Kaletra

Chronic hepatitis C genotype 1a, Chronic hepatitis C genotype 1b, HIV + 3 more
Treatment
1 FDA approval
20 Active Studies for Kaletra

What is Kaletra

RitonavirThe Generic name of this drug
Treatment SummaryRitonavir is a medication used to treat HIV by blocking the virus from reproducing. It is usually given in combination with other protease inhibitors, such as Technivie, Holkira Pak, and Viekira Pak. It is also used to treat chronic hepatitis C genotypes 1a and 1b, either with or without cirrhosis, in combination with Ribavirin. Ritonavir can increase the effectiveness of other protease inhibitors and should not be used in combination with HIV-1 protease inhibitor treatments as it can lead to drug resistance.
Kaletrais the brand name
Kaletra Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kaletra
Ritonavir
2000
50

Approved as Treatment by the FDA

Ritonavir, also called Kaletra, is approved by the FDA for 1 uses which include HIV .
HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with null

Effectiveness

How Kaletra Affects PatientsRitonavir is a medication used to treat HIV-1. It works by blocking a part of HIV called protease, which is necessary for HIV to spread and cause infection. Ritonavir stops the spread of HIV by preventing the formation of infectious viral particles. It is usually taken in combination with other anti-HIV drugs and requires a low dose of ritonavir to increase its effectiveness.
How Kaletra works in the bodyRitonavir is used to fight HIV by blocking the enzyme that cuts up proteins needed by the virus to replicate. It also blocks the cytochrome P450 enzyme in the intestines and liver, which helps prevent other protease inhibitors from being transported or released from cells. This makes it harder for HIV to spread.

When to interrupt dosage

The proposed measure of Kaletra is contingent upon the diagnosed condition, including weight 40 kg or more, HIV (Human Immunodeficiency Virus) and Mild to Moderate COVID-19. The dosage shifts, based on the delivery procedure (e.g. Oral or Tablet, film coated - Oral) featured in the following table.
Condition
Dosage
Administration
weight 40 kg or more
, 50.0 mg, 20.0 mg/mL, 25.0 mg, 80.0 mg/mL, 100.0 mg, 33.3 mg, 33.33 mg, 100.0 mg/mL
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
SARS-CoV-2 Positive Patients
, 50.0 mg, 20.0 mg/mL, 25.0 mg, 80.0 mg/mL, 100.0 mg, 33.3 mg, 33.33 mg, 100.0 mg/mL
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
HIV
, 50.0 mg, 20.0 mg/mL, 25.0 mg, 80.0 mg/mL, 100.0 mg, 33.3 mg, 33.33 mg, 100.0 mg/mL
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
Mild to Moderate COVID-19
, 50.0 mg, 20.0 mg/mL, 25.0 mg, 80.0 mg/mL, 100.0 mg, 33.3 mg, 33.33 mg, 100.0 mg/mL
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
Chronic hepatitis C genotype 1a
, 50.0 mg, 20.0 mg/mL, 25.0 mg, 80.0 mg/mL, 100.0 mg, 33.3 mg, 33.33 mg, 100.0 mg/mL
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
Chronic hepatitis C genotype 1b
, 50.0 mg, 20.0 mg/mL, 25.0 mg, 80.0 mg/mL, 100.0 mg, 33.3 mg, 33.33 mg, 100.0 mg/mL
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release

Warnings

Kaletra has twenty-five contraindications, so it should not be taken while battling the conditions mentioned in the following table.Kaletra Contraindications
Condition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Pulmonary Arterial Hypertension
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
There are 20 known major drug interactions with Kaletra.
Common Kaletra Drug Interactions
Drug Name
Risk Level
Description
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Ritonavir.
Alfuzosin
Major
The serum concentration of Alfuzosin can be increased when it is combined with Ritonavir.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ritonavir.
Amodiaquine
Major
The metabolism of Amodiaquine can be decreased when combined with Ritonavir.
Anagrelide
Major
The metabolism of Anagrelide can be increased when combined with Ritonavir.
Kaletra Toxicity & Overdose RiskThere is little known about the effects of ritonavir overdose in humans, though one patient experienced tingling sensations after taking 1500 mg per day for two days. One post-marketing case has been reported of kidney failure and an allergy-like reaction. Rat tests suggest that it would take more than 2500 mg/kg to be lethal, and that other side effects could include liver damage, inflammation of the pancreas, or an allergic reaction.

Kaletra Novel Uses: Which Conditions Have a Clinical Trial Featuring Kaletra?

