Lovenox

Acute Chest Syndrome, Deep Vein Thrombosis, Outpatients + 7 more
Treatment
6 FDA approvals
20 Active Studies for Lovenox

What is Lovenox

EnoxaparinThe Generic name of this drug
Treatment SummaryEnoxaparin is a medication used to reduce the risk of blood clots in patients with certain thromboembolic disorders. It was approved by the FDA in 1993 and is available in both injection and pill form. Enoxaparin is more effective at preventing the formation of blood clots than unfractionated heparin, with no increased risk of serious bleeding.
Lovenoxis the brand name
image of different drug pills on a surface
Lovenox Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lovenox
Enoxaparin
1993
183

Approved as Treatment by the FDA

Enoxaparin, also known as Lovenox, is approved by the FDA for 6 uses like Inpatients and Immobility .
Inpatients
Immobility
General Surgery
Deep Vein Thrombosis
Acute Chest Syndrome
Helps manage Acute Coronary Syndrome (ACS)
Outpatients

Effectiveness

How Lovenox Affects PatientsEnoxaparin is used to prevent and reduce the risk of thromboembolic complications such as deep vein thrombosis (DVT), pulmonary embolism, and ischemic cardiac complications. When taken as a subcutaneous injection, it works quickly and has been shown to be more effective than heparin at preventing these complications. However, it also increases the risk of bleeding and low blood platelet count, and pregnant women with prosthetic mechanical heart valves should take caution as they are at a higher risk of thromboembolism.
How Lovenox works in the bodyEnoxaparin helps stop blood clots from forming by binding to a protein in the blood, antithrombin III. This forms a complex that blocks the actions of a clotting factor, factor Xa, so it can't form clots. Enoxaparin also directly blocks another clotting factor, thrombin, but not as effectively as another drug, unfractionated heparin. In this way, it can prevent the formation of a clot and any related thromboembolic events.

When to interrupt dosage

The proposed measure of Lovenox is contingent upon the diagnosed condition, including Deep Vein Thrombosis, Immobility and Outpatients. The amount of dosage is contingent upon the technique of delivery as detailed in the table beneath.
Condition
Dosage
Administration
General Surgery
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous
Deep Vein Thrombosis
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous
Outpatients
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous
Ischemia
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous
Myocardial Infarction
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous
Inpatients
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous
Immobility
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous
Acute Chest Syndrome
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous
Angioplasty
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous
Angina, Unstable
, 400.0 mg/mL, 600.0 mg/mL, 800.0 mg/mL, 300.0 mg/mL, 100.0 mg/mL, 1200.0 mg/mL, 150.0 mg/mL, 200.0 mg/mL, 500.0 mg/mL, 900.0 mg/mL
Intravenous; Subcutaneous, , Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection - Subcutaneous, Solution - Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous

Warnings

Lovenox has six contraindications, so it should not be used with the ailments delineated in the table below.Lovenox Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Heparin Induced Thrombocytopenia (HIT)
Do Not Combine
Hemorrhage
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Low Platelet Count
Do Not Combine
There are 20 known major drug interactions with Lovenox.
Common Lovenox Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Enoxaparin.
Andexanet alfa
Major
The therapeutic efficacy of Andexanet alfa can be decreased when used in combination with Enoxaparin.
Anti-inhibitor coagulant complex
Major
The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Enoxaparin.
Antihemophilic factor (recombinant), PEGylated
Major
The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Enoxaparin.
Antihemophilic factor human
Major
The therapeutic efficacy of Antihemophilic factor human can be decreased when used in combination with Enoxaparin.
Lovenox Toxicity & Overdose RiskThe lowest toxic dose of enoxaparin in mice has been found to be greater than 5000 mg/kg when given orally and greater than 2500 mg/kg when given subcutaneously. Accidental overdose can lead to excessive bleeding, which can be reversed by injecting a 1% protamine sulfate solution intravenously. The dose of protamine sulfate should be equal to the dose of enoxaparin administered. If at least 12 hours have passed since the last dose of enoxaparin, protamine may not be necessary; however, it is important to avoid an overdose with protamine as it can be fatal.
image of a doctor in a lab doing drug, clinical research

Lovenox Novel Uses: Which Conditions Have a Clinical Trial Featuring Lovenox?

76 ongoing trials are assessing the potential of Lovenox to mitigate Immobility, Acute Chest Syndrome and Outpatient conditions.
Condition
Clinical Trials
Trial Phases
Acute Chest Syndrome
1 Actively Recruiting
Not Applicable
Immobility
0 Actively Recruiting
General Surgery
1 Actively Recruiting
Not Applicable
Deep Vein Thrombosis
17 Actively Recruiting
Phase 4, Phase 3, Not Applicable, Phase 1, Phase 2
Outpatients
1 Actively Recruiting
Not Applicable
Myocardial Infarction
0 Actively Recruiting
Ischemia
0 Actively Recruiting
Angina, Unstable
0 Actively Recruiting
Inpatients
2 Actively Recruiting
Not Applicable, Phase 2
Angioplasty
8 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 1, Phase 2

Lovenox Reviews: What are patients saying about Lovenox?

