Etodolac

Postoperative Pain, Rheumatoid Arthritis, Muscle Spasms + 9 more

Treatment

3 FDA approvals

20 Active Studies for Etodolac

Treatment for

Postoperative Pain

What is Etodolac

EtodolacThe Generic name of this drug

Treatment SummaryEtodolac is a type of anti-inflammatory drug used to reduce pain, inflammation, and fever. It works by blocking the production of a type of chemical called prostaglandin and is typically prescribed to treat rheumatoid arthritis and osteoarthritis.

Lodineis the brand name

image of different drug pills on a surface

Etodolac Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lodine

Etodolac

1993

213

Approved as Treatment by the FDA

Etodolac, also known as Lodine, is approved by the FDA for 3 uses which include Osteoarthritis (OA) and Rheumatoid Arthritis .

Osteoarthritis (OA)

Rheumatoid Arthritis

Juvenile arthritis

Effectiveness

How Etodolac Affects PatientsEtodolac is a medication used to treat osteoarthritis, rheumatoid arthritis, and acute pain. It works by blocking the body's production of chemicals that cause fever, pain, swelling, and inflammation. Etodolac comes in two forms - the S-form, which is active, and the R-form, which is inactive. It is stable and neither form will turn into the other when taken by the body.

How Etodolac works in the bodyEtodolac is an anti-inflammatory drug that works by blocking the enzyme cyclooxygenase (COX). This stops the formation of inflammatory molecules, called prostaglandins, which can cause swelling and pain. Etodolac has a special ability to target COX-2 more than COX-1. It also works on the hypothalamus, a part of the brain, to reduce fever.

When to interrupt dosage

The advised measure of Etodolac is contingent upon the diagnosed state, including Acute Pain, Heartburn and Pain. The amount of dosage is also contingent upon the mode of delivery (e.g. Oral or Tablet, film coated) specified in the table beneath.

Condition

Dosage

Administration

gastrointestinal ulceration

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Collagen Diseases

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Heartburn

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Acute Pain

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Postoperative Pain

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Chronic Back Pain

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Pain

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Osteoarthritis (OA)

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Spinal Disorders

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Juvenile arthritis

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Rheumatoid Arthritis

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Muscle Spasms

, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Warnings

Etodolac has three prescribed contraindications, so it should not be taken when confronting circumstances in the table below.Etodolac Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Etodolac may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Etodolac may interact with Pulse Frequency

Coronary Artery Bypass Grafting

Do Not Combine

There are 20 known major drug interactions with Etodolac.

Common Etodolac Drug Interactions

Drug Name

Risk Level

Description

Macimorelin

Major

The therapeutic efficacy of Macimorelin can be decreased when used in combination with Etodolac.

Methotrexate

Major

The serum concentration of Methotrexate can be increased when it is combined with Etodolac.

Mifamurtide

Major

The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Etodolac.

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Etodolac is combined with Neomycin.

Omacetaxine mepesuccinate

Major

The risk or severity of bleeding can be increased when Etodolac is combined with Omacetaxine mepesuccinate.

Etodolac Toxicity & Overdose RiskTaking a selective COX-2 inhibitor may put some patients at risk of having a heart attack or stroke. Etodolac might also raise blood pressure and cause swelling and fluid retention. There is a risk of stomach issues such as bleeding, ulcers and holes in the stomach, as well as direct kidney injury. Severe skin reactions like exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported. Milder side effects may include abdominal pain, constipation, diarrhea, dyspepsia, flatulence, nausea, vomiting, dizziness, edema, liver problems

image of a doctor in a lab doing drug, clinical research

Etodolac Novel Uses: Which Conditions Have a Clinical Trial Featuring Etodolac?

129 active trials are being conducted to assess the capability of Etodolac in relieving Osteoarthritis (OA), spinal disorders and gastrointestinal ulceration.

Condition

Clinical Trials

Trial Phases

Chronic Back Pain

2 Actively Recruiting

Not Applicable

Heartburn

14 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1

Spinal Disorders

1 Actively Recruiting

Phase 3

Muscle Spasms

0 Actively Recruiting

gastrointestinal ulceration

0 Actively Recruiting

Pain

0 Actively Recruiting

Osteoarthritis (OA)

0 Actively Recruiting

Collagen Diseases

0 Actively Recruiting

Acute Pain

21 Actively Recruiting

Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 1

Rheumatoid Arthritis

61 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Juvenile arthritis

15 Actively Recruiting

Phase 2, Phase 3, Phase 1, Not Applicable

Postoperative Pain

21 Actively Recruiting

Phase 4, Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2

Etodolac Reviews: What are patients saying about Etodolac?

