Etodolac

Postoperative Pain, Rheumatoid Arthritis, Spasm + 9 more
Treatment
5 FDA approvals
20 Active Studies for Etodolac

What is Etodolac

EtodolacThe Generic name of this drug
Treatment SummaryEtodolac is a type of anti-inflammatory drug used to reduce pain, inflammation, and fever. It works by blocking the production of a type of chemical called prostaglandin and is typically prescribed to treat rheumatoid arthritis and osteoarthritis.
Lodineis the brand name
image of different drug pills on a surface
Etodolac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lodine
Etodolac
1993
213

Approved as Treatment by the FDA

Etodolac, also known as Lodine, is approved by the FDA for 5 uses which include Osteoarthritis (OA) and Juvenile Idiopathic Arthritis (JIA) .
Osteoarthritis (OA)
Juvenile Idiopathic Arthritis (JIA)
Juvenile arthritis
Rheumatoid Arthritis
Osteoarthritis

Effectiveness

How Etodolac Affects PatientsEtodolac is a medication used to treat osteoarthritis, rheumatoid arthritis, and acute pain. It works by blocking the body's production of chemicals that cause fever, pain, swelling, and inflammation. Etodolac comes in two forms - the S-form, which is active, and the R-form, which is inactive. It is stable and neither form will turn into the other when taken by the body.
How Etodolac works in the bodyEtodolac is an anti-inflammatory drug that works by blocking the enzyme cyclooxygenase (COX). This stops the formation of inflammatory molecules, called prostaglandins, which can cause swelling and pain. Etodolac has a special ability to target COX-2 more than COX-1. It also works on the hypothalamus, a part of the brain, to reduce fever.

When to interrupt dosage

The advised measure of Etodolac is contingent upon the diagnosed state, including Acute Pain, Heartburn and Pain. The amount of dosage is also contingent upon the mode of delivery (e.g. Oral or Tablet, film coated) specified in the table beneath.
Condition
Dosage
Administration
Spinal Disorders
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Chronic Back Pain
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Collagen Diseases
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Postoperative Pain
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Spasm
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Juvenile arthritis
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Osteoarthritis
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Acute Pain
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Heartburn
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Stomach Ulcer
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Pain
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Rheumatoid Arthritis
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral

Warnings

Etodolac has three prescribed contraindications, so it should not be taken when confronting circumstances in the table below.Etodolac Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Etodolac may interact with Pulse Frequency
Coronary Artery Bypass Grafting
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Etodolac may interact with Pulse Frequency
There are 20 known major drug interactions with Etodolac.
Common Etodolac Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Etodolac.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Etodolac.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Etodolac.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Etodolac is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Etodolac is combined with Omacetaxine mepesuccinate.
Etodolac Toxicity & Overdose RiskTaking a selective COX-2 inhibitor may put some patients at risk of having a heart attack or stroke. Etodolac might also raise blood pressure and cause swelling and fluid retention. There is a risk of stomach issues such as bleeding, ulcers and holes in the stomach, as well as direct kidney injury. Severe skin reactions like exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported. Milder side effects may include abdominal pain, constipation, diarrhea, dyspepsia, flatulence, nausea, vomiting, dizziness, edema, liver problems
image of a doctor in a lab doing drug, clinical research

Etodolac Novel Uses: Which Conditions Have a Clinical Trial Featuring Etodolac?

129 active trials are being conducted to assess the capability of Etodolac in relieving Osteoarthritis (OA), spinal disorders and gastrointestinal ulceration.
Condition
Clinical Trials
Trial Phases
Postoperative Pain
21 Actively Recruiting
Phase 4, Phase 2, Phase 1, Not Applicable, Early Phase 1, Phase 3
Juvenile arthritis
9 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Acute Pain
1 Actively Recruiting
Not Applicable
Osteoarthritis
0 Actively Recruiting
Stomach Ulcer
0 Actively Recruiting
Collagen Diseases
0 Actively Recruiting
Heartburn
15 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1, Phase 4
Spasm
0 Actively Recruiting
Spinal Disorders
0 Actively Recruiting
Pain
0 Actively Recruiting
Rheumatoid Arthritis
58 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Chronic Back Pain
5 Actively Recruiting
Not Applicable

Etodolac Reviews: What are patients saying about Etodolac?

