Pumpkin Seed Extract for Overactive Bladder
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if pumpkin seed oil extract can help individuals with overactive bladder issues. It focuses on bladder functions such as frequent urination or sudden urges, with or without leaks. Participants will take one pumpkin seed oil pill daily for 12 weeks. The trial seeks individuals who have experienced these bladder problems and are willing to try a dietary supplement without introducing other new treatments during this period. As an unphased trial, it offers participants the chance to explore a natural remedy for bladder issues without committing to other treatments.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop your current medications, but you cannot start any new overactive bladder medications or supplements during the study or in the 3 months before joining.
What prior data suggests that pumpkin seed oil extract is safe for bladder function?
Research has shown that pumpkin seed oil extract is generally safe for people. One study found that using pumpkin seed extract is safe and well-tolerated, with no major risks for those using it to help with an overactive bladder. Another study reported that pumpkin seed oil improved urinary issues in people with an overactive bladder without causing serious side effects.
These findings suggest that most people can easily tolerate pumpkin seed oil extract. However, consulting a healthcare provider before starting any new supplement is always advisable, especially if other medications are being taken.12345Why are researchers excited about this trial?
Unlike the standard treatments for overactive bladder, which often include medications like anticholinergics or beta-3 adrenergic agonists, pumpkin seed extract offers a natural alternative. Researchers are excited about this treatment because it contains compounds that may help strengthen the bladder and improve urinary function without the common side effects associated with traditional medications, such as dry mouth or constipation. Additionally, the convenience of a once-daily oral supplement makes it an attractive option for those looking for a simple and natural way to manage their symptoms.
What evidence suggests that pumpkin seed oil extract might be an effective treatment for overactive bladder?
Research has shown that pumpkin seed oil extract, which participants in this trial will receive, can help with urinary issues such as overactive bladder (OAB). Studies have found that extracts from pumpkin seeds, particularly from the Cucurbita maxima type, significantly improve bladder symptoms. For instance, one study found that pumpkin seed oil reduced the Overactive Bladder Symptom Score (OABSS), which measures symptom severity. Another study demonstrated that a mix of pumpkin seed extract improved urinary incontinence. These findings suggest that pumpkin seed oil extract may benefit individuals with bladder problems.12367
Are You a Good Fit for This Trial?
This trial is for individuals with overactive bladder symptoms who are patients at Northwestern's IPHP. They must be willing to take a dietary supplement and not start other treatments for 12 weeks after beginning the pumpkin seed oil extract. People can't join if they have certain bladder issues, use similar supplements, don't speak English, or have had recent pelvic surgery.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 1000mg of pumpkin seed oil extract daily for 12 weeks
Follow-up
Participants complete follow-up questionnaires to assess changes in bladder function and supplement adherence
What Are the Treatments Tested in This Trial?
Interventions
- Pumpkin Seed Oil Extract
Trial Overview
The study is testing whether taking pumpkin seed oil extract as a dietary supplement improves bladder function in people with an overactive bladder. This pilot study will measure outcomes based on validated methods within a U.S. population.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Upon a patient's enrollment into the study and completion of initial study questionnaires, a research team member will provide the patient with a single bottle of pumpkin seed oil extract. Enrolled patients will be instructed to initiate using the pumpkin seed oil extract starting the day they receive the supplement. Patients will start taking one pill by mouth per day for 12 weeks. They will also be advised to contact their urogynecologist for follow-up if they have not noticed improvement in their bladder health following 3 months of use. Furthermore, they will be counseled about not starting new medications or supplements during their time as a study participant and not sharing their pumpkin seed oil extract with anyone else during their time as a study participant.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor
Citations
Pumpkin Seed Oil Extracted From Cucurbita maxima ...
The results from our study suggest that pumpkin seed oil extracts from C. maxima as well as from C. pepo are effective for urinary disorders such as OAB in ...
A randomized double-blind placebo-controlled clinical trial ...
Studies performed in the past showed that a premixed blend of pumpkin seed extract and soy germ extract was able to improve urinary incontinence as well as BPH ...
Evaluating Pumpkin Seed Oil Extract Supplementation on ...
This is a pilot study to assess using validated outcome measures how ingesting pumpkin seed oil extract supports patient bladder function in a United States ...
4.
researchgate.net
researchgate.net/publication/262695548_Pumpkin_Seed_Oil_Extracted_From_Cucurbita_maxima_Improves_Urinary_Disorder_in_Human_Overactive_Bladder(PDF) Pumpkin Seed Oil Extracted From Cucurbita maxima ...
The results from our study suggest that pumpkin seed oil extracts from C. maxima as well as from C. pepo are effective for urinary disorders such as OAB in ...
Pumpkin seed oil extracted from Cucurbita maxima ...
Pumpkin seed oil from C. maxima significantly reduced the degree of OABSS in the subjects. The results from our study suggest that pumpkin seed ...
Pumpkin Seed for Overactive Bladder: Does It Really Work?
So far, research has yet to identify major risks from using pumpkin seed oil or extract as a supplement for overactive bladder. But not much is ...
Herbal Supplements for Overactive Bladder
Pumpkin seed oil extracted from Cucurbita maxima improves urinary disorder in human overactive bladder. J Trad Comp Med. 2014;4(1):72-74 ...
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