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What is Gemtesa
VibegronThe Generic name of this drug
Treatment SummaryVibegron is a medication used to treat overactive bladder in adults. It works by relaxing the muscle of the bladder to increase bladder capacity. Vibegron is the second type of drug in its class to be approved for this purpose, following Mirabegron, which was approved in 2012. Vibegron is less likely to interact with other drugs, making it a safer choice for patients. It is available as an oral tablet brand called GEMTESA.
Gemtesais the brand name
Gemtesa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Gemtesa
Vibegron
2020
1
Effectiveness
How Gemtesa Affects PatientsVibegron is a drug that helps improve symptoms of an overactive bladder. It works by increasing the size of the bladder and slowing down bladder contractions, so that people can go longer between bathroom trips. Clinical studies in Japanese patients with overactive bladders showed that vibegron improved the frequency of bathroom trips, urgency, and urgency incontinence episodes. Compared to other beta-receptors, vibegron is much more selective for beta-3 receptors, which makes it more effective for treating overactive bladders.
How Gemtesa works in the bodyOveractive bladder is caused by poor communication between the bladder and the brain, leading to abnormal bladder sensations. Vibegron is a medication that helps treat overactive bladder by interacting with beta-3 adrenaline receptors. This interaction stimulates the formation of cyclic adenosine monophosphate, which helps relax the muscles of the bladder and reduce the urge to urinate. Vibegron also works by affecting sensory mechanisms without directly affecting the bladder muscles.
When to interrupt dosage
The encouraged measure of Gemtesa relies upon the confirmed condition. The amount of dosage changes, as per the administration procedure featured in the below-listed table.Condition
Dosage
Administration
Overactive Bladder Syndrome
75.0 mg,
Tablet, film coated, Tablet, film coated - Oral, Oral,
Warnings
Gemtesa has one counterindication, and it should not be administered while having any of the conditions in the following table.Gemtesa ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Vibegron may interact with Pulse Frequency
Common Gemtesa Drug Interactions
Drug Name
Risk Level
Description
Acetyldigoxin
Moderate
The serum concentration of Acetyldigoxin can be increased when it is combined with Vibegron.
Benzylpenicilloyl polylysine
Moderate
Vibegron may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Digoxin
Moderate
The serum concentration of Digoxin can be increased when it is combined with Vibegron.
Formoterol
Moderate
Vibegron may increase the sympathomimetic activities of Formoterol.
Metildigoxin
Moderate
The serum concentration of Metildigoxin can be increased when it is combined with Vibegron.
Gemtesa Toxicity & Overdose RiskIf a vibegron overdose is suspected, supportive and symptomatic treatments should be started. There is not a lot of information available about overdosing on vibegron.
Gemtesa Novel Uses: Which Conditions Have a Clinical Trial Featuring Gemtesa?
32 active trials are in progress to assess the efficacy of Gemtesa in providing symptomatic relief for Overactive Bladder Syndrome.Condition
Clinical Trials
Trial Phases
Overactive Bladder Syndrome
32 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
Gemtesa Reviews: What are patients saying about Gemtesa?
5Patient Review
1/17/2022 I saw a great response on the second day of taking this pill. I take it alongside a diuretic and it's helped me to better control my bathroom needs.
5Patient Review
10/9/2021 After using this medication for just a week, I found it to be more effective than other treatments I've tried in the past for my OAB.
4.3Patient Review
1/26/2022 This medication was effective for me when I first started using it; however, now my symptoms have returned and I am not getting the same relief.
4Patient Review
7/2/2021 So far, I've been using this for two days and it has definitely cut down on how often I have to go to the bathroom. But now I'm starting to worry that I might be retaining urine. Is there any way to tell?
3.3Patient Review
11/5/2022 When I first started taking this medication, I was amazed at how well it worked. There were no more accidents or issues with my overactive bladder. However, I suddenly developed terrible diarrhea and other Irritable Bowel Syndrome symptoms, so I had to stop taking it.
3Patient Review
6/12/2022 This medication caused my feet to swell and made it difficult to urinate. I stopped taking it immediately after consulting with a urologist, as this is a known side effect of the drug.
3Patient Review
8/23/2022 Initially, this medication helped me a lot with my overactive bladder. However, it stopped being effective after a few months and made my sinus problems worse. Once I stopped taking it, I felt much better.
2.7Patient Review
6/20/2022 I experienced constipation after taking this medication for just a few days. This is a common side effect of many medications, but this one is very expensive (over $500 per month) and not covered by insurance.
2.7Patient Review
3/31/2022 I haven't seen any improvement in my urge incontinence since starting this medication. I'm extremely disappointed.
2.3Patient Review
4/15/2022 Even when taking Gemtessa regularly, I experienced a lot of urinary accidents. The drug also caused my feet to swell. Overall, not a great experience.
2Patient Review
1/13/2022 While this medication did work to stop my OAB symptoms, after taking it for 2 weeks my whole body and scalp were itching. I began losing TONS of hair every day. Like handfuls of hair were suddenly falling out. As soon as I realized it was the medication, I stopped taking it and my hair loss also slowed down almost immediately. Be very careful with this medication!
2Patient Review
6/17/2022 My mother experienced urine retention after taking this medication for two months and was then admitted to the hospital due to acute kidney disease. She is now using a catheter and stopped taking the medication on 6/11/22. If anyone has any information about how long it will take for her to urinate again, please let me know as the urologist was unable to give me a straight answer.
2Patient Review
7/2/2022 This medication unfortunately made my condition worse. I had to stop taking it and go back to Vesicare.
1Patient Review
7/19/2022 This medication was great for the first week, but then the constipation I experienced was unbearable. The medication stopped working after that. I stuck it out for about four months, switched back to Myrbetriq, and the constipation is gone.
Patient Q&A Section about gemtesa
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How quickly does GEMTESA work?
"Gemtesa begins working after you take your first dose of medication. In clinical studies, people had decreased urinary incontinence, urgency, and frequency within 12 weeks."
Answered by AI
Is GEMTESA better than Myrbetriq?
"The beta-3 agonist class of medication (which includes Gemtesa) has numerous advantages over the anti-cholinergic class of medications (Detrol, Ditropan, VESIcare, Enablex, Sanctura, Toviaz) in terms of simple dosing, ability to crush, no worries about blood pressure, and less drug-drug interactions."
Answered by AI
What is GEMTESA prescribed for?
"This sudden urge can happen even when your bladder is not full.
This medication is used in order to treat an overactive bladder. An overactive bladder is a problem where your bladder cannot store urine properly, resulting in a sudden urge to urinate even when your bladder is not full."
Answered by AI