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Advanced MRI Techniques for Cardiovascular Disease

N/A

Recruiting

Led By Marcus Y Chen, M.D.

Research Sponsored by National Heart, Lung, and Blood Institute (NHLBI)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Subjects with known or suspected cardiovascular disease

Age greater than or equal to 7 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up on going

Awards & highlights

Study Summary

This trial is testing new ways of imaging the heart and other organs using MRI. It will also look at the relationship between cardiovascular disease and other organ systems.

Who is the study for?

This trial is for people aged 7 and older, both healthy individuals and those with known or suspected cardiovascular disease. Participants must be able to lie still in an MRI scanner, follow instructions, provide informed consent (or have a guardian do so), and commit to the study procedures. Those previously exposed to gadolinium-based contrast agents or needing heart MRIs may also be of particular interest.Check my eligibility

What is being tested?

The trial aims to develop new MRI methods for imaging the heart and other organs, describe cardiovascular diseases using these methods, examine the link between cardiovascular disease and risk factors affecting other organs, and detect any long-term brain deposits of gadolinium from previous MRIs. It involves up to 2-hour scans with potential monitoring of vital signs.See study design

What are the potential side effects?

MRI is generally safe but can cause discomfort due to loud noises during scanning or claustrophobia inside the tube-like scanner. The contrast agent used may lead to allergic reactions in rare cases; however, participants will be screened for safety regarding this aspect.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have a known or suspected heart condition.

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I am 7 years old or older.

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I do not have any known heart diseases.

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I have a known or suspected serious illness besides heart disease.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ on going

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~on going

This trial's timeline: 3 weeks for screening, Varies for treatment, and on going for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Assesment of Gad deposition in the brain

Evaluating the correlation

Technical development of MRI sequences

+1 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: 1Experimental Treatment1 Intervention

MRI

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

MRI

2009

Completed Phase 2

~1370

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH

2,784 Previous Clinical Trials

2,684,275 Total Patients Enrolled

National Heart, Lung, and Blood Institute (NHLBI)Lead Sponsor

3,836 Previous Clinical Trials

47,846,048 Total Patients Enrolled

Marcus Y Chen, M.D.Principal InvestigatorNational Heart, Lung, and Blood Institute (NHLBI)

6 Previous Clinical Trials

6,412 Total Patients Enrolled

Media Library

Cardiovascular Magnetic Resonance (CMR) Imaging Clinical Trial Eligibility Overview. Trial Name: NCT03581318 — N/A

Cardiovascular Physiology Research Study Groups: 1

Cardiovascular Physiology Clinical Trial 2023: Cardiovascular Magnetic Resonance (CMR) Imaging Highlights & Side Effects. Trial Name: NCT03581318 — N/A

Cardiovascular Magnetic Resonance (CMR) Imaging 2023 Treatment Timeline for Medical Study. Trial Name: NCT03581318 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this clinical trial accept participants of legal age?

"To be eligible for participation, patients must fall within the 7-99 year old age bracket. For those under 18 and over 65 additional studies are available."

Answered by AI

Is enrollment in this investigation still attainable?

"Affirmative. The clinicaltrials.gov portal states that the trial is in a recruitment phase, having been initially posted on July 12th 2018 and last modified on November 18th 2022. A total of 5000 participants are needed from one site to complete this research project."

Answered by AI

What are the criteria for individuals to be considered qualified participants in this clinical study?

"This research project seeks to include 5000 individuals with a cardiovascular profile ranging from 7 to 99 years old. To be considered, potential participants need to fulfill the expectations of: being at least seven years old, able and willing to follow instructions while stationary in an MRI machine, free of any existing known heart condition, have tbe capacity for giving informed consent or guardian agreement if necessary; plus display cooperation towards all study steps and make themselves available during scheduled events."

Answered by AI

How many participants have the capacity to join this trial?

"Yes, according to the information found on clinicialtrials.gov, this research initiative is presently in search of participants. The trial was inaugurated on July 12th 2018 and underwent a change as recently as November 18th 2022. In total, 5000 individuals must be recruited from one medical site."

Answered by AI

Recent research and studies

Journal of Cardiovascular Magnetic ResonanceJournal

A Comparison of Cine CMR Imaging at 0.55 T and 1.5 T

Bandettini, W. Patricia, Sujata M. Shanbhag, Christine Mancini, Delaney R. McGuirt, Peter Kellman, Hui Xue, Jennifer L. Henry, et al.. 2020. “A Comparison of Cine CMR Imaging at 0.55 T and 1.5 T”. Journal of Cardiovascular Magnetic Resonance. Springer Science and Business Media LLC. doi:10.1186/s12968-020-00618-y.

JACC: Cardiovascular ImagingJournal

Evaluation of Myocardial Infarction by Cardiovascular Magnetic Resonance at 0.55-T Compared to 1.5-T

Bandettini, W. Patricia, Sujata M. Shanbhag, Christine Mancini, Jennifer L. Henry, Margaret Lowery, Marcus Y. Chen, Hui Xue, Peter Kellman, and Adrienne E. Campbell-Washburn. 2021. “Evaluation of Myocardial Infarction by Cardiovascular Magnetic Resonance at 0.55-T Compared to 1.5-T”. JACC: Cardiovascular Imaging. Elsevier BV. doi:10.1016/j.jcmg.2021.02.024.

clinicaltrials.govStudy

Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging

2018. "Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03581318.

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