5Patient Review
6/11/2014
Lovenox for Deep Vein Thrombosis Prevention
I've developed a rash around the injection site that is really annoying because it itches. Now I'm also getting a rash on my neck. Does anyone know if this is serious?
5Patient Review
10/16/2014
Lovenox for Deep Vein Thrombosis Prevention
Make sure you grab some alcohol swabs and a sharps container when picking up your Lovenox; the YouTube video says they're included but my pharmacist never mentioned it. I was lucky enough to have rubbing alcohol at home, but others might not be so prepared. So please be mindful and get these items before beginning injections!
5Patient Review
4/5/2019
Lovenox for Deep Vein Thrombosis Prevention in Abdominal Surgery
Lovenox injections have been an easy and painless part of my post-op recovery from a hysterectomy. I've had no issues with blood clots, just the occasional loose stool.
5Patient Review
7/15/2016
Lovenox for Treatment to Prevent a Blood Clot in the Lung
If you go slowly, this injection is actually painless. I learned that the hard way, but it's much better than feeling that burning sensation.
5Patient Review
1/8/2015
Lovenox for Blood Clot in a Deep Vein
Lovenox can be painful when injected too quickly. I found that going slowly helped to alleviate this problem.
4.7Patient Review
12/1/2013
Lovenox for Blood Clots in Deep Veins and in Blood Vessel of the Lung
I was injected with this medicine around my waistline at a 45 degree angle. I was told to inject it slowly, and I did as instructed. These shots have helped me reduce the burning, bruising, and knots in my stomach. I hope I am finished with them now.
3.7Patient Review
3/24/2014
Lovenox for Blood Clot in a Deep Vein
Despite taking this medication as directed for over six months, I still ended up developing a clot in my left leg.
3.7Patient Review
12/22/2015
Lovenox for Blood Clot in a Deep Vein
I'm not a fan of needles, and this treatment leaves me bruised and with welts. I also have trouble getting the needle all the way in.
3.7Patient Review
2/20/2014
Lovenox for Blood Clot Prevention Following Percutaneous Coronary Intervention
There was a bit of initial discomfort when I received the injection, but it was well worth it for the results.
3.3Patient Review
6/23/2015
Lovenox for Blood Clots in Deep Veins and in Blood Vessel of the Lung
It has been effective for me.
3Patient Review
2/18/2022
Lovenox for Blood Clot Prevention Following Percutaneous Coronary Intervention
About an hour after my first injection, I had a reaction that made my blood pressure drop and I almost fainted.
2.7Patient Review
7/23/2014
Lovenox for Deep Vein Thrombosis Prevention
The needle is the easy part. The pain comes after it's out.
1Patient Review
4/14/2020
Lovenox for Deep Vein Thrombosis Prevention
I had a very bad reaction to this medication. I suffered a stroke that left me with permanent paralysis on my left side. Please avoid this drug if at all possible.
1Patient Review
1/28/2017
Lovenox for Deep Vein Thrombosis Prevention in Knee Replacement
Unfortunately, this didn't prevent or eliminate the DVT in my calf following knee surgery.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lovenox

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lovenox a blood thinner or anticoagulant?

"Enoxaparin is a drug that falls under the category of anticoagulants, more specifically low molecular weight heparin. This class of drugs is commonly referred to as blood thinners, although they do not actually thin the blood. Instead, they lengthen the time it takes for a blood clot to form."

Answered by AI

Does Lovenox have side effects?

"Side effects that may occur include: feeling nauseous, having diarrhea, anemia, feeling confused, or."

Answered by AI

What is Lovenox used for?

"Enoxaparin prevents and treats harmful blood clots by reducing the activity of clotting proteins in the blood, which lowers the risk of a stroke or heart attack."

Answered by AI

Is Lovenox a high risk medication?

"If used incorrectly, Lovenox can cause serious injury and complications. Giving Lovenox in too high of a dose increases the risk of bleeding and adverse effects. Lovenox should only be used with a prescription and appropriate guidance from a healthcare provider."

Answered by AI

Clinical Trials for Lovenox

Have you considered Lovenox clinical trials? We made a collection of clinical trials featuring Lovenox, we think they might fit your search criteria.
Have you considered Lovenox clinical trials? We made a collection of clinical trials featuring Lovenox, we think they might fit your search criteria.
Have you considered Lovenox clinical trials? We made a collection of clinical trials featuring Lovenox, we think they might fit your search criteria.
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