5Patient Review

7/27/2020

Etodolac for Pain

This treatment has been a lifesaver for me. I was in severe pain for months, and finally got some relief after being prescribed etodolac. Within days, I was feeling much better, and now after two weeks, I'm back to normal. Thank you for this medication!

5Patient Review

2/14/2020

Etodolac for Joint Damage causing Pain and Loss of Function

This medication has been a game-changer for me. I was struggling with regular pain from a loss of meniscus and swelling in my left knee, but this treatment really helped to keep the swelling down and also eased some of the pressure I was feeling in my back from slipped discs. I would recommend giving it at least a month before you write it off--I'm sure you'll be pleasantly surprised with the results, as I was!

5Patient Review

1/19/2017

Etodolac for Pain

The medication has been effective, but I am worried about potential side effects.

5Patient Review

1/2/2015

Etodolac for Pain

5Patient Review

10/22/2015

Etodolac for Pain

It's been effective at managing my pain, but I worry about the potential side effects. I don't want to damage my stomach or create more problems by taking too much of it.

4.7Patient Review

4/16/2015

Etodolac for Rheumatoid Arthritis

I injured my lower back playing basketball and, despite MRIs coming up clean, nerve tests confirmed the issue. The pain was serious enough to radiate down my entire leg. It took many months to recover, but etodolac was by far the best of the many medications I tried. Muscle relaxers did next to nothing for me, and tramadol wasn't much better. This drug allowed me to get back to work, though.

4.7Patient Review

12/20/2017

Etodolac for Pain

I've been using this medication for over two decades to manage my chronic pain from fibromyalgia and osteoarthritis. Recently, I started having liver problems which could be related to the Lodine. It's hard to go without it because it is effective in managing my pain, but I don't want to risk further liver damage.

4.7Patient Review

10/30/2022

Etodolac for Pain

I've been running for years and my body is really feeling the effects. I have arthritis in multiple joints, and this is the only treatment that has given me relief. I took it as soon as I got it from the pharmacy and by the time I got home, I could already feel a difference.

4.3Patient Review

9/11/2015

Etodolac for Inflammation of the Tendon

I didn't really notice much of a difference when taking this medication.

3Patient Review

11/14/2017

Etodolac for Pain

I was prescribed this medication for my fibromyalgia. I've found that on days where my pain is tolerable, it's an effective medication; however, on days when my pain is more severe, this medication actually makes me feel worse. This is because I can't take BC Powder to help alleviate the pain. So basically, I'm stuck with more pain and no way to relieve it. Not worth it in my opinion.

3Patient Review

12/30/2018

Etodolac for Rheumatic Disease causing Pain & Stiffness in Backbone

While this treatment does help, it only takes the edge off. I've tried other medications that have been more effective. However, those come with the cost of increased nausea and bathroom trips.

2.7Patient Review

7/7/2015

Etodolac for Pain

This treatment cuts down on my pain significantly, though it doesn't completely eliminate it. I've been told to take two pills a day, but even that doesn't suffice; three pills is what I need to manage the discomfort. That being said, this works better for me than Clebrex, Mobic, and Valtarin.

2.7Patient Review

8/17/2015

Etodolac for Inflammation of the Tendon

These pills are quite expensive, and I didn't feel that they worked any better than ibuprofen for my joint/tendon pain. It took a few hours to even start feeling some relief from the pain, whereas ibuprofin kicks in much faster. Overall, not worth the price tag in my opinion.

2.3Patient Review

2/20/2019

Etodolac for Inflammation of the Sac Surrounding the Joint - Bursitis

I took this medication for two months with no change in the severity of my pain.

2.3Patient Review

11/19/2017

Etodolac for Inflammation of the Tendon

I tried Etodolac for my hip pain, which was diagnosed as tendonitis. It made me feel really nauseous, but it didn't relieve the pain any more than ibuprofen or aspirin. It was better than naproxin sodium, though.

2Patient Review

11/28/2016

Etodolac for Pain

I found this treatment to be ineffective. Ibuprofen worked better for me than this did.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about etodolac

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is etodolac used for?

"Etodolac is an NSAID used to relieve mild to moderate pain, including the symptoms of arthritis such as inflammation, swelling, stiffness, and joint pain."

Answered by AI

What are the side effects of etodolac?

"or watery eyes

The following are symptoms of an allergy: constipation, diarrhea, gas or bloating, vomiting, headache, dizziness, ringing in the ears, runny nose, or watery eyes."

Answered by AI

Is etodolac stronger than ibuprofen?

"A double-blind study comparing etodolac and ibuprofen was conducted with 1,446 patients with rheumatoid arthritis. The patients were given either 150 mg of etodolac twice daily, 500 mg of etodolac twice daily, or 600 mg of ibuprofen four times daily. The study found that both dosages of etodolac were similar in effectiveness to the ibuprofen dosage."

