Nateglinide

Type 2 Diabetes
Treatment
2 FDA approvals
20 Active Studies for Nateglinide

What is Nateglinide

NateglinideThe Generic name of this drug
Treatment SummaryNateglinide is a prescription medication used to treat non-insulin-dependent diabetes. It is a short-acting insulin secretagogue that helps to lower fasting and postprandial (after meal) blood sugar levels. Nateglinide should be taken with meals and missed doses should be skipped whenever a meal is missed. The medication can take up to a month to start showing effects, such as reducing fasting blood glucose, and may cause a slight increase in weight in people who have not taken other oral antidiabetic medications. Nateglinide may cause hypoglycemia, but this risk is thought to be lower than
Starlixis the brand name
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Nateglinide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Starlix
Nateglinide
2000
40

Approved as Treatment by the FDA

Nateglinide, also called Starlix, is approved by the FDA for 2 uses including Type 2 Diabetes Mellitus and Type 2 Diabetes .
Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus

Effectiveness

How Nateglinide Affects PatientsInsulin is controlled by the electrical activity of cells in the pancreas. When glucose from the blood enters these cells, it is turned into ATP. When there is a lot of ATP, it makes the cell's electrical activity decrease. When there is little glucose, the cell's electrical activity increases. Nateglinide helps to increase insulin release by stopping the electrical activity from decreasing when there is a lot of glucose. This causes more insulin to be released into the body.
How Nateglinide works in the bodyNateglinide is a drug that works by helping your body's beta cells release insulin when you eat. It doesn't work if there is no glucose present, so it won't affect your insulin levels between meals or overnight. It is most effective in reducing blood glucose levels after a meal, but it can take up to a month to see decreases in fasting blood glucose. Nateglinide is only effective at intermediate glucose levels (3-10 mmol/L) and won't work if your glucose levels are too high (over 15 mmol/L). It is also selective for pancreatic beta cells and does not affect other parts of

When to interrupt dosage

The measure of Nateglinide is contingent upon the diagnosed malady. The amount of dosage can be found in the table shown below, depending on the technique of delivery (e.g. Tablet, film coated - Oral or Tablet).
Condition
Dosage
Administration
Type 2 Diabetes
, 60.0 mg, 120.0 mg, 180.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Nateglinide has two limitations. Using it is not recommended for the conditions enumerated in the following table.Nateglinide Contraindications
Condition
Risk Level
Notes
Diabetic Ketoacidosis
Do Not Combine
Type 1 Diabetes
Do Not Combine
There are 20 known major drug interactions with Nateglinide.
Common Nateglinide Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Nateglinide.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Nateglinide.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Nateglinide.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Nateglinide.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Nateglinide.
Nateglinide Toxicity & Overdose RiskTaking too much of this medication can lead to low blood sugar levels, resulting in symptoms such as dizziness, confusion, sweating, and hunger.
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Nateglinide Novel Uses: Which Conditions Have a Clinical Trial Featuring Nateglinide?

162 active studies are currently investigating the efficacy of Nateglinide in managing Type 2 Diabetes.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
175 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Nateglinide Reviews: What are patients saying about Nateglinide?

5Patient Review
8/19/2011
Nateglinide for Type 2 Diabetes Mellitus
I had to stop taking this in 2004 because it caused my blood sugar levels to drop too low. However, it's the only oral diabetic drug that I can take without having bad reactions (I'm part of the 1%). So far, since starting back on it in March, I haven't had any problems.
5Patient Review
11/4/2009
Nateglinide for Type 2 Diabetes Mellitus
4Patient Review
9/10/2012
Nateglinide for Type 2 Diabetes Mellitus
I switched to this pill from Actos at my doctor's suggestion, and I'm really happy with it. My readings are better than they were on Actos, and it's cheaper too!
3.7Patient Review
3/23/2012
Nateglinide for Type 2 Diabetes Mellitus
I unfortunately had to discontinue this medication after only thirteen days due to the extreme constipation it caused me. I was taking laxatives two times a day just to be able to go!
3.3Patient Review
2/21/2013
Nateglinide for Type 2 Diabetes Mellitus
I've been taking it for about 6 months and it tends to bring my blood sugar down too much. I also take metoformin with it. I have to watch my sugar every 2 hours to be sure I havent dropped too low after a meal.
View All Reviews
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Patient Q&A Section about nateglinide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

When should nateglinide be given?

"It is important to take nateglinide exactly as your doctor tells you to. The usual dose is one tablet three times daily, before your main meals (usually breakfast, lunch and dinner), taken either immediately before or up to 30 minutes before a meal."

Answered by AI

What class is nateglinide?

"Nateglinide is a meglitinide, a class of drug that helps the body regulate the amount of glucose in the blood. It does this by stimulating the pancreas to release insulin, decreasing the amount of glucose in the blood."

Answered by AI

Is nateglinide the same as metformin?

"The study showed that nateglinide and metformin monotherapy can both improve glycemic control, although they do so in different ways. Nateglinide decreases the fluctuations in blood sugar levels that occur after meals, while metformin primarily affects fasting blood sugar levels."

Answered by AI

What is the medication nateglinide used for?

"Nateglinide is used to help control blood sugar levels in patients with type 2 diabetes, when combined with diet and exercise. It works by causing your pancreas to release more insulin into the blood stream. Patients who have insulin-dependent or type 1 diabetes will not see any benefits from this medicine."

Answered by AI

Clinical Trials for Nateglinide

Have you considered Nateglinide clinical trials? We made a collection of clinical trials featuring Nateglinide, we think they might fit your search criteria.
Have you considered Nateglinide clinical trials? We made a collection of clinical trials featuring Nateglinide, we think they might fit your search criteria.
Have you considered Nateglinide clinical trials? We made a collection of clinical trials featuring Nateglinide, we think they might fit your search criteria.
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