5Patient Review
7/27/2020
Etodolac for Pain
This treatment has been a lifesaver for me. I was in severe pain for months, and finally got some relief after being prescribed etodolac. Within days, I was feeling much better, and now after two weeks, I'm back to normal. Thank you for this medication!
5Patient Review
2/14/2020
Etodolac for Joint Damage causing Pain and Loss of Function
This medication has been a game-changer for me. I was struggling with regular pain from a loss of meniscus and swelling in my left knee, but this treatment really helped to keep the swelling down and also eased some of the pressure I was feeling in my back from slipped discs. I would recommend giving it at least a month before you write it off--I'm sure you'll be pleasantly surprised with the results, as I was!
5Patient Review
1/19/2017
Etodolac for Pain
The medication has been effective, but I am worried about potential side effects.
5Patient Review
1/2/2015
Etodolac for Pain
5Patient Review
10/22/2015
Etodolac for Pain
It's been effective at managing my pain, but I worry about the potential side effects. I don't want to damage my stomach or create more problems by taking too much of it.
4.7Patient Review
4/16/2015
Etodolac for Rheumatoid Arthritis
I injured my lower back playing basketball and, despite MRIs coming up clean, nerve tests confirmed the issue. The pain was serious enough to radiate down my entire leg. It took many months to recover, but etodolac was by far the best of the many medications I tried. Muscle relaxers did next to nothing for me, and tramadol wasn't much better. This drug allowed me to get back to work, though.
4.7Patient Review
12/20/2017
Etodolac for Pain
I've been using this medication for over two decades to manage my chronic pain from fibromyalgia and osteoarthritis. Recently, I started having liver problems which could be related to the Lodine. It's hard to go without it because it is effective in managing my pain, but I don't want to risk further liver damage.
4.7Patient Review
10/30/2022
Etodolac for Pain
I've been running for years and my body is really feeling the effects. I have arthritis in multiple joints, and this is the only treatment that has given me relief. I took it as soon as I got it from the pharmacy and by the time I got home, I could already feel a difference.
4.3Patient Review
9/11/2015
Etodolac for Inflammation of the Tendon
I didn't really notice much of a difference when taking this medication.
3Patient Review
11/14/2017
Etodolac for Pain
I was prescribed this medication for my fibromyalgia. I've found that on days where my pain is tolerable, it's an effective medication; however, on days when my pain is more severe, this medication actually makes me feel worse. This is because I can't take BC Powder to help alleviate the pain. So basically, I'm stuck with more pain and no way to relieve it. Not worth it in my opinion.
3Patient Review
12/30/2018
Etodolac for Rheumatic Disease causing Pain & Stiffness in Backbone
While this treatment does help, it only takes the edge off. I've tried other medications that have been more effective. However, those come with the cost of increased nausea and bathroom trips.
2.7Patient Review
7/7/2015
Etodolac for Pain
This treatment cuts down on my pain significantly, though it doesn't completely eliminate it. I've been told to take two pills a day, but even that doesn't suffice; three pills is what I need to manage the discomfort. That being said, this works better for me than Clebrex, Mobic, and Valtarin.
2.7Patient Review
8/17/2015
Etodolac for Inflammation of the Tendon
These pills are quite expensive, and I didn't feel that they worked any better than ibuprofen for my joint/tendon pain. It took a few hours to even start feeling some relief from the pain, whereas ibuprofin kicks in much faster. Overall, not worth the price tag in my opinion.
2.3Patient Review
2/20/2019
Etodolac for Inflammation of the Sac Surrounding the Joint - Bursitis
I took this medication for two months with no change in the severity of my pain.
2.3Patient Review
11/19/2017
Etodolac for Inflammation of the Tendon
I tried Etodolac for my hip pain, which was diagnosed as tendonitis. It made me feel really nauseous, but it didn't relieve the pain any more than ibuprofen or aspirin. It was better than naproxin sodium, though.
2Patient Review
11/28/2016
Etodolac for Pain
I found this treatment to be ineffective. Ibuprofen worked better for me than this did.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about etodolac

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is etodolac used for?

"Etodolac is an NSAID used to relieve mild to moderate pain, including the symptoms of arthritis such as inflammation, swelling, stiffness, and joint pain."

Answered by AI

What are the side effects of etodolac?

"or watery eyes

The following are symptoms of an allergy: constipation, diarrhea, gas or bloating, vomiting, headache, dizziness, ringing in the ears, runny nose, or watery eyes."

Answered by AI

Is etodolac stronger than ibuprofen?

"A double-blind study comparing etodolac and ibuprofen was conducted with 1,446 patients with rheumatoid arthritis. The patients were given either 150 mg of etodolac twice daily, 500 mg of etodolac twice daily, or 600 mg of ibuprofen four times daily. The study found that both dosages of etodolac were similar in effectiveness to the ibuprofen dosage."

Answered by AI

Is etodolac the same as naproxen?

