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What is Edarbi
Azilsartan medoxomilThe Generic name of this drug
Treatment SummaryAzilsartan medoxomil is a type of drug commonly used to treat high blood pressure. This drug is usually taken as a pill and is available under the brand name Edarbi. It works by blocking a hormone in the body that causes blood vessels to tighten and narrow, which can raise blood pressure. Azilsartan medoxomil can be taken alone or along with other medications to help lower blood pressure and reduce the risk of cardiovascular events such as heart attack and stroke. It may also be used off-label to treat patients with a history of myocardial infarction or heart failure.
Edarbiis the brand name
Edarbi Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Edarbi
Azilsartan medoxomil
2011
10
Approved as Treatment by the FDA
Azilsartan medoxomil, otherwise known as Edarbi, is approved by the FDA for 2 uses including Hypertensive disease and inadequate response to monotherapy .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
inadequate response to monotherapy
Used to treat inadequate response to monotherapy in combination with Chlorthalidone
Effectiveness
How Edarbi Affects PatientsAzilsartan medoxomil is a drug that helps lower blood pressure by blocking the angiotensin II receptor. This decreases the amount of pressure on the blood vessels, leading to a lower blood pressure. The effects of this drug are seen within one hour of taking the drug, and can last up to 24 hours. Taking azilsartan medoxomil does not affect potassium or sodium levels, and it does not have any effect on the production of angiotensin II or bradykinin. There is no need to adjust the dosage based on sex, race, or other factors.
How Edarbi works in the bodyAzilsartan medoxomil helps regulate blood pressure by blocking the effects of a hormone called angiotensin II. Angiotensin II narrows blood vessels and increases the production of aldosterone, a hormone that helps the body retain water. Azilsartan medoxomil binds to AT1 receptors, blocking the effects of angiotensin II and reducing blood pressure. It is more effective than other similar drugs because it binds to AT1 receptors more strongly and stays attached for a longer period of time.
When to interrupt dosage
The advised dosage of Edarbi is reliant upon the specified condition, such as Hypertensive disorder, Atrial Fibrillation and Albuminuria. The dosage will be contingent on the method of delivery featured in the table hereafter.Condition
Dosage
Administration
Atrial Fibrillation
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral
Hypertensive disease
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral
Albuminuria
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral
Type 2 Diabetes
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral
inadequate response to monotherapy
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Edarbi ContraindicationsCondition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Anuria
Do Not Combine
Common Edarbi Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Azilsartan medoxomil may increase the hypotensive activities of Amifostine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