APX005M, mFOLFOX, and Radiation Therapy 5Gy x 5 days for Rectal Cancer

"This study is no longer looking for new patients. The trial was first posted on April 24th, 2020 and the most recent update was made on July 14th, 2022. If you are interested in other studies, there are 1081 trials recruiting patients with advance directives and 7 different trials for APX005M, mFOLFOX, and Radiation Therapy 5Gy x 5 days that are still enrolling participants."

"APX005M, mFOLFOX, and Radiation Therapy 5Gy x 5 days is currently being evaluated in Phase 2 clinical trials. While there is some evidence supporting its safety, more data needs to be collected about the efficacy of this treatment option."

"Currently, there are 7 trials in progress that are studying the combination of APX005M, mFOLFOX, and Radiation Therapy 5Gy x 5 days. The first clinical trial for this treatment was completed in 2017 by Apexigen, Inc. In total, 41 patients were involved in Phase 1 & 2 of the study. From 2017 to now, 3 more trials have been undertaken."

"This trial is seeking 58 individuals who have prepared advance directives. These patients must be between 18 and 99 years of age, meet the following criteria:-18 years or older -Able to provide written informed consent -Pathologic diagnosis of rectal adenocarcinoma -Distal (<1cm from anal ring), cT4 or within 3mm of MR fascia -Not a candidate for sphincter preservation -Extramural venous invasion -No prior treatment for rectal adenocarcinoma -Eastern Cooperative Group (ECOG"

"To be eligible for this particular clinical trial, patients must between 18 to 99 years old. Out of the 1,102 total clinical trials hosted on this website, only 19 are for minors and 1083 are for senior citizens."

"University of Texas MD Anderson Cancer Center first studied APX005M, mFOLFOX, and Radiation Therapy 5Gy x 5 days in 2017. So far, 3 clinical trials have completed with 7 more active studies underway--a large number of which are taking place in Winston-Salem, North carolina."

"This study is no longer recruiting patients. The earliest posting date was April 24th, 2020 and the most recent edit was on July 14th, 2022. However, there are 1081 other trials that may be of interest which are actively admitting patients with advance directives and 7 trials for APX005M, mFOLFOX, and Radiation Therapy 5Gy x 5 days that are currently seeking new candidates."

"This study has six total locations, three of which are Wake Forest Baptist Health Sciences in Winston-Salem, North carolina, Moffitt Cancer Center in Tampa, Florida, and Oregon Health & Science University in Portland, Oregon."