CASE for Return to Sport

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Baylor Scott and White Sports Therapy and Research, Frisco, TX
Return to Sport
CASE - Other
Eligibility
< 65
All Sexes
What conditions do you have?
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Study Summary

This study is evaluating whether the CASE is a useful tool for evaluating athletes with concussion.

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Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether CASE will improve 8 primary outcomes and 1 secondary outcome in patients with Return to Sport. Measurement will happen over the course of through study completion, an average of 1.5 hours.

Hour 5
Blood pressure (mmHg)
Heart rate (bpm)
Heart rate reserve (peak-rest), beats/min-1
Modified Post-Concussion Symptom Scale (PCSS) (0-6)
Oxygen Saturation (%)
Rate of Perceived Exertion (Borg 6-20)
Relative peak VO2, mL·kg-1·min-1
Self-rated dyspnea (Modified Borg 0-10)
Self-rated lightheadedness (0-6)

Trial Safety

Trial Design

1 Treatment Group

CASE
1 of 1
Experimental Treatment

This trial requires 125 total participants across 1 different treatment group

This trial involves a single treatment. CASE is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

CASE
Other
In this prospective study the investigators aim to quantify participants' responses to physical activity and cognitive testing. Participants will be asked to undergo cognitive testing prior to engaging in physical activity, to identify any provocation of symptoms in adolescents ranging from ages 10 to 22 years. Responses to physical activity will be measured through metabolic testing (heart rate reserve and relative VO2 max) and physiologic markers (e.g., blood pressure, heart rate, oxygen saturation, rate of perceived exertion, dyspnea). Additionally, participants will be monitored for any changes in symptoms that occur during or after physical activity as measured by the modified PCSS symptom inventory.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: through study completion, an average of 1.5 hours
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly through study completion, an average of 1.5 hours for reporting.

Who is running the study

Principal Investigator
K. C.
Kayla Covert, Principal Investigator
Baylor Research Institute

Closest Location

Baylor Scott and White Sports Therapy and Research - Frisco, TX

Eligibility Criteria

This trial is for patients born any sex aged 65 and younger. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
10-22 years of age who have participated in organized sport activities within the past 12 months

Patient Q&A Section

How many people get return to sport a year in the United States?

"In 2003, 5.5 million American adults participated in some way in physically demanding varsity sports. Despite the enormous benefits of activity in general to a person's quality of life, it remains a challenge for health professionals to identify those who should be encouraged to participate in varsity athletics." - Anonymous Online Contributor

Unverified Answer

What are common treatments for return to sport?

"Most participants with shoulder or rotator cuff tears can return to some degree of sport regardless of their functional ability to return preinjury levels, with the exception of those experiencing pain during the activity and those with postoperative shoulder instability." - Anonymous Online Contributor

Unverified Answer

Can return to sport be cured?

"Many cases of overuse injuries and overtraining are related to previous history of injury or overtraining, respectively. These injuries can be prevented and the overtraining is curable." - Anonymous Online Contributor

Unverified Answer

What is return to sport?

"For patients undergoing ACL reconstruction the rehabilitation process may be complicated by the need to return to sport safely and to a level at which no knee disability is recorded. In order to limit the possible rehabilitation complications that may result from return to sport we recommend careful consideration be given to the risks and benefits to both the knee and the patient, before a patient can return to sport following ACL reconstruction." - Anonymous Online Contributor

Unverified Answer

What causes return to sport?

"Recent findings suggests that there are risk factors for return to sport that were not identified previously, for example, age at onset of the injuries. The need for further education was emphasised with the potential risk to future professional athletes in the event of an ACL injury and the possible impact on knee joint health." - Anonymous Online Contributor

Unverified Answer

What are the signs of return to sport?

"The return to sport depends on the level of sports activity, training level, age and the severity of concussion. It can be difficult to understand this phenomenon if doctors rely on the standard physical examination and history. In addition, there is an absence of consensus for an international definition of concussion. Recent findings of this study showed that clinical signs of returning to sport is affected by the level and age of sports and the concussion severity. However, there is no consensus for the definition of concussion." - Anonymous Online Contributor

Unverified Answer

Does case improve quality of life for those with return to sport?

"Patients who had returned to an active level of functioning have an acceptable quality of life. However it would be anticipated if they had recovered from their injury or from their illness." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for return to sport?

"The impact of return to sport is significant as shown by an increase in functional status and high satisfaction of patients with return to sport. The effect of return to sport on pain seems to be modest and this should be further confirmed as return to sport may help maintain gains in functional status in patients with knee OA." - Anonymous Online Contributor

Unverified Answer

What is the latest research for return to sport?

"Recent findings of this evidence-based review suggest that a combination of strategies have the best short-term outcomes with respect to sportsmanship, return to play and physical activity following sport injury." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of case?

"There were more common side effects of case than expected; some were very common, but some were rare. These outcomes may be due to case's high prevalence of common side-effects." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in case for therapeutic use?

"A new therapeutic application is based on the fact that some muscle and muscle-derived cells and proteins, like collagen, are present in atherosclerotic plaque. These proteins are released into the circulation from atherosclerotic tissue and could be used as biomarkers for detecting the presence of plaque. We have recently demonstrated that cell-mediated release of CGRP from activated astrocytes induced significant plaque destabilization. Findings from a recent study may be used in the diagnosis of plaque stability by detecting circulating proteins, with respect to CGRP, that are released from activated astrocytes. Furthermore, CGRP released from activated astrocytes may contribute to the pathogenesis or progression of atherosclerosis or other inflammatory neurodegenerative diseases." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving case?

"This is the first published study examining the use of clinical trials for sports medicine. It shows that not only is clinical evidence relevant to sports medicine, but that evidence is used as a reference by some of these clinical trials in terms of eligibility procedures. Clinical studies are an important reference for medical providers to use when considering treatments of athletes." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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