Answered by AI

Is etodolac the same as naproxen?

"Do etodolac and naproxen (Aleve) work in the same way? Both etodolac and naproxen (Aleve) are nonsteroidal anti-inflammatory drugs (NSAIDs) and they work by reducing pain and inflammation. Etodolac is only available with a prescription and naproxen (Aleve) is available with or without a prescription (over-the-counter)."

Answered by AI

Clinical Trials for Etodolac

Image of McMaster Children's Hospital, in Hamilton, Canada.

M3 for Children

Hamilton, Canada

"This trial will assess the effectiveness of a program called Making Mindfulness Matter (M3) for children with Juvenile arthritis and their parents. The program is an 8-week online intervention that combines mindfulness

Waitlist Available

McMaster Children's Hospital, (+2 Sites)Roberta Berard, MD

Image of Pelvic Health and Continence Specialties in Rochester, United States.

TENS for Stress Incontinence

This trial will involve women with stress urinary incontinence undergoing a bulking procedure. They will be randomly assigned to two groups: one group will receive electrical nerve stimulation for pain relief during the procedure,

Waitlist Available

Pelvic Health and Continence Specialties

Image of Foundation for Orthopaedic Research and Education in Tampa, United States.

Exparel for Back Pain

This trial aims to compare the effectiveness of two different pain management methods for patients undergoing a specific type of back surgery. The researchers believe that using a certain type of nerve block with Exparel will be

Waitlist Available

Foundation for Orthopaedic Research and EducationJohn Small, MDPacira Pharmaceuticals, Inc

Image of Hopital du Sacre-Coeur de Montreal in Montreal, Canada.

Vitamin C for Acute Pain

Montreal, Canada

"This trial aims to determine if vitamin C can reduce pain intensity in patients with acute musculoskeletal pain over a seven-day period following an emergency department visit. Participants will either receive vitamin C or a placebo

Waitlist Available

Dietary Supplement

Hopital du Sacre-Coeur de MontrealRaoul Daoust, MD MSc

Have you considered Etodolac clinical trials? We made a collection of clinical trials featuring Etodolac, we think they might fit your search criteria.

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Famotidine +1 More for Indigestion

Stony Brook, NY

This trial aims to compare the effectiveness of intravenous famotidine (an H2 receptor antagonist) and Maalox/Mylanta (an oral antacid) in treating dyspepsia in

Stony Brook University Hospital

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TENS unit for Pain relief

"This trial involves screening subjects over the phone or at a clinic to see if they can participate. If eligible and interested, they will sign a consent form and then be enrolled in the study. Patients can

Waitlist Available

Tufts Medical CenterAndrea Zuckerman, MD

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Vibroacoustic for Laryngeal Cancer

Charlottesville, VA

This trial is looking at the use of vibration and augmented reality (AR) as non-medication options to help patients tolerate in-office procedures better. These procedures are a safe and cost-effective alternative to operating

UVA Fontaine Research Park Building 415James J Daniero, MD

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MR-107A-02 for Acute Pain

This trial is being conducted to see if MR-107A-02 is effective and safe in treating acute pain after herniorrhaphy (surgery to repair a hernia).

Investigator site 210 (+12 Sites)Susanne VogtMylan Specialty, LP

Have you considered Etodolac clinical trials? We made a collection of clinical trials featuring Etodolac, we think they might fit your search criteria.

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SBT777101 for Rheumatoid Arthritis

This trial is testing a new treatment called SBT777101 for people with rheumatoid arthritis. The study will look at whether it is safe and how it affects the participants. The treatment will be

University of Colorado (+4 Sites)Mark Eisner, MDSonoma Biotherapeutics, Inc.

Image of Alberta Children's Hospital in Calgary, Canada.

Virtual Self-Management Program (SMP) for Juvenile Idiopathic Arthritis

Calgary, Canada

This trial aims to test a virtual self-management program for adolescents with JIA across different provinces. Participants will be divided into two groups - one group will participate in the program while the other group will receive

Alberta Children's Hospital

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EndoFLIP for Hiatal Hernia

Kingston, Canada

This trial looks at a new surgical instrument to help treat reflux & hiatal hernia patients. Measurements taken during surgery are compared to quality of life scores to assess effectiveness.

KHSCWiley Chung, MD MHPEMedtronic

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Intra-nasal Ketorolac for Stent-Related Pain in Kidney Stones

This trial compares two drugs to improve quality-of-life & reduce unplanned visits for patients with ureteral stents.

Waitlist Available

UT Southwestern Medical CenterBrett Johnson, MD

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