What is Glyxambi
LinagliptinThe Generic name of this drug
Treatment SummaryLinagliptin is a type of medication used to treat type 2 diabetes. It is unique from other diabetes medications in that it is not eliminated by the kidneys and its effects depend on the concentration of the drug in the body. It was approved by the FDA in 2011 and is manufactured by Boehringer Ingelheim.
Tradjentais the brand name
Glyxambi Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tradjenta
Linagliptin
2011
17
Approved as Treatment by the FDA
Linagliptin, also known as Tradjenta, is approved by the FDA for 3 uses like Physical Activity and Diet .Physical Activity
Used to treat Exercise in combination with Empagliflozin
Diet
Used to treat Diet in combination with Empagliflozin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Empagliflozin
Effectiveness
How Glyxambi Affects PatientsTaking 5mg of linagliptin stops the DPP-4 enzyme from working for up to 24 hours. As a result, the GLP-1 hormone increases, which helps the body better control blood sugar levels. This can be seen by lower levels of glucose and hemoglobin in the blood.
How Glyxambi works in the bodyLinagliptin works by blocking an enzyme called DPP-4. This stops the breakdown of two hormones: GLP-1 and glucose-dependant insulinotropic polypeptide (GIP). These hormones then stimulate the pancreas to release insulin while decreasing the release of glucagon. This leads to the liver not breaking down as much glycogen and more insulin to be released when blood sugar is high.
When to interrupt dosage
The recommended measure of Glyxambi is contingent upon the diagnosed disorder, including Physical Activity, Diet and Type 2 Diabetes. The dose likewise fluctuates as per the technique of delivery (e.g. Tablet - Oral or Tablet) mentioned in the table beneath.Condition
Dosage
Administration
Physical Activity
, 5.0 mg, 2.5 mg
Tablet - Oral, Tablet, Oral, , Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, film coated, extended release
Diet
, 5.0 mg, 2.5 mg
Tablet - Oral, Tablet, Oral, , Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, film coated, extended release
Type 2 Diabetes
, 5.0 mg, 2.5 mg
Tablet - Oral, Tablet, Oral, , Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, film coated, extended release
Warnings
Glyxambi ContraindicationsCondition
Risk Level
Notes
Kidney Failure
Do Not Combine
Metabolic acidosis
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Dialysis therapy
Do Not Combine
Acute Coryza
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Linagliptin may interact with Toxoplasma Infections
Common Glyxambi Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Linagliptin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Linagliptin.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Linagliptin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Linagliptin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Linagliptin.
Glyxambi Toxicity & Overdose RiskThe recommended dosage of linagliptin does not change based on factors such as race, age, weight, sex, kidney health, or liver health. Clinical trials indicate that linagliptin is safe for people aged 10 to 18, but no studies have been done on younger children. Animal studies showed that female rats had an increased risk of lymphoma when taking a dose 200 times greater than the recommended amount. Other than this, linagliptin has not been shown to cause mutations, chromosome changes, or fertility problems.
Glyxambi Novel Uses: Which Conditions Have a Clinical Trial Featuring Glyxambi?
196 active trials are being conducted to assess the utility of Glyxambi in providing Physical Activity, Type 2 Diabetes and Diet management.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
176 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Early Phase 1, Phase 1, Phase 3
Physical Activity
37 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Diet
4 Actively Recruiting
Not Applicable
Glyxambi Reviews: What are patients saying about Glyxambi?
5Patient Review
2/4/2016 This weight loss treatment is very effective. I'm seeing great results, about 10 pounds lost per month.
5Patient Review
8/10/2015 I've been taking this medication since I was diagnosed with diabetes, and it's been really helpful in managing my blood sugar levels.
5Patient Review
10/26/2016 This medication is incredible! I've tried so many different diabetes medications and nothing has worked as well as this one. My readings have improved dramatically, and I couldn't be happier.
5Patient Review
6/6/2017 I've dropped 24lbs in just over 17 weeks and I feel great! My blood sugar is finally under control and I've even started working out and watching what I eat.
5Patient Review
9/7/2018 Glyxambi has been a great help to me. Not only have I lost sixty pounds since September 2015, but my a1c level has stayed at 6.1.
5Patient Review
12/26/2019 I much prefer this medication to Janumet 50/1000 mg
5Patient Review
5/12/2016 My A1C levels dropped from 11 to 7 in just three months, and I've been taking it for six with no negative side effects that I can see.
5Patient Review
3/24/2017 This medication has done wonders for me. I only had mild fatigue for the first few days, and since then I haven't experienced any negative side effects. Staying hydrated throughout the day is key while taking this medication.
5Patient Review
7/30/20154.3Patient Review
6/21/20153.3Patient Review
7/15/2016 Glyxambi lessened my A1c levels, but the joint pain and general achiness it caused was really not worth it. I'm going to have to tell my doctor that this isn't working out.
1.3Patient Review
5/7/2016 I had a lot of negative side effects from this medication, and it ultimately did not help me control my blood sugar levels. I was on it for approximately half a year.
1Patient Review
2/14/2018 Glyxambia was WAY too much for me. I felt insanely jittery and agitated after only one dose, which is not how I like to feel ever let alone first thing in the morning.
1Patient Review
4/9/2017 I had to stop taking this after only two days because I felt so sick. Nausea, vomiting, and fatigue made it impossible for me to function normally. Really disappointed.
Patient Q&A Section about glyxambi
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Glyxambi used for?
"This medication is a combination of 2 drugs, empagliflozin and linagliptin, which are used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems."
Answered by AI
What is the side effects of Glyxambi?
"The text lists a number of mild health problems that could include joint pain, nausea, increased thirst, a mild genital infection, a mild urinary tract infection, more frequent urination, a cold, or a sinus infection."
Answered by AI
Is Glyxambi metformin?
"Glyxambi (empaglifozin / linagliptin) is not a form of insulin, but rather a medication containing a combination of empagliflozin and linagliptin. These components work together to lower blood sugar levels and better regulate the insulin levels produced by your body after meals."
Answered by AI
Is Glyxambi good for diabetes?
"Empagliflozin (JARDIANCE) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor indicated to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease.
Glyxambi can help improve blood sugar in adults with type 2 diabetes when used with diet and exercise, and can help reduce the risk of cardiovascular death in adults with type 2 diabetes who have known cardiovascular disease when empagliflozin is needed. Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that's indicated to help reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease."
Answered by AI