea, vomiting, ataxia, confusion, agitation, coma, and seizures, can occur at certain levels of phenytoin in the blood. Cardiovascular side effects, such as abnormal heart rhythms and heart failure, can occur due to phenytoin

image of a doctor in a lab doing drug, clinical research

Phenytek Novel Uses: Which Conditions Have a Clinical Trial Featuring Phenytek?

Presently, 57 active studies are being conducted to assess the potential of Phenytek in the management of Complex Partial Seizures, Petit Mal Epilepsy and convulsive afflictions.

Condition

Clinical Trials

Trial Phases

Seizures

5 Actively Recruiting

Phase 3, Phase 2, Phase 1

Epilepsy, Absence

0 Actively Recruiting

Status Epilepticus

0 Actively Recruiting

Epilepsy

19 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4, Phase 1

Epilepsy, Post-Traumatic

0 Actively Recruiting

Seizures

0 Actively Recruiting

Seizures

0 Actively Recruiting

Neurosurgery

1 Actively Recruiting

Early Phase 1

Epilepsy, Temporal Lobe

4 Actively Recruiting

Not Applicable, Early Phase 1, Phase 1, Phase 2

Epilepsy

0 Actively Recruiting

inadequate control with monotherapy

0 Actively Recruiting

Seizures

0 Actively Recruiting

Phenytek Reviews: What are patients saying about Phenytek?

5

Patient Review

7/31/2009

Phenytek for Convulsive Seizures

Phenytek has been a godsend. Prior to taking this medication, I was having seizures much more frequently. They've become less intense and less frequent since starting the regimen, to the point where I'm hardly even aware of them happening anymore.

5

Patient Review

6/2/2009

Phenytek for Prevention of Seizures following Head Injury or Surgery

I love how once-daily dosing is with this drug; it's so easy to remember. I definitely feel more alert and capable since starting treatment.

5

Patient Review

8/20/2009

Phenytek for Epileptic Seizure

I've only had one seizure in the past five years since I started taking this medication at bedtime.

5

Patient Review

9/14/2009

Phenytek for Convulsive Seizures

This medication has really helped me and it's so much easier to remember to take just two capsules at bedtime.

5

Patient Review

2/8/2010

Phenytek for Convulsive Seizures

This medication has done wonders for my seizure disorder. It's so much easier to take just one dose a day, and I've noticed a significant decrease in the frequency and severity of my seizures since switching to this med.

5

Patient Review

9/9/2009

Phenytek for Epileptic Seizure

Diltin really helped me out and I'm grateful to the doctor for prescribing it.

5

Patient Review

5/10/2008

Phenytek for Epileptic Seizure

Have been using it to treat migraines with excellant success.

5

Patient Review

10/23/2007

Phenytek for Epileptic Seizure

5

Patient Review

12/15/2007

Phenytek for Epileptic Seizure

5

Patient Review

4/29/2008

Phenytek for Epileptic Seizure

Avoid heartburn by making sure you take this medication with food in your stomach, and not immediately before bed.

5

Patient Review

5/6/2009

Phenytek for Epileptic Seizure

This medication decreases the body's absorption of folic acid and B-12 vitamins.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about phenytek

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name of DILANTIN?

"Phenytoin is an anti-seizure medication that is available both under generic and brand names. Common brand names for phenytoin include Dilantin, but the drug is also sold using the name phenytoin or phenytoin sodium."

Answered by AI

What is Phenytek used for?

"Phenytoin is used as an anticonvulsant or antiepileptic drug to prevent and control seizures. It works by reducing the spread of seizure activity in the brain."

Answered by AI

What is DILANTIN used for?

"DILANTIN is used to treat tonic-clonic and psychomotor seizures. It can also prevent and treat seizures that occur during or after brain surgery."

Answered by AI

What is the side effect of phenytoin?

"Brushing and flossing your teeth and visiting the dentist regularly may help prevent this.

The following text states potential side effects of a certain medication. The side effects listed are headache, nausea, vomiting, constipation, dizziness, feeling of spinning, drowsiness, trouble sleeping, or nervousness. It also states that phenytoin may cause swelling and bleeding of the gums, but that brushing and flossing teeth and visiting the dentist regularly may help prevent this."

Answered by AI

Clinical Trials for Phenytek

Image of University of Texas Southwestern Medical Center in Dallas, United States.

Cobenfy KarXT for Memory Loss

18 - 75
All Sexes
Dallas, TX

The goal of this study is to learn about the effects of Cobenfy KarXT (xanomeline and trospium chloride) on episodic memory processing, including specific effects on areas of the brain involved in memory and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed. The main questions it aims to answer are 1) whether Cobenfy KarXT changes memory activity based on its agonist effect on muscarinic receptors and acetylcholine, and 2) what the nature of these brain activity changes are. This work builds on previous experiments evaluating cholinergic antagonists. Participants will complete two treatment arms. One of these will be with the drug, and the other will be with a placebo pill, so that the participants are unaware which session the actual drug has been received. Patients will complete a verbal serial recall and/or associative recognition task each of the two days. An anesthesiologist or patient nurse will administer either the drug or the placebo at a critical point which addresses both of the research questions. Researchers will compare the brain activity between the two treatment arms to determine what brain activity changes, and whether there is an additional behavioral effect on memory.

Phase < 1
Waitlist Available

University of Texas Southwestern Medical Center

Bradley C Lega, MD

Have you considered Phenytek clinical trials?

We made a collection of clinical trials featuring Phenytek, we think they might fit your search criteria.
Go to Trials
Image of Peter S. Allen MRI Unit in Edmonton, Canada.

Enhanced MRI Imaging for Epilepsy

18 - 64
All Sexes
Edmonton, Canada

Temporal lobe epilepsy (TLE) is a common type of epilepsy and one of the most likely to not be controlled by medication. For patients who do not respond to medication, surgery can result in a cure of seizures. Given the fact that around 50% of patients who undergo surgery are seizure free at 10 years there is a need to improve the understanding of what factors best predict surgical outcomes in order to improve our ability to select candidates for surgery. The demonstration of abnormalities in the temporal lobe on MRI is one of the best predictors of seizure free surgical outcomes. Recent studies suggest that changes in specific subregions of the hippocampus could be the strongest predictors of surgical success, however the small size of these regions, (millimeters) make them very difficult to study with standard clinical MRI. Recently new MRI methods have been developed at Wayne State University to image hippocampal blood vessels using ferumoxytol infusion. Feraheme (ferumoxytol) is a drug that is approved in the United States for the treatment of iron deficiency anemia and is currently being studied as an MRI contrast agent in 8 active clinical trials in the United States as well as a Parkinson's Disease study in Canada.

Phase 2
Recruiting

Peter S. Allen MRI Unit

Donald Gross, MD

Have you considered Phenytek clinical trials?

We made a collection of clinical trials featuring Phenytek, we think they might fit your search criteria.
Go to Trials
Image of Duke University Health Sustem in Durham, United States.

Factors Affecting Oxygen Toxicity

18 - 45
All Sexes
Durham, NC

The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are: * How does the training of respiratory muscles affect oxygen toxicity? * How do environmental factors, such as sleep deprivation, the ingestion of commonly utilized medications, and chronic exposure to carbon dioxide, impact the risk of oxygen toxicity? * How does immersion in water affect the development of oxygen toxicity? Participants will be asked to do the following: * Undergo a basic screening exam composed of health history, vital signs, and some respiratory function tests * Train their respiratory muscles at regular intervals * Exercise on a cycle ergometer both in dry conditions and underwater/under pressure in the context of medication, sleep deprivation, or carbon dioxide exposure Researchers will compare the performance of each subject before and after the possible interventions described above to see if there are changes in exercise performance, respiratory function, cerebral blood flow, and levels of gene expression.

Recruiting
Has No Placebo

Duke University Health Sustem

Derek B Covington, MD

Have you considered Phenytek clinical trials?

We made a collection of clinical trials featuring Phenytek, we think they might fit your search criteria.
Go to Trials