CLINICAL TRIAL

Moderate Intensity, High Volume Exercise Training for Vascular Diseases

Recruiting · 18 - 65 · All Sexes · Richmond, VA

This study is evaluating whether exercise training can improve blood vessel function in healthy individuals and people with mental health disorders.

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About the trial for Vascular Diseases

Eligible Conditions
Vascular Diseases · Peripheral Vascular Diseases · Mental Disorders · Peripheral Arterial Disease

Treatment Groups

This trial involves 3 different treatments. Moderate Intensity, High Volume Exercise Training is the primary treatment being studied. Participants will be divided into 3 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
High Intensity, Normal Volume Exercise Training
BEHAVIORAL
Experimental Group 2
Moderate Intensity, High Volume Exercise Training
BEHAVIORAL
Experimental Group 3
Moderate Intensity, Normal Volume Exercise Training
BEHAVIORAL

Eligibility

This trial is for patients born any sex between 18 and 65 years old. There are 4 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
The GAD group is defined as people with a score of ≥ 10 on the GAD-7 self-report scale and < 33 on the PCL-5 checklist. show original
The group of healthy people had a score of ≤ 10 on the GAD-7 self-report scale and < 33 on the PCL-5 checklist. show original
The person appears to be healthy and free of any obvious heart, lung, or metabolic problems. show original
suggests significant psychopathology For people with PTSD, a score of 33 or more on the PCL-5 checklist suggests significant psychopathology. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Baseline to the end of the final visit, about 14 weeks
Screening: ~3 weeks
Treatment: Varies
Reporting: Baseline to the end of the final visit, about 14 weeks
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Baseline to the end of the final visit, about 14 weeks.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Moderate Intensity, High Volume Exercise Training will improve 3 primary outcomes in patients with Vascular Diseases. Measurement will happen over the course of Baseline to the end of the final visit, about 14 weeks.

Leg Vascular Function (Passive Leg Movement Test)
BASELINE TO THE END OF THE FINAL VISIT, ABOUT 14 WEEKS
Change in Leg Blood Flow Values from Baseline
BASELINE TO THE END OF THE FINAL VISIT, ABOUT 14 WEEKS
Arm Vascular Function at Rest (Flow Mediated Dilation Test)
BASELINE TO THE END OF THE FINAL VISIT, ABOUT 14 WEEKS
Change in Brachial Artery Dilation from Baseline Values
BASELINE TO THE END OF THE FINAL VISIT, ABOUT 14 WEEKS
Arm Vascular Function in Response to Exercise (Handgrip Exercise Test)
BASELINE TO THE END OF THE FINAL VISIT, ABOUT 14 WEEKS
Change in Brachial Artery Dilation from Baseline Values
BASELINE TO THE END OF THE FINAL VISIT, ABOUT 14 WEEKS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get vascular diseases a year in the United States?

Over 2 million people develop a vascular disease each year; 523,000 cases required treatment and 1,450,000 lost a limb or partial, permanent loss of sensation in the lower extremities. Approximately 80,000 cases of stroke annually are due to heart disease.

Anonymous Patient Answer

What causes vascular diseases?

Although rare, vascular diseases, particularly peripheral artery disease, are often asymptomatic, and their treatment may affect the outcome if they become symptomatic. As the burden on healthcare resources increases with time from diagnosis onwards, it is important to identify and treat the condition as early as possible.

Anonymous Patient Answer

What is vascular diseases?

The two vascular diseases (arterial and venous) are the reasons that cause so many deaths worldwide every year. The major burden of these diseases occurs in people over the age of 60 and there are many different ways that one can prevent and treat them as the prevention of arterial disease is more effective than the prevention of venous disease.

Anonymous Patient Answer

Can vascular diseases be cured?

Most vascular diseases do not go away on their own. If you are diagnosed with stroke or limb-threatening artery stenosis or Occult Coronary Artery Disease (sic)(OCAD), then you will always feel short of breath. If you want to make things worse, [vigil therapy (vigilism)--the act of seeking to seek something to watch for]] might make it harder to get around. There are three ways to seek help for a diagnosed condition: through a healthcare provider or clinician, by the Internet, or through texts.

Anonymous Patient Answer

What are the signs of vascular diseases?

Vascular changes are noticeable in the retina and fundus of the optic vein, and the veins of the choroid may show signs of hemorrhage and calcification. A patient with a

Anonymous Patient Answer

What are common treatments for vascular diseases?

Vascular disease is treated with a variety of modalities including medications and procedures. Endovascular procedures including interventional radiology, interventional neuroradiology, endovascular surgery, interventional oncology and vascular critical care are the main modes of treatment.

Anonymous Patient Answer

What is the average age someone gets vascular diseases?

Vascular conditions can affect people of all ages and can have many different causes. If you think you may have a vascular disease, see a doctor or go to the websites listed from [Power] so you can find an amazing provider with specific expertise.\n

Anonymous Patient Answer

What are the common side effects of moderate intensity, high volume exercise training?

Moderate intensity training of 45 min daily can adversely affect mood, motivation and enjoyment of life, and may promote anxiety and/or distress. High volume training may be associated with an increase in body weight in males, increased systolic blood pressure and impaired heart function.

Anonymous Patient Answer

What is the latest research for vascular diseases?

Vascular disease is a leading cause of morbidity and mortality in industrialized nations. Although advancements have been made in the treatment of vascular disease with pharmacologic adjuncts and biologics, there's still a need for new research into the causes, pathophysiology, prediction and prevention of vascular disease and its complications. \nThe American College of Radiology (ACR) is offering free exams through its mobile app entitled: Mobile Diagnostic Imaging. The app is available as an iPhone, Android and Windows Phone app on the AppStore and Google Play Store.

Anonymous Patient Answer

What is moderate intensity, high volume exercise training?

Moderate-intensity endurance exercise training using a progressive exercise prescription of 10-40 min aerobic bouts per week produces clinically meaningful improvements in both cardiometabolic risk factors, physical fitness and performance. Exercise guidelines are based on energy expenditure and maximal oxygen consumption per minute. Exercise at 55% VO2max is [moderate] and exercise at 50% VO2max is [high] for training intensity regimes for cardio-protection.

Anonymous Patient Answer

Is moderate intensity, high volume exercise training typically used in combination with any other treatments?

There is low to very low quality of evidence supporting the use of moderate to high intensity, low volume exercise as an adjunct to other therapies to prevent the progression of atherosclerosis and reduce cardiovascular risk factors.

Anonymous Patient Answer
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