Ferumoxytol

Iron Deficiency Anemia, Chronic Kidney Disease
Treatment
2 FDA approvals
20 Active Studies for Ferumoxytol

What is Ferumoxytol

FerumoxytolThe Generic name of this drug
Treatment SummaryFerumoxytol is a medication used to treat iron deficiency anemia in adults with chronic kidney disease. It is given through an intravenous injection and is a solution of iron oxide nanoparticles coated in a semi-synthetic carbohydrate shell. The injection is given at a high dose and quickly goes into the bloodstream.
Feridexis the brand name
image of different drug pills on a surface
Ferumoxytol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Feridex
Ferumoxytol
2008
3

Approved as Treatment by the FDA

Ferumoxytol, otherwise known as Feridex, is approved by the FDA for 2 uses including Iron Deficiency Anemia and Chronic Kidney Disease .
Iron Deficiency Anemia
Chronic Kidney Disease

Effectiveness

How Ferumoxytol Affects PatientsFerumoxytol is a drug used to measure hemoglobin, serum ferritin, and transferrin saturation levels. It has been shown to be more effective than oral iron in clinical studies. It can also be used as a contrast agent for MRI scans, as it stays in the bloodstream and allows for data collection over a longer period of time. Iron is important for many bodily functions, including oxidation-reduction reactions and enzymes in the mitochondria. Low iron levels can lead to anemia, decreased oxygen delivery, and learning or thermoregulation defects.
How Ferumoxytol works in the bodyFeraheme is a drug made of iron covered by a carbohydrate shell. When this drug enters the body, the shell breaks apart and releases iron. This iron is then stored in the body or used to make hemoglobin. Iron is important for many processes in the body including allowing cells to use oxygen and regulating the body's temperature. Feraheme replaces iron stores more effectively than oral iron supplements and can also be used to make MRI images of the body by darkening contrast media-containing structures.

When to interrupt dosage

The measure of Ferumoxytol is contingent upon the diagnosed condition. The amount likewise fluctuates as per the technique of delivery (e.g. Injection - Intravenous or Solution) noted in the table underneath.
Condition
Dosage
Administration
Iron Deficiency Anemia
, 30.0 mg/mL, 0.051 mg/mL, 51.0 mg/mL, 11.2 mg/mL
, Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous
Chronic Kidney Disease
, 30.0 mg/mL, 0.051 mg/mL, 51.0 mg/mL, 11.2 mg/mL
, Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous

Warnings

There are 20 known major drug interactions with Ferumoxytol.
Common Ferumoxytol Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Ferumoxytol can cause a decrease in the absorption of Technetium Tc-99m oxidronate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Minor
Ferumoxytol can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium Phosphate
Minor
Ferumoxytol can cause a decrease in the absorption of Calcium Phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium phosphate dihydrate
Minor
Ferumoxytol can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dipotassium phosphate
Minor
Ferumoxytol can cause a decrease in the absorption of Dipotassium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferumoxytol Toxicity & Overdose RiskFeraheme may cause serious allergic reactions, including anaphylaxis, which were reported in 0.2% of people who used it. Other allergic reactions such as itching, rash, hives, or wheezing were reported in 3.7% of people who used it. It has not been tested to determine if it can cause cancer, and studies have not found it to cause fertility issues in animals. Feraheme may also cause low blood pressure, iron overload, and alterations to MRI imaging, which could last up to 12 weeks after the last dose.
image of a doctor in a lab doing drug, clinical research

Ferumoxytol Novel Uses: Which Conditions Have a Clinical Trial Featuring Ferumoxytol?

118 active studies are currently being conducted to evaluate the effectiveness of Ferumoxytol for the amelioration of Iron deficiency anemia.
Condition
Clinical Trials
Trial Phases
Iron Deficiency Anemia
11 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 2
Chronic Kidney Disease
109 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1

Patient Q&A Section about ferumoxytol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Feraheme?

"Dizziness, fainting, low blood pressure, injection site reactions, nausea, vomiting, stomach pain, and diarrhea are all possible side effects of this medication."

Answered by AI

What is the brand name for ferumoxytol?

"Feraheme is a drug used to treat iron deficiency anemia. It is given as an injection and works by replacing the iron in the body."

Answered by AI

What is ferumoxytol made of?

"Ferumoxytol is an intravenous iron preparation that is used to treat the anemia of chronic kidney disease (CKD). It is a carbohydrate-coated, superparamagnetic iron oxide nanoparticle. Because there is very little free iron in the preparation, doses of 510 mg have been safely administered in as little as 17 seconds."

Answered by AI

What is ferumoxytol injection for?

"Ferumoxytol is an iron replacement product that is injected to treat iron deficiency anemia in patients with chronic kidney disease or who have not had success with taking oral iron supplements in the past."

Answered by AI

Clinical Trials for Ferumoxytol

Have you considered Ferumoxytol clinical trials? We made a collection of clinical trials featuring Ferumoxytol, we think they might fit your search criteria.
Have you considered Ferumoxytol clinical trials? We made a collection of clinical trials featuring Ferumoxytol, we think they might fit your search criteria.
Have you considered Ferumoxytol clinical trials? We made a collection of clinical trials featuring Ferumoxytol, we think they might fit your search criteria.