"Do etodolac and naproxen (Aleve) work in the same way? Both etodolac and naproxen (Aleve) are nonsteroidal anti-inflammatory drugs (NSAIDs) and they work by reducing pain and inflammation. Etodolac is only available with a prescription and naproxen (Aleve) is available with or without a prescription (over-the-counter)."

Answered by AI

Clinical Trials for Etodolac

Image of California Clinical Trials Medical Group in Glendale, United States.

NTR-1011 for Lupus and Rheumatoid Arthritis

18 - 75
All Sexes
Glendale, CA
This phase 1a and 1b study is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of NTR-1011 in healthy adults and in adult patients with systemic lupus erythematosus and rheumatoid arthritis. The main goals of this study are to determine the safety profile of NTR-1011 across subcutaneous and intravenous dose levels, understand how the drug behaves in the body, characterize its biological activity through relevant pharmacodynamic markers, assess the potential for immune responses to treatment, and explore early signals of clinical benefit in autoimmune disease settings. This is a randomized, double blind, placebo controlled study that begins with a single ascending dose evaluation in healthy volunteers followed by a multiple dose assessment in patients. The design is intended to define the highest safe and well tolerated dose, establish a robust PK and PD baseline, and generate initial patient level evidence to support dose selection and advancement into subsequent clinical development.
Phase 1
Recruiting
California Clinical Trials Medical GroupHakop Gevorkyan, MDNeutrolis
Image of Weill Cornell Medical College in New York, United States.

Health Coaching for Rheumatoid Arthritis

18+
All Sexes
New York, NY
The goal of this clinical trial is to learn if peer coaching works to reduce levels of anxiety and/or depression in adults diagnosed with Rheumatoid Arthritis (RA). The main questions it aims to answer are: Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months from baseline? Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months compared to those in the control arm? Researchers will compare the peer coaching intervention to an active-control arm (where people without RA coach participants on general health and nutrition topics) to see if peer coaching works to reduce anxiety and/or depression. Participants will meet with a coach every week for 9 weeks and complete several surveys before, during and after the intervention
Recruiting
Has No Placebo
Weill Cornell Medical CollegeIris Y Navarro-Millán, MDBristol-Myers Squibb
Have you considered Etodolac clinical trials? We made a collection of clinical trials featuring Etodolac, we think they might fit your search criteria.Go to Trials
Image of Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016) in New York, United States.

Electromagnetic Resonance Therapy for Autoimmune Diseases

Any Age
All Sexes
New York, NY
The ImmuneNet study is a Phase I/II clinical trial sponsored by Truway Health, Inc. It will test whether gentle, low-frequency electromagnetic resonance (LF-EMR) can influence how immune cells communicate and synchronize with each other. The goal is to see if this "quantum-synaptic" signaling effect can help stabilize immune activity and reduce the number of autoimmune flare-ups in people living with conditions such as lupus, rheumatoid arthritis, or multiple sclerosis. Participants will receive either an active or a sham (placebo) LF-EMR session three times per week for twelve weeks. Each session is completely non-invasive. Blood samples will be collected to study cytokines (immune-system messenger molecules), gene-expression patterns, and electrical field coherence among immune cells. A machine-learning system will analyze these data to predict inflammation patterns and guide individualized treatment settings. All participant data will be securely recorded and time-stamped to ensure transparency and privacy. The expected outcome of the study is a measurable reduction in autoimmune flare frequency and symptom severity, along with improved understanding of how electromagnetic signaling might safely regulate immune function.
Phase 1 & 2
Waitlist Available
Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016)Gavin Solomon, President & CEOTruway Health, Inc.
Image of Washington University School of Medicine in St Louis, United States.

Pain Mechanisms for Juvenile Arthritis

9 - 17
All Sexes
St Louis, MO
Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disease in children. The main symptoms of JIA, which are often the primary focus of treatment, include joint swelling, stiffness, and tenderness. Additional symptoms can include malaise, fatigue, and pain. However, the exact mechanisms contributing to pain are not yet fully understood. Participants will complete a 2.5-hours study session. In the study session, psychophysical assessments of thermal and pressure stimuli will be performed. In addition, demographic, social, pubertal maturation, and behavioral and psychological factors will be collected via questionnaires. A saliva sample and/or blood draw may occur for the analysis of various immune factors and sex hormones. If a joint aspiration is done as part of their standard of care, we will request a sample of the synovial fluid for analyses of immune, hormonal and/or genetic factors. Participants will have the option to participate in additional optional follow-up study visits (every 3 months, up to 1 year) and to complete monthly surveys asking about their juvenile arthritis.
Recruiting
Has No Placebo
Washington University School of MedicineHadas Nahman-Averbuch, PhD
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Ketorolac for Infertility Treatment

