Wearable Focal Vibration Therapy for Multiple Sclerosis

Overseen By Hongwu Wang, PhD

Age: 18+

Sex: Any

Trial Phase: Phase < 1

Sponsor: University of Florida

Disqualifiers: Cognitive impairment, Stroke, Severe carpal tunnel, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

Duration: 4 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This pilot mixed-method study will evaluate the feasibility, preliminary efficacy, and user experience of a home-based wearable Focal Vibration Therapy (FVT) intervention for improving upper extremity (UEx) function in people with multiple sclerosis (MS). Fifteen adults with relapsing-remitting MS (PRMS) and self-reported UEx impairments will participate in a 4-week FVT program using MyovoltTM wearable FVT devices applied to arm muscles.

Who Is on the Research Team?

Hongwu Wang

Principal Investigator

University of Florida

Are You a Good Fit for This Trial?

This trial is for adults with relapsing-remitting Multiple Sclerosis who have trouble with arm functions. It's a small study to see if wearing a vibration device on the arm helps improve movement and strength.

Inclusion Criteria

I experience issues with my arm or hand, such as weakness, stiffness, or pain.

I am over 18 years old.

I have been diagnosed with relapsing-remitting MS.

Exclusion Criteria

Evidence of cognitive impairment that could interfere with following instructions (Mini-Montreal Cognitive Assessment score (Mini-MoCA) < 12)

I don't have conditions that make vibration therapy unsafe for me.

I don't have severe nerve or mental health issues that could affect my arms.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a 4-week Focal Vibration Therapy (FVT) program using MyovoltTM wearable devices applied to arm muscles

4 weeks

Home-based, monitored via MyoVolt app

Follow-up

Participants are monitored for safety and effectiveness after treatment, including assessments of motor function and usability

4 weeks

In-person assessments at week 4 and week 8

What Are the Treatments Tested in This Trial?

Interventions

• Wearable Focal Vibration Therapy

Trial Overview

The study tests wearable Focal Vibration Therapy (FVT) using MyovoltTM devices on the arms of participants. Over four weeks, it will assess how feasible this therapy is at home and its potential benefits for arm function in MS patients.

How Is the Trial Designed?

Group I: Intervention group Experimental Treatment 1 Intervention

Participants who will recieve the focal vibration therapy

Who Is Running the Clinical Trial?

University of Florida

Lead Sponsor

Trials

1,428

Recruited

987,000+