Exercise Regimen for Lung Cancer

(PILOT PERCC Trial)

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Utah

Disqualifiers: Morbid obesity, Anorexia, Alcohol abuse, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

20 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Precision Exercise Regimen for Cancer Care (PERCC) for lung cancer?

Research shows that exercise can be beneficial for people with lung cancer, improving their fitness and quality of life. Studies have found that exercise during chemotherapy and structured exercise programs can help patients with non-small cell lung cancer manage symptoms and improve their overall well-being. ^{1 2 3 4 5}

Is exercise safe for people with lung cancer?

Current evidence suggests that exercise is generally safe for people with lung cancer, both before and after surgery. However, more studies are needed to confirm safety for those with inoperable lung cancer. ^{1 3 6 7 8}

How is the treatment PERCC different from other treatments for lung cancer?

The Precision Exercise Regimen for Cancer Care (PERCC) is unique because it focuses on a personalized exercise program specifically designed for lung cancer patients, aiming to improve their physical function and quality of life. Unlike traditional treatments, PERCC emphasizes exercise as a safe and feasible adjunct therapy across the lung cancer care continuum, from prevention to palliation. ^{1 3 8 9 10}

What is the purpose of this trial?

This study is designed to evaluate whether a precision exercise regimen is feasible to implement within cancer populations, specifically stage II-III primary lung cancer patients receiving multimodal therapy, and delivered through telehealth.

Eligibility Criteria

This trial is for adults over 18 diagnosed with stage II or III non-small cell lung cancer (NSCLC), who are about to receive or currently receiving neoadjuvant chemotherapy or immunotherapy and surgery. Participants must be able to follow instructions in English/Spanish, complete questionnaires, and commit to the PERCC exercise program.

Inclusion Criteria

Patient agrees to complete the PERCC intervention

I am getting chemotherapy or immunotherapy before surgery.

I was 18 or older when I was diagnosed.

Exclusion Criteria

Alcohol or drug abuse, significant mental or emotional problems that would interfere with compliance (assessed by NCCN Distress Thermometer)

My BMI is either above 40 or below 17.5.

I have no physical issues preventing me from joining an exercise program.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Pre-treatment Exercise

Participants engage in a virtually supervised home-based exercise program starting at least two weeks before receiving their first neoadjuvant treatment

2 weeks

Virtual supervision

Treatment and Exercise

Participants continue the exercise regimen during multimodal therapy until two months post-surgery

Approximately 4 months

Virtual supervision

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 months

Treatment Details

Interventions

• Precision Exercise Regimen for Cancer Care (PERCC)

Trial Overview The study tests if a tailored exercise regimen delivered via telehealth is practical for stage II-III NSCLC patients undergoing multimodal therapy. The Precision Exercise Regimen for Cancer Care (PERCC) aims to see how well patients can stick to this fitness routine.

Participant Groups

Group I: Precision Exercise Regimen for Cancer Care (PERCC) Experimental Treatment 1 Intervention

Participants will engage in PERCC starting at least two weeks prior to receiving their first neoadjuvant treatment for lung cancer and continuing until two months after receiving surgical treatment.

Who Is Running the Clinical Trial?

University of Utah

Lead Sponsor

Trials

1,169

Recruited

1,623,000+

Findings from Research

The study assessed the feasibility of an 8-week hospital-based exercise program for 25 patients with advanced non-small cell lung cancer, finding that while 80% started the program, only 44% completed all sessions.

Patients who completed the exercise program reported significant improvements in lung cancer symptoms without any decline in their functional capacity, suggesting that structured exercise can be beneficial for those who can adhere to it.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

A structured exercise program for patients with advanced non-small cell lung cancer. Temel, JS., Greer, JA., Goldberg, S., et al.[2021]

Exercise interventions for lung cancer patients significantly reduce post-operative complications and improve exercise capacity, based on a systematic review of 30 studies involving a total of 6440 participants.

While exercise showed benefits in pre- and post-operative settings, health-related quality of life improvements were mostly non-significant, indicating a need for further high-quality research, especially in non-surgical populations.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews. Edbrooke, L., Bowman, A., Granger, CL., et al.[2023]

The LUNGEVITY trial will evaluate the effects of different exercise training types on cardiorespiratory fitness (VO2peak) and patient-reported outcomes in 160 post-operative non-small cell lung cancer patients over 16 weeks.

The study aims to determine the most effective exercise regimen (aerobic, resistance, or a combination) for improving fitness and quality of life, which could lead to new rehabilitation guidelines for lung cancer survivors.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The lung cancer exercise training study: a randomized trial of aerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design. Jones, LW., Eves, ND., Kraus, WE., et al.[2021]

Exercise training is a safe and feasible adjunct therapy for patients with operable lung cancer, both before and after surgery, helping to improve their ability to tolerate exercise and potentially enhancing their quality of life.

For patients with inoperable lung cancer, while more research is needed, preliminary evidence indicates that carefully prescribed exercise training could also be beneficial and should be considered in their overall treatment plan.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Exercise therapy across the lung cancer continuum. Jones, LW., Eves, ND., Waner, E., et al.[2021]

References

1. United States pubmed.ncbi.nlm.nih.gov

A structured exercise program for patients with advanced non-small cell lung cancer. [2021]

2. Ireland pubmed.ncbi.nlm.nih.gov

Exercise intervention to improve exercise capacity and health related quality of life for patients with Non-small cell lung cancer: a systematic review. [2022]

3. Switzerland pubmed.ncbi.nlm.nih.gov

Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews. [2023]

4. United States pubmed.ncbi.nlm.nih.gov

Exercise Training in Patients With Non-Small Cell Lung Cancer During In-Hospital Chemotherapy Treatment: A RANDOMIZED CONTROLLED TRIAL. [2020]

5. England pubmed.ncbi.nlm.nih.gov

The lung cancer exercise training study: a randomized trial of aerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design. [2021]

6. United States pubmed.ncbi.nlm.nih.gov

The Utility of Exercise Testing in Patients with Lung Cancer. [2019]

7. United States pubmed.ncbi.nlm.nih.gov

Association of Exercise Behavior with Overall Survival in Stage I-IIIA Lung Cancer. [2021]

8. United States pubmed.ncbi.nlm.nih.gov

Exercise therapy across the lung cancer continuum. [2021]

9. England pubmed.ncbi.nlm.nih.gov

Systematic short-term pulmonary rehabilitation before lung cancer lobectomy: a randomized trial. [2022]

10. United States pubmed.ncbi.nlm.nih.gov

A Patient-Centered Activity Regimen Improves Participation in Physical Activity Interventions in Advanced-Stage Lung Cancer. [2019]