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Neuromodulation

Transcranial magnetic stimulation for Urge Incontinence (TMS_OAB Trial)

N/A
Recruiting
Research Sponsored by The Methodist Hospital Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Females & Males 40 to 80 years old
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up post-intervention at: 1 day, 3 weeks, 6 weeks
Awards & highlights

TMS_OAB Trial Summary

This trial aims to investigate the effects of a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) on adults with overactive bladder (OAB). OAB can

Who is the study for?
This trial is for adults with overactive bladder (OAB), which may include symptoms like urinary incontinence, bedwetting, and urge incontinence. Participants should be experiencing a significant impact on their quality of life due to OAB. The eligibility criteria are not fully listed here.Check my eligibility
What is being tested?
The study is testing the use of repetitive transcranial magnetic stimulation (rTMS) as a non-invasive treatment for OAB. rTMS aims to normalize brain activity that could be linked to OAB symptoms. This trial will also explore changes in the brain and how they relate to improvements in symptoms.See study design
What are the potential side effects?
While specific side effects for this trial aren't detailed, rTMS is generally considered safe and has been used safely in elderly populations and those with cognitive impairments.

TMS_OAB Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 40 and 80 years old.

TMS_OAB Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~post-intervention at: 1 day, 3 weeks, 6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and post-intervention at: 1 day, 3 weeks, 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Functional connectivity
Regional brain activity
Secondary outcome measures
OAB Symptom Bother
OAB related Quality of life
Pelvic floor muscle activity
+2 more

TMS_OAB Trial Design

1Treatment groups
Experimental Treatment
Group I: Transcranial magnetic stimulationExperimental Treatment1 Intervention
All study subjects undergo five sessions of rTMS. The 40-minute sessions target the supplemental motor area (inhibitory stimulation) and prefrontal cortex (excitatory stimulation)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial Magnetic Stimulation
2017
Completed Phase 4
~730

Find a Location

Who is running the clinical trial?

The Methodist Hospital Research InstituteLead Sponsor
274 Previous Clinical Trials
80,525 Total Patients Enrolled
Michelle Almarez, BBAStudy DirectorHouston Methodist Obstetrics & Gynecology Department

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the main goals and purposes of this clinical investigation?

"The primary goal of this research is to examine functional connectivity, which will be assessed within 0 to 3 days after the intervention. Secondary objectives encompass evaluating OAB-related quality of life using the OAB-q health-related quality of life score (with higher scores indicating better outcomes), analyzing pelvic floor muscle activity through surface electromyography during rTMS sessions while subjects are at rest, and measuring urinary frequency with a two-day bladder diary to determine mean voids per 24 hours (higher scores indicate worse outcomes)."

Answered by AI

Is the inclusion criteria for this research limited to individuals aged 25 years and above?

"As per the eligibility requirements outlined in this trial, individuals aged 40 and above up to 80 years old are eligible for participation."

Answered by AI

What is the upper limit in terms of patient enrollment for this medical study?

"Indeed, as per the information on clinicaltrials.gov, this ongoing clinical trial is actively seeking individuals for participation. The trial was initially posted on January 8th, 2024 and most recently updated on the same day. To meet its objectives, the study aims to recruit a total of 10 participants from one location."

Answered by AI

Are there any available openings for patients to participate in this medical study?

"Indeed, as per the information available on clinicaltrials.gov, this study is currently in the recruitment phase. The trial was initially posted on January 8th, 2024 and has been recently updated on the same date. It aims to enroll a total of 10 patients from one designated location."

Answered by AI

Which individuals are eligible to participate in this clinical research study?

"In order to qualify for participation in this clinical trial, individuals must exhibit symptoms of urinary incontinence and fall within the age range of 40 to 80 years. The study is currently seeking a total of 10 eligible participants."

Answered by AI

Who else is applying?

What site did they apply to?
Houston Methodist Hospital
What portion of applicants met pre-screening criteria?
Met criteria

Why did patients apply to this trial?

Really my curiosity lead me here.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
rTMS in Overactive Bladder
2024. "rTMS in Overactive Bladder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06198439.
All > Overactive Bladder
~7 spots leftby Mar 2026
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