Gilenya

Relapsing Remitting Multiple Sclerosis, Multiple Sclerosis, Carcinoma in Situ + 2 more
Treatment
20 Active Studies for Gilenya

What is Gilenya

FingolimodThe Generic name of this drug
Treatment SummaryFingolimod is a drug used to treat symptoms of multiple sclerosis (MS). It works by blocking receptors that cause inflammation and damage to nerve cells. The drug was created by Novartis and approved by the FDA in 2010. Currently, Fingolimod is being studied as a potential treatment for the novel coronavirus (COVID-19). Clinical trials are expected to end in July 2020.
Gilenyais the brand name
image of different drug pills on a surface
Gilenya Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Gilenya
Fingolimod
2010
16

Effectiveness

How Gilenya Affects PatientsFingolimod is a drug used to treat multiple sclerosis and possibly COVID-19. It works by binding to certain receptors in the body, reducing inflammation in the brain for MS patients, and potentially in the lungs for COVID-19 patients. It may also cause a temporary slower heart rate and longer QT intervals.
How Gilenya works in the bodySphingosine-1-phosphate (S1P) is a molecule found in the body that binds to several different receptors. These receptors can be found in the immune, cardiovascular, pulmonary, and nervous systems. Fingolimod phosphate is a drug that binds to certain S1P receptors and helps reduce inflammation associated with multiple sclerosis. It does this by keeping some lymphocytes from leaving lymph nodes and preventing them from entering the central nervous system. While it isn't typically used to treat SARS-CoV-2 pneumonia, it may be helpful in preventing acute respiratory distress syndrome (ARDS) associated with COVID

When to interrupt dosage

The prescribed quantity of Gilenya is contingent upon the diagnosed condition, such as Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis (RRMS) and Alternative Treatment. Dosage shifts in accordance with the method of delivery (e.g. Capsule - Oral or Capsule) noted in the accompanying table.
Condition
Dosage
Administration
Carcinoma in Situ
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral
Relapsing Remitting Multiple Sclerosis
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral
Multiple Sclerosis
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral
Multiple Sclerosis
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral
Alternative Treatment
, 0.5 mg, 0.25 mg
, Oral, Capsule, Capsule - Oral

Warnings

Gilenya has fifteen contra-indications, so it should not be employed in combination with any of the conditions in the subsequent table.Gilenya Contraindications
Condition
Risk Level
Notes
Atrioventricular Block
Do Not Combine
Atrioventricular Block
Do Not Combine
Stroke
Do Not Combine
Angina, Unstable
Do Not Combine
Transient Ischemic Attack (TIA)
Do Not Combine
Atrioventricular Block
Do Not Combine
Heart Decompensation
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Heart failure
Do Not Combine
Pulse Frequency
Do Not Combine
Atrioventricular Block
Do Not Combine
Pulse Frequency
Do Not Combine
Heart Attack
Do Not Combine
Pulse Frequency
Do Not Combine
Heart failure
Do Not Combine
There are 20 known major drug interactions with Gilenya.
Common Gilenya Drug Interactions
Drug Name
Risk Level
Description
Adenovirus type 7 vaccine live
Major
The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Fingolimod.
Ajmaline
Major
Fingolimod may increase the arrhythmogenic activities of Ajmaline.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Fingolimod.
Amiodarone
Major
Fingolimod may increase the arrhythmogenic activities of Amiodarone.
Anthrax vaccine
Major
The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Fingolimod.
Gilenya Toxicity & Overdose RiskThe toxic dose of fingolimod in rats is between 300-600mg/kg. If someone has an overdose of fingolimod, they may experience low blood pressure and a slow heartbeat, which can be treated with atropine. It is also possible to experience heart block or cardiotoxicity due to the drug's known side effect.
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Gilenya Novel Uses: Which Conditions Have a Clinical Trial Featuring Gilenya?

Currently, 44 active clinical trials are exploring the potential of Gilenya to combat active Secondary Progressive Multiple Sclerosis (SPMS), Multiple Sclerosis and Carcinoma in Situ.
Condition
Clinical Trials
Trial Phases
Multiple Sclerosis
12 Actively Recruiting
Phase 3, Phase 4, Phase 2, Phase 1
Relapsing Remitting Multiple Sclerosis
14 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Early Phase 1
Alternative Treatment
0 Actively Recruiting
Multiple Sclerosis
0 Actively Recruiting
Carcinoma in Situ
3 Actively Recruiting
Not Applicable, Phase 4

Gilenya Reviews: What are patients saying about Gilenya?

5Patient Review
1/25/2016
Gilenya for Relapsing Form of Multiple Sclerosis
I've been taking Gilenya for five years and it's worked great for me. I only wish that Novartis would lower their price to make the drug more affordable.
5Patient Review
4/6/2016
Gilenya for Relapsing Form of Multiple Sclerosis
I've been dealing with MS since 1990 and on interferon b1b since 1995. Recently, the interferon was no longer helping me, so I switched to Gilenya about a year ago. The results have been amazing—I can walk long distances without issue and feel well enough to work a lot more.
5Patient Review
10/3/2020
Gilenya for Relapsing Form of Multiple Sclerosis
Gilenya has been an absolute wonder drug for me. I enrolled in a study for it 12 years ago after my second lesion and have not had any new ones since then. The only side effects I've experienced are slightly elevated liver enzymes and an increase in cold sores for the first six months.
5Patient Review
11/6/2015
Gilenya for Relapsing Form of Multiple Sclerosis
I was diagnosed in 2010 and started on Rebif. Within a year, I had a new lesion on my brain despite the treatment. My doctor was initially against Gilenya because it had only recently been approved; however, I've been doing much better since switching. I do have to get bloodwork and MRI's every few months, but that's a small price to pay for feeling normal again.
5Patient Review
1/11/2016
Gilenya for Relapsing Form of Multiple Sclerosis
I feel great and have experienced zero side effects!
View All Reviews
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Patient Q&A Section about gilenya

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does Gilenya for MS work?

"Gilenya prevents white blood cells from crossing into the central nervous system and causing inflammation and damage."

Answered by AI

What are the side effects of Gilenya?

"Some of the more common side effects associated with taking Gilenya include headaches, issues with liver function as shown by abnormal liver tests, diarrhea, cough, flu, sinusitis, back pain, and abdominal pain. Additionally, some people may also experience pain in their arms or legs."

Answered by AI

What is Gilenya used for?

"The United States Food and Drug Administration has approved Gilenya for the treatment of relapsing forms of multiple sclerosis in patients aged ten and above, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease."

Answered by AI

What kind of medication is Gilenya?

"Gilenya is a medication used to treat relapsing multiple sclerosis (MS). It is available as 0.5 mg capsules and is taken once daily by mouth. Common side effects include cough, headache, back pain, and diarrhea."

Answered by AI

Clinical Trials for Gilenya

Have you considered Gilenya clinical trials? We made a collection of clinical trials featuring Gilenya, we think they might fit your search criteria.
Have you considered Gilenya clinical trials? We made a collection of clinical trials featuring Gilenya, we think they might fit your search criteria.
Have you considered Gilenya clinical trials? We made a collection of clinical trials featuring Gilenya, we think they might fit your search criteria.