43 active trials are currently being conducted to assess the potential of Kaletra in alleviating Chronic hepatitis C genotype 1a, weight 40 kg or more and HIV (Human Immunodeficiency Virus) symptoms.
Condition
Clinical Trials
Trial Phases
HIV
50 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
weight 40 kg or more
0 Actively Recruiting
Chronic hepatitis C genotype 1a
0 Actively Recruiting
Mild to Moderate COVID-19
0 Actively Recruiting
Chronic hepatitis C genotype 1b
0 Actively Recruiting
SARS-CoV-2 Positive Patients
0 Actively Recruiting

Kaletra Reviews: What are patients saying about Kaletra?

5Patient Review
4/14/2008
Kaletra for HIV
While I don't know for certain if Kaletra played a role, I now have necrosis in both of my hips. Additionally, it has made me gain weight and makes losing weight much more difficult.
5Patient Review
9/20/2010
Kaletra for HIV
Anesthesia can have a variety of potential side effects, including nausea, vomiting, dizziness, and drowsiness. More serious risks include heart problems, breathing difficulties, and allergic reactions. Be sure to discuss all the possible risks and benefits of anesthesia with your doctor before having any procedure done.
5Patient Review
2/21/2009
Kaletra for HIV
I was on Kaletra and Truvada for six years with few problems other than gastrointestinal issues. Recently, my cholesterol started to rise slowly, so my doctor switched me to Reyataz/Norvir/Truvada.
5Patient Review
12/24/2009
Kaletra for HIV
Kaletra/Combivar has been working great for me for the last 5 years. I've never had any issues and it's kept me undetectable this whole time.
5Patient Review
6/24/2014
Kaletra for Prevention of HIV Infection after Exposure
I experienced no negative side effects from this drug, which is great. It can be taken with or without food, and it seems to work best when taken with other anti-HIV medications.
4.7Patient Review
4/28/2010
Kaletra for HIV
I've been undetectable since 2000, thanks to this drug in combination with Sustiva and Viread. I used to take Combivor but had to switch because it caused muscle depletion (I can't remember the medical term for it). The other reviewer is right - the cost of this medication is outrageous. I have Medicare D insurance and the copay is through the roof.
4.7Patient Review
1/2/2016
Kaletra for HIV
I had a lot of bad side effects when I first started taking Atripla, but then my doctor put me on Kaletra and I haven't had any problems since.
4.7Patient Review
10/28/2007
Kaletra for HIV
4.3Patient Review
12/7/2007
Kaletra for HIV
I experienced some nausea when I first started taking this medication, but it quickly subsided. Additionally, this drug worked when others have failed in the past. I've been taking it for over two years now without any issues of resistance.
4.3Patient Review
5/17/2013
Kaletra for HIV
Kaletra in conjunction with Truvada seems to help control some of the gastric issues I experience. However, I wish it had more of an impact on my CD4 count.
4Patient Review
10/27/2008
Kaletra for HIV
My only issue is the expense. With everything rising, I struggle to pay my copay. Is there any assistance?
4Patient Review
12/14/2011
Kaletra for HIV
I've been taking Kaletra, Viread, and Ziagen for five years now with few problems. The biggest issue has been high cholesterol from Kaletra, but I take Pravastatin to help with that. The four pills are large but manageable. My CD4 counts have stayed undetectable and incredible for over five years without any nausea from Kaletra.
3.7Patient Review
10/23/2007
Kaletra for HIV

Patient Q&A Section about kaletra

Is there a generic for Kaletra?

"Kaletra is a combination of two medications, lopinavir and ritonavir, that is FDA approved for the treatment of HIV-1 infection in adult and pediatric patients. The generic formulations of Kaletra are being manufactured by Lannett and Camber Pharmaceuticals." - Anonymous Online Contributor

Unverified Answer

What are the side effects of Kaletra?

"The following effects may occur: diarrhea, nausea, vomiting, stomach upset, gas, headache, and trouble sleeping. If you experience any of these effects for an extended period of time, or if they worsen, tell your doctor or pharmacist. Keep in mind that your doctor prescribed this medication because they believe that the benefits of taking it outweigh the potential risks of side effects." - Anonymous Online Contributor

Unverified Answer

What is Kaletra prescribed for?

"KALETRA can decrease the amount of HIV in your blood and increase your CD4+ cell counts.

A prescription medicine, KALETRA is taken with other antiretroviral medicines to treat human immunodeficiency virus-1 (HIV-1) infection in adults and children aged 14 days or older. HIV is the virus that causes AIDS (acquired immune deficiency syndrome). KALETRA works by decreasing the amount of HIV in your blood and increasing CD4+ cell counts." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Kaletra

Have you considered Kaletra clinical trials? We made a collection of clinical trials featuring Kaletra, we think they might fit your search criteria.
Have you considered Kaletra clinical trials? We made a collection of clinical trials featuring Kaletra, we think they might fit your search criteria.
Have you considered Kaletra clinical trials? We made a collection of clinical trials featuring Kaletra, we think they might fit your search criteria.
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