Suzetrigine for Postoperative Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how well the medication suzetrigine manages pain after facial plastic surgery. The researchers aim to determine if suzetrigine can control pain, reduce opioid use, and improve recovery. It targets adults undergoing elective facial plastic surgery, where doctors plan to use suzetrigine for pain management. This study may suit those having this type of surgery and willing to try suzetrigine instead of opioids. As a Phase 4 trial, suzetrigine has already received FDA approval and proven effective, and this research seeks to understand its benefits for more patients.
Do I have to stop taking my current medications for the trial?
You may need to stop taking certain medications, especially if you are using strong CYP3A4 inhibitors like itraconazole or grapefruit juice, as these are not allowed in the trial.
What is the safety track record for suzetrigine?
Research has shown that suzetrigine is a safe option for managing post-surgical pain. The FDA has approved suzetrigine, a non-opioid medication, for treating moderate to severe pain, indicating trust in its safety for patients.
Studies have found that suzetrigine is well-tolerated and provides effective pain relief without the need for opioids, resulting in fewer side effects and a lower risk of addiction. A review of studies found that suzetrigine generally has a good safety record, with most people experiencing only mild or no side effects.
When considering participation in a trial for suzetrigine, current research supports its safety and highlights it as a promising alternative to traditional pain medications.12345Why are researchers enthusiastic about this study treatment?
Unlike the standard of care, which often relies on opioids for managing postoperative pain, Suzetrigine acts as an alternative pain management option without the dependency risks associated with opioids. Researchers are excited about Suzetrigine because it potentially offers effective pain relief without the side effects and addiction concerns linked to opioid use. This could revolutionize how postoperative pain is managed, making recovery safer and more comfortable for patients.
What is the effectiveness track record for suzetrigine in managing postoperative pain?
Research has shown that suzetrigine, which participants in this trial will receive, effectively manages post-surgical pain. In some studies, suzetrigine reduced pain by about 3 points on a pain scale within 48 hours after surgery, while a placebo reduced it by only 2 points. Other studies indicate that it provides good pain relief with fewer side effects than traditional opioid medications. Specifically, patients using suzetrigine reported significant pain improvement over 48 hours. This suggests that suzetrigine can be a reliable option for managing post-surgical pain, especially for those seeking to avoid opioids.678910
Who Is on the Research Team?
Deanna C. Menapace, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for adults over 18 who are having elective outpatient facial plastic surgery and can follow the study's procedures. They must be willing to use suzetrigine for pain after surgery. It's not open to pregnant or breastfeeding women, those allergic to suzetrigine, people under 18, women on hormonal birth control not counseled about suzetrigine, or anyone taking certain strong medications.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive suzetrigine for postoperative pain management instead of opioids
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Suzetrigine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor