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What is Lotensin
BenazeprilThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a commonly prescribed diuretic that helps reduce fluid retention and is used to treat edema and high blood pressure. While it is still used as a treatment, it has been declining in popularity due to the rise of other drugs like angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs). Some drugs available on the market combine hydrochlorothiazide with ACEIs or ARBs. Hydrochlorothiazide was FDA approved in 1959.
Lotensinis the brand name
Lotensin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lotensin
Benazepril
1991
594
Approved as Treatment by the FDA
Benazepril, otherwise called Lotensin, is approved by the FDA for 2 uses which include previously treated and Hypertensive disease .previously treated
In adults whose disease has relapsed with Hydrochlorothiazide
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Amlodipine
Effectiveness
How Lotensin Affects PatientsHydrochlorothiazide is designed to help the body get rid of excess water in the urine. The amount taken can vary from person to person and usually ranges from 25-100mg. People with reduced kidney or liver function should be especially cautious when taking this drug.
How Lotensin works in the bodyHydrochlorothiazide works by blocking a specific transporter in the distal convoluted tubule. This transporter normally pumps sodium from the tubule into the epithelial cells, creating a concentration gradient that encourages the reabsorption of water. By blocking this transporter, hydrochlorothiazide reduces the amount of water reabsorbed and causes more to be excreted in the urine.
When to interrupt dosage
The measure of Lotensin is contingent upon the diagnosed circumstances, such as Antepartum magnesium sulfate prophylaxis, blood pressure inadequately regulated with monotherapy and antihypertensives. The dosage can be found in the table below, based on the administration system (e.g. Tablet, coated - Oral or Oral).Condition
Dosage
Administration
Diabetic Nephropathy
20.0 mg, , 5.0 mg, 10.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral
Kidney Diseases
20.0 mg, , 5.0 mg, 10.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral
previously treated
20.0 mg, , 5.0 mg, 10.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral
Congestive Heart Failure
20.0 mg, , 5.0 mg, 10.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral
Hypertensive disease
20.0 mg, , 5.0 mg, 10.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral
Warnings
Lotensin ContraindicationsCondition
Risk Level
Notes
Angioedema
Do Not Combine
Pulse Frequency
Do Not Combine
Common Lotensin Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Benazepril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Benazepril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Benazepril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Benazepril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Benazepril.
Lotensin Toxicity & Overdose RiskThe amount of hydrochlorothiazide that is toxic to mice and rats is more than 10g/kg. Those who overdose may experience low levels of potassium, chloride, and sodium in the blood and require fluids and electrolytes. In more severe cases, medications to raise blood pressure and oxygen therapy may also be administered.
Lotensin Novel Uses: Which Conditions Have a Clinical Trial Featuring Lotensin?
158 active studies are in progress to analyze the potential of Lotensin in relieving Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Kidney Diseases
3 Actively Recruiting
Phase 2, Phase 3
previously treated
0 Actively Recruiting
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Lotensin Reviews: What are patients saying about Lotensin?
5Patient Review
3/6/2012 I'm wondering if this medication caused me to itch a lot.
5Patient Review
7/13/2009 I didn't much enjoy the dry, hacking cough this drug gave me. It left me feeling exhausted and my heart felt like it was pounding in my head, which was quite unpleasant. I stuck it out for about four months though.
5Patient Review
8/16/2010 This treatment really helped me. I'm grateful for modern medicine.
5Patient Review
5/1/2014 I've been taking this medicine for a decade now and it's never given me any issues.
4.7Patient Review
8/15/20084Patient Review
3/1/2010 I experienced some side effects while taking this medication, but they were manageable and the benefits outweighed them.
3Patient Review
3/16/2010 It's tough to say how much this medication helped because I also changed my lifestyle in other ways that could have impacted my blood pressure.
3Patient Review
5/20/20092.3Patient Review
2/17/2010 This medication didn't help me much. I'm still struggling to breathe, and I cough all the time. Plus, I have no energy and don't feel good most of the time.
2.3Patient Review
3/26/20082Patient Review
9/22/20072Patient Review
12/31/20082Patient Review
4/20/20091Patient Review
7/12/2009Patient Q&A Section about lotensin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Lotensin the same as lisinopril?
"Lotensin (benazepril) and Zestril (lisinopril) are both effective blood pressure medications that also help to protect kidney function. They are often prescribed as a first-line treatment for high blood pressure."
Answered by AI
What are the side effects for Lotensin?
"Dizziness, cough, headache, nausea, vomiting, constipation, and drowsiness are all common symptoms of vertigo."
Answered by AI
Is Lotensin a good blood pressure medicine?
"Benazepril is a common first-choice blood pressure medication due to its ability to protect kidney function, which is especially beneficial for those with diabetes or mild-to-moderate kidney disease. Additionally, benazepril lowers the risk of heart attack and stroke in people with high blood pressure, making it a well-rounded choice for blood pressure treatment."
Answered by AI
What is the drug Lotensin used for?
"This medication is a combination of two drugs, an ACE inhibitor (benazepril) and a diuretic (hydrochlorothiazide). It is used to treat high blood pressure (hypertension) by reducing the amount of water in the blood, which lowers blood pressure."
Answered by AI