18 - 37
Female
Iowa City, IA
Ketorolac is a medication often used to relieve pain after surgery. In the past, infertility doctors have been cautious about using ketorolac after egg retrieval for patients planning a fresh embryo transfer (usually done 5 days later). The concern was that ketorolac might increase the risk of bleeding or reduce the chances of the embryo implanting in the uterus. This concern comes from how ketorolac works-it blocks certain chemicals in the body (like prostaglandins and thromboxane) that help with blood clotting and play a role in early pregnancy. However, a large review of past studies found no real evidence that ketorolac increases bleeding risk. In fact, ketorolac is now routinely used for pain relief in IVF cycles where embryos are frozen and not transferred right away. More recent studies from Boston and Chapel Hill have shown that ketorolac provides better pain control and does not appear to harm IVF outcomes, even when embryos are transferred fresh (within the same cycle). Despite these encouraging findings, many IVF clinics still avoid using ketorolac during fresh cycles because of the theoretical concerns. That's why we need stronger, higher-quality research. This study aims to fill that gap by conducting a double-blind randomized controlled trial to find out whether giving ketorolac through an IV after egg retrieval affects important IVF outcomes-especially the chance of implantation and live birth-in patients undergoing fresh embryo transfers. Patients who choose to join the study will randomly be placed into one of two groups. One group will get ketorolac (a pain medicine) after an IVF egg retrieval. The other group will not get ketorolac after egg retrieval. Everything else in their IVF care will stay the same as it normally would. Primary outcome will be implantation rate following fresh embryo transfers in patients receiving ketorolac (30mg IV) vs no ketorolac for post-retrieval analgesia. Secondary outcomes will include pain scale, narcotics required, time to discharge, need for evaluation w/in 24 hours for pain/bleeding, clinical pregnancy rates, miscarriage rates, and live birth rates following fresh embryo transfers in patients receiving ketorolac vs no ketorolac for post-retrieval analgesia.
Phase 4
Recruiting
UI Health Care Center for Advanced Reproductive Care
Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA
Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.
Waitlist Available
Has No Placebo
University of California, Irvine - UCI Medical CenterJason Samarasena, MD, MBA
Have you considered Etodolac clinical trials? We made a collection of clinical trials featuring Etodolac, we think they might fit your search criteria.Go to Trials
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Physical Therapy for Ventral Hernia

18 - 75
All Sexes
Philadelphia, PA
The goal of this clinical trial is to evaluate the efficacy, safety, and cost-effectiveness of a tailored physical therapy (PT) intervention targeting Abdominal Core Health components in patients recovering from ventral hernia repair. The study focuses on patients aged 18-75 diagnosed with a ventral transverse hernia between 4 cm and 10 cm, scheduled for elective Ventral Hernia Repair (VHR). The main questions it aims to answer are: * Will tailored PT significantly improve abdominal core strength, biomechanical stability, and functional mobility compared to usual care at 3-months post-surgery? * Will tailored PT lead to higher patient-reported quality of life and satisfaction scores, with a lower incidence of post-operative complications such as bowel obstruction and pelvic floor dysfunction over a 1-year follow-up? * Will tailored PT result in decreased healthcare utilization, leading to overall cost savings or neutrality compared to usual care over the first year after VHR? Researchers will compare the tailored physical therapy group to a usual care group to see if the tailored intervention leads to significant improvements in clinical efficacy, patient outcomes, and cost-effectiveness. Participants will: * Be randomly assigned to either the Usual Care Group or the PT Group. * If in the Usual Care Group, receive standard post-operative instructions for 12 weeks, including guidance on binder use, safe lifting, and gradual return to activities. * If in the PT Group, receive foundational post-operative instructions for the first 2 weeks (similar to usual care). Undergo 6 structured and individualized PT sessions over 10 weeks if in the PT Group, with progression based on Oswestry Disability Index (ODI) and Pelvic Floor Distress Inventory-20 (PFDI-20) scores, including Symptom Modulation, Movement Control, Functional Optimization, or Impairment-Based interventions. Participants undergo data collection at 2 weeks, 12 weeks, and 1 year post-operation, including imaging, functional mobility tests, pain scales, patient-reported outcomes, physical measurements, and tracking of complications and healthcare utilization. Participate in semi-structured interviews after the 12-week assessment to provide qualitative insights into their experiences and perceived barriers/facilitators.
Waitlist Available
Has No Placebo
Thomas Jefferson UniversityChristopher Keating
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