What is Lotensin
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a commonly prescribed diuretic that helps reduce fluid retention and is used to treat edema and high blood pressure. While it is still used as a treatment, it has been declining in popularity due to the rise of other drugs like angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs). Some drugs available on the market combine hydrochlorothiazide with ACEIs or ARBs. Hydrochlorothiazide was FDA approved in 1959.
Esidrixis the brand name
Lotensin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Stroke and Edema .Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
Edema
Helps manage Premenstrual tension with edema
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Bedrest
Used to treat Bedrest in combination with Spironolactone
Effectiveness
How Lotensin Affects PatientsHydrochlorothiazide is designed to help the body get rid of excess water in the urine. The amount taken can vary from person to person and usually ranges from 25-100mg. People with reduced kidney or liver function should be especially cautious when taking this drug.
How Lotensin works in the bodyHydrochlorothiazide works by blocking a specific transporter in the distal convoluted tubule. This transporter normally pumps sodium from the tubule into the epithelial cells, creating a concentration gradient that encourages the reabsorption of water. By blocking this transporter, hydrochlorothiazide reduces the amount of water reabsorbed and causes more to be excreted in the urine.
When to interrupt dosage
The measure of Lotensin is contingent upon the diagnosed circumstances, such as Antepartum magnesium sulfate prophylaxis, blood pressure inadequately regulated with monotherapy and antihypertensives. The dosage can be found in the table below, based on the administration system (e.g. Tablet, coated - Oral or Oral).Condition
Dosage
Administration
calcium channel blockers
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Therapeutic procedure
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Nephrolithiasis
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Hypertensive disease
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Swollen feet or ankles
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Hypertensive disease
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Bedrest
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
prophylaxis of calcium nephrolithiasis
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Antepartum magnesium sulfate prophylaxis
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Edema
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
hypokalemia with solo treatment
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Diuretics
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
inadequate response to other therapeutic measures
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
blood pressure inadequately controlled with monotherapy
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Therapeutic procedure
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Ascites
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
inadequate control of blood pressure with monotherapy
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
antihypertensives
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Diabetes Insipidus
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Nephrotic Syndrome
25.0 mg, , 12.5 mg, 50.0 mg, 15.0 mg, 6.25 mg, 2.5 mg/mg, 5.0 mg/mg, 100.0 mg, 0.125 mg, 0.25 mg, 30.0 mg, 0.0125 mg
Tablet, coated - Oral, Oral, , Tablet, Tablet - Oral, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Tablet, film coated, Capsule, Tablet, coated, Capsule - Oral, Capsule, gelatin coated
Warnings
Lotensin ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Anuria
Do Not Combine
Common Lotensin Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Lotensin Toxicity & Overdose RiskThe amount of hydrochlorothiazide that is toxic to mice and rats is more than 10g/kg. Those who overdose may experience low levels of potassium, chloride, and sodium in the blood and require fluids and electrolytes. In more severe cases, medications to raise blood pressure and oxygen therapy may also be administered.
Lotensin Novel Uses: Which Conditions Have a Clinical Trial Featuring Lotensin?
158 active studies are in progress to analyze the potential of Lotensin in relieving Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Stroke
14 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cirrhosis
59 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Swollen feet or ankles
45 Actively Recruiting
Phase 1, Phase 2, Phase 4, Not Applicable, Early Phase 1, Phase 3
Nephrotic Syndrome
13 Actively Recruiting
Phase 2, Not Applicable, Phase 3
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
antihypertensives
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Ascites
12 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1
Hypertensive disease
22 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4
Antepartum magnesium sulfate prophylaxis
13 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Early Phase 1
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
Hypertensive disease
3 Actively Recruiting
Phase 1, Not Applicable
Left Ventricular Hypertrophy
3 Actively Recruiting
Not Applicable, Phase 4
restriction of fluid and sodium
0 Actively Recruiting
Congestive Heart Failure
24 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Diabetes Insipidus
2 Actively Recruiting
Phase 1, Phase 2
Edema
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Lotensin Reviews: What are patients saying about Lotensin?
5Patient Review
3/6/2012 I'm wondering if this medication caused me to itch a lot.
5Patient Review
7/13/2009 I didn't much enjoy the dry, hacking cough this drug gave me. It left me feeling exhausted and my heart felt like it was pounding in my head, which was quite unpleasant. I stuck it out for about four months though.
5Patient Review
8/16/2010 This treatment really helped me. I'm grateful for modern medicine.
5Patient Review
5/1/2014 I've been taking this medicine for a decade now and it's never given me any issues.
4.7Patient Review
8/15/20084Patient Review
3/1/2010 I experienced some side effects while taking this medication, but they were manageable and the benefits outweighed them.
3Patient Review
3/16/2010 It's tough to say how much this medication helped because I also changed my lifestyle in other ways that could have impacted my blood pressure.
3Patient Review
5/20/20092.3Patient Review
2/17/2010 This medication didn't help me much. I'm still struggling to breathe, and I cough all the time. Plus, I have no energy and don't feel good most of the time.
2.3Patient Review
3/26/20082Patient Review
9/22/20072Patient Review
12/31/20082Patient Review
4/20/20091Patient Review
7/12/2009Patient Q&A Section about lotensin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Lotensin the same as lisinopril?
"Lotensin (benazepril) and Zestril (lisinopril) are both effective blood pressure medications that also help to protect kidney function. They are often prescribed as a first-line treatment for high blood pressure."
Answered by AI
What are the side effects for Lotensin?
"Dizziness, cough, headache, nausea, vomiting, constipation, and drowsiness are all common symptoms of vertigo."
Answered by AI
Is Lotensin a good blood pressure medicine?
"Benazepril is a common first-choice blood pressure medication due to its ability to protect kidney function, which is especially beneficial for those with diabetes or mild-to-moderate kidney disease. Additionally, benazepril lowers the risk of heart attack and stroke in people with high blood pressure, making it a well-rounded choice for blood pressure treatment."
Answered by AI
What is the drug Lotensin used for?
"This medication is a combination of two drugs, an ACE inhibitor (benazepril) and a diuretic (hydrochlorothiazide). It is used to treat high blood pressure (hypertension) by reducing the amount of water in the blood, which lowers blood pressure."
Answered by AI