Tranexamic acid tablets for Lichen Planus Pigmentosus

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Lichen Planus Pigmentosus+2 MoreTranexamic acid tablets - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial seeks to determine whether tranexamic acid can reduce pigmentation in patients with LPP and EDP.

Eligible Conditions
  • Lichen Planus Pigmentosus
  • Fitzpatrick's Skin Type IV
  • Ashy Dermatosis of Ramirez

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 2 Secondary · Reporting Duration: 11 visits over 270 days

Day 270
Change in Erythema using Colorimetry
Change in Erythema using Diffuse Reflectance Spectroscopy
Change in Pigmentation using Colorimetry
Change in Pigmentation using Diffuse Reflectance Spectroscopy

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Side Effects for

3900 mg/Day
59%Headache
37%Nasal & Sinus Symptoms
24%Back Pain
20%Abdominal Pain
11%Musculoskeletal Pain
10%Anemia
9%Arthralgia
8%Muscle Cramps & Spasms
7%Fatigue
6%Migraine
1%Tachycardia
1%Decreased Blood Sugar
This histogram enumerates side effects from a completed 2008 Phase 3 trial (NCT00386308) in the 3900 mg/Day ARM group. Side effects include: Headache with 59%, Nasal & Sinus Symptoms with 37%, Back Pain with 24%, Abdominal Pain with 20%, Musculoskeletal Pain with 11%.

Trial Design

1 Treatment Group

Treatment
1 of 1

Experimental Treatment

5 Total Participants · 1 Treatment Group

Primary Treatment: Tranexamic acid tablets · No Placebo Group · Phase 2

Treatment
Drug
Experimental Group · 1 Intervention: Tranexamic acid tablets · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tranexamic acid
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 11 visits over 270 days

Who is running the clinical trial?

Henry Ford Health SystemLead Sponsor
265 Previous Clinical Trials
2,014,437 Total Patients Enrolled
Henry W Lim, MDPrincipal InvestigatorHenry Ford HS

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

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References