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What is Nateglinide
NateglinideThe Generic name of this drug
Treatment SummaryNateglinide is a prescription medication used to treat non-insulin-dependent diabetes. It is a short-acting insulin secretagogue that helps to lower fasting and postprandial (after meal) blood sugar levels. Nateglinide should be taken with meals and missed doses should be skipped whenever a meal is missed. The medication can take up to a month to start showing effects, such as reducing fasting blood glucose, and may cause a slight increase in weight in people who have not taken other oral antidiabetic medications. Nateglinide may cause hypoglycemia, but this risk is thought to be lower than
Starlixis the brand name
Nateglinide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Starlix
Nateglinide
2000
40
Approved as Treatment by the FDA
Nateglinide, also called Starlix, is approved by the FDA for 1 uses including Type 2 Diabetes .Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Effectiveness
How Nateglinide Affects PatientsInsulin is controlled by the electrical activity of cells in the pancreas. When glucose from the blood enters these cells, it is turned into ATP. When there is a lot of ATP, it makes the cell's electrical activity decrease. When there is little glucose, the cell's electrical activity increases. Nateglinide helps to increase insulin release by stopping the electrical activity from decreasing when there is a lot of glucose. This causes more insulin to be released into the body.
How Nateglinide works in the bodyNateglinide is a drug that works by helping your body's beta cells release insulin when you eat. It doesn't work if there is no glucose present, so it won't affect your insulin levels between meals or overnight. It is most effective in reducing blood glucose levels after a meal, but it can take up to a month to see decreases in fasting blood glucose. Nateglinide is only effective at intermediate glucose levels (3-10 mmol/L) and won't work if your glucose levels are too high (over 15 mmol/L). It is also selective for pancreatic beta cells and does not affect other parts of
When to interrupt dosage
The measure of Nateglinide is contingent upon the diagnosed malady. The amount of dosage can be found in the table shown below, depending on the technique of delivery (e.g. Tablet, film coated - Oral or Tablet).Condition
Dosage
Administration
Type 2 Diabetes
, 60.0 mg, 120.0 mg, 180.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Nateglinide has two limitations. Using it is not recommended for the conditions enumerated in the following table.Nateglinide ContraindicationsCondition
Risk Level
Notes
Diabetic Ketoacidosis
Do Not Combine
Type 1 Diabetes
Do Not Combine
Common Nateglinide Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Nateglinide.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Nateglinide.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Nateglinide.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Nateglinide.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Nateglinide.
Nateglinide Toxicity & Overdose RiskTaking too much of this medication can lead to low blood sugar levels, resulting in symptoms such as dizziness, confusion, sweating, and hunger.
Nateglinide Novel Uses: Which Conditions Have a Clinical Trial Featuring Nateglinide?
162 active studies are currently investigating the efficacy of Nateglinide in managing Type 2 Diabetes.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
193 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Nateglinide Reviews: What are patients saying about Nateglinide?
5Patient Review
8/19/2011 I had to stop taking this in 2004 because it caused my blood sugar levels to drop too low. However, it's the only oral diabetic drug that I can take without having bad reactions (I'm part of the 1%). So far, since starting back on it in March, I haven't had any problems.
5Patient Review
11/4/20094Patient Review
9/10/2012 I switched to this pill from Actos at my doctor's suggestion, and I'm really happy with it. My readings are better than they were on Actos, and it's cheaper too!
3.7Patient Review
3/23/2012 I unfortunately had to discontinue this medication after only thirteen days due to the extreme constipation it caused me. I was taking laxatives two times a day just to be able to go!
3.3Patient Review
2/21/2013 I've been taking it for about 6 months and it tends to bring my blood sugar down too much. I also take metoformin with it. I have to watch my sugar every 2 hours to be sure I havent dropped too low after a meal.
3.3Patient Review
9/29/20093Patient Review
12/15/2009 I'm still seeing high glucose readings after meals, even though I take Janumet twice daily and try to eat a low-glycemic diet.
2.3Patient Review
1/8/2012 This item did not lower my readings as anticipated. My readings remained constantly above 250.
1.7Patient Review
5/30/2011 Despite taking this medication and following a healthy diet, my post-meal blood sugar levels are still too high.
1.3Patient Review
3/27/2010 This drug has been working well for me. I take Starlix (Nateglinide), Januvia, and Metformin.
1.3Patient Review
3/31/2011 The taste of this drug is really bad and lingers for a while.
Patient Q&A Section about nateglinide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When should nateglinide be given?
"It is important to take nateglinide exactly as your doctor tells you to. The usual dose is one tablet three times daily, before your main meals (usually breakfast, lunch and dinner), taken either immediately before or up to 30 minutes before a meal."
Answered by AI
What class is nateglinide?
"Nateglinide is a meglitinide, a class of drug that helps the body regulate the amount of glucose in the blood. It does this by stimulating the pancreas to release insulin, decreasing the amount of glucose in the blood."
Answered by AI
Is nateglinide the same as metformin?
"The study showed that nateglinide and metformin monotherapy can both improve glycemic control, although they do so in different ways. Nateglinide decreases the fluctuations in blood sugar levels that occur after meals, while metformin primarily affects fasting blood sugar levels."
Answered by AI
What is the medication nateglinide used for?
"Nateglinide is used to help control blood sugar levels in patients with type 2 diabetes, when combined with diet and exercise. It works by causing your pancreas to release more insulin into the blood stream. Patients who have insulin-dependent or type 1 diabetes will not see any benefits from this medicine."
Answered by AI