Paliperidone

Schizophrenia, Schizoaffective Disorder, Antidepressants + 3 more
Treatment
20 Active Studies for Paliperidone

What is Paliperidone

PaliperidoneThe Generic name of this drug
Treatment SummaryPaliperidone is a medication used to treat schizophrenia. It is a metabolite of risperidone, but the exact mechanism of action is unknown. Paliperidone works by blocking dopamine, serotonin, and other receptors in the brain that are associated with schizophrenia. It was approved by the FDA in 2006 and is available in tablet form, as a once-monthly injection, an every-three-month injection, and a twice-yearly gluteal injection.
Invegais the brand name
image of different drug pills on a surface
Paliperidone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Invega
Paliperidone
2006
81

Effectiveness

How Paliperidone Affects PatientsPaliperidone is an antipsychotic medicine created by Janssen Pharmaceutica. It is a modified form of the older antipsychotic drug risperidone. The exact way it works is not known, but it is thought to work in a similar way as risperidone.
How Paliperidone works in the bodyPaliperidone is the active form of risperidone. The exact way it works to treat schizophrenia is not known, but it is thought to be due to blocking two different types of receptors in the brain: dopamine type 2 and serotonin type 2.

When to interrupt dosage

The recommended measure of Paliperidone is contingent on the identified circumstance, such as Therapeutic procedure, Schizophrenia and Mood stabilizing agents. The dosage will differ depending on the technique of delivery featured in the table below.
Condition
Dosage
Administration
Schizophrenia
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Schizoaffective Disorder
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Therapeutic procedure
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Therapeutic procedure
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Mood stabilizing agents
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Antidepressants
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular

Warnings

There are 20 known major drug interactions with Paliperidone.
Common Paliperidone Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Paliperidone.
Acepromazine
Major
Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alfuzosin
Major
Paliperidone may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Paliperidone may increase the antipsychotic activities of Amisulpride.
Aripiprazole lauroxil
Major
Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Paliperidone Toxicity & Overdose RiskTaking too much of this medication may lead to confusion, seizures, or uncontrollable movements in the head and neck. These side effects could cause someone to choke if they vomit after taking an overdose.
image of a doctor in a lab doing drug, clinical research

Paliperidone Novel Uses: Which Conditions Have a Clinical Trial Featuring Paliperidone?

221 active studies are currently assessing the potential of Paliperidone to provide relief of Schizoaffective Disorder, Schizophrenia and Mood stabilizing effects.
Condition
Clinical Trials
Trial Phases
Mood stabilizing agents
0 Actively Recruiting
Antidepressants
0 Actively Recruiting
Schizoaffective Disorder
52 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1, Phase 3
Therapeutic procedure
0 Actively Recruiting
Schizophrenia
175 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Therapeutic procedure
0 Actively Recruiting

Paliperidone Reviews: What are patients saying about Paliperidone?

5Patient Review
9/24/2017
Paliperidone for Schizophrenia With Mood Changes
Out of all the antipsychotics I've tried, this one has been the most effective for me. I don't experience hallucinations as often and my mood is stable. The worst side effect is the flat affect but it's manageable. Overall, I would say this is the best option out there.
4.7Patient Review
5/10/2012
Paliperidone for Schizophrenia With Mood Changes
This treatment effectively removed my headache and the associated dizziness.
4.3Patient Review
2/23/2017
Paliperidone for Schizophrenia With Mood Changes
I did experience some weight gain and dry mouth while on this medication. However, it was worth it because I was finally able to get up in the morning without feeling exhausted.
4Patient Review
12/22/2013
Paliperidone for Schizophrenia
This medication has helped me a lot. I've tried other meds in the past (e.g. risperidone), but they didn't work as well for me. This combination of medications has allowed me to feel better and think more positively.
4Patient Review
12/10/2008
Paliperidone for Manic-Depression
I think it's helped me lose weight and I don't have as much muscle fatigue. I also don't talk to myself as much, which is a plus!
3.7Patient Review
9/22/2008
Paliperidone for Mania associated with Bipolar Disorder
My son was given this medication and it caused some very concerning side effects. He was extremely hyper and then the complete opposite - shaking and drowsy. We had to stop giving it to him.
3.3Patient Review
10/23/2007
Paliperidone for Additional Medications to Treat Depression
3.3Patient Review
5/30/2008
Paliperidone for Bipolar I Disorder with Most Recent Episode Mixed
3.3Patient Review
5/30/2016
Paliperidone for Psychosis caused by a Disease
I experienced some negative side effects while taking this medication, including mood changes, headaches, dizziness, and weakness.
1Patient Review
4/15/2019
Paliperidone for Additional Medications to Treat Depression
I've found this medication to be totally life-changing in the best way possible.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about paliperidone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does paliperidone do to the brain?

"Paliperidone helps to treat schizophrenia by blocking the receptors for the neurotransmitters dopamine and serotonin. By doing this, it helps to normalise the activity of the brain and reduce symptoms."

Answered by AI

What is paliperidone used to treat?

"This medication is used to treat the symptoms of mental disorders such as schizophrenia. It can also be used by itself or with other medications to treat patients with schizoaffective disorder. Do not give this medicine to elderly patients who have dementia and are exhibiting behavioral problems."

Answered by AI

What are side effects of paliperidone?

"The following are side effects that may occur when you receive a vaccine: pain, swelling, or redness at the injection site; extreme tiredness; dizziness, feeling unsteady, or having trouble keeping your balance; restlessness; agitation; headache; dry mouth; or weight gain."

Answered by AI

What happens when you take paliperidone?

"Paliperidone belongs to a class of drugs called atypical antipsychotics.

This drug is used to treat mental and mood disorders such as schizophrenia and schizoaffective disorder. It can help to decrease hallucinations, think more clearly and positively, feel less agitated, and take a more active part in everyday life. Paliperidone belongs to a class of drugs known as atypical antipsychotics."

Answered by AI

Clinical Trials for Paliperidone

Have you considered Paliperidone clinical trials? We made a collection of clinical trials featuring Paliperidone, we think they might fit your search criteria.
Have you considered Paliperidone clinical trials? We made a collection of clinical trials featuring Paliperidone, we think they might fit your search criteria.
Have you considered Paliperidone clinical trials? We made a collection of clinical trials featuring Paliperidone, we think they might fit your search criteria.
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