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Visual feedback perturbation during reaching for Speech

N/A

Recruiting

Led By Ludo Max, Ph.D.

Research Sponsored by University of Washington

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Typical children: 4;0 to 6;11 [years;months] or 10;0 to 12;11 [years;months]

250-4000 Hz pure tone hearing thresholds equal to or better than 25 dB HL for children and young adults and equal to or better than 35 dB HL for older adults

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measurements will be made only from dbs implant recordings made during the test session (~1-2 hours).

Awards & highlights

Study Summary

This trial studies how hearing our own speech affects how we talk, and how this is different for people with DBS implants. Brain activity & speech recordings are used.

Who is the study for?

This trial is for American English native speakers who have normal communication and neurological function, except those with DBS implants. Adults must be 18 or older with specific hearing thresholds. Children aged between 4 to nearly 7 years old or from 10 to nearly 13 are also eligible. Participants should not be on medications affecting sensorimotor skills, unless they're part of the DBS group.Check my eligibility

What is being tested?

The study examines how auditory feedback influences speech movements in typical individuals and patients with Deep Brain Stimulation (DBS) implants by having them read aloud while their speech and brain activity are monitored. For DBS patients, tasks will be done with stimulation turned both ON and OFF.See study design

What are the potential side effects?

Since this is not a treatment study but rather an observational one focusing on speech behavior and brain function during speaking tasks, there are no direct side effects associated with the interventions being studied.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My child is either 4 to 6 years old or 10 to 12 years old.

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My hearing level falls within the required range for my age group.

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I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measurements will be made only from dbs implant recordings made during the test session (~1-2 hours).

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measurements will be made only from dbs implant recordings made during the test session (~1-2 hours).

This trial's timeline: 3 weeks for screening, Varies for treatment, and measurements will be made only from dbs implant recordings made during the test session (~1-2 hours). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Accuracy during speech syllable sequence learning

Amplitude of long-latency auditory evoked potentials (from EEG recordings) responses

Local field potentials recorded by neural implants

+3 more

Trial Design

3Treatment groups

Experimental Treatment

Group I: Visual feedback perturbation during reachingExperimental Treatment1 Intervention

The intervention consists of manipulating real-time visual feedback during upper limb reaching movements. In our lab, such feedback perturbations can be implemented with a virtual reality display system.

Group II: Deep brain stimulationExperimental Treatment1 Intervention

This intervention consists of toggling the deep brain stimulation (DBS) implant ON/OFF prior to participation in the speech auditory-motor learning tasks and speech sequence learning tasks. This intervention can be implemented by the subject themselves as all patients have a hand- held controlled that they use to switch stimulation ON/OFF.

Group III: Auditory feedback perturbation during speechExperimental Treatment1 Intervention

The intervention consists of manipulating real-time auditory feedback during speech production. In our lab, such feedback perturbations can be implemented with either a stand-alone digital vocal processor (a device commonly used by singers and the music industry) or with software-based signal processing routines (see Equipment section for details). Note that the study does not investigate the efficacy of these hardware or software methods to induce behavioral change in subjects' speech. Rather, the study addresses basic experimental questions regarding the general role of auditory feedback in the central nervous system's control of articulatory speech movements.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Institutes of Health (NIH)NIH

2,701 Previous Clinical Trials

7,506,343 Total Patients Enrolled

University of WashingtonLead Sponsor

1,741 Previous Clinical Trials

1,847,259 Total Patients Enrolled

National Institute on Deafness and Other Communication Disorders (NIDCD)NIH

330 Previous Clinical Trials

177,964 Total Patients Enrolled

11 Trials studying Speech

884 Patients Enrolled for Speech

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still opportunities to get involved with this research endeavor?

"Reports on clinicaltrials.gov show that this trial is presently recruiting potential participants. The initial listing of the study was made available to view on 1st January 2023, and has been amended most recently on 12th December 2023."

Answered by AI

How many individuals are enrolled in this research trial?

"Affirmative. According to clinicaltrials.gov, this research project is still taking on participants since it was first posted in January 1st 2023 and last updated in December 1st of the same year. 507 patients are required from a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Behavioral and Neural Characteristics of Adaptive Speech Motor Control

Ludo Max 2023. "Behavioral and Neural Characteristics of Adaptive Speech Motor Control". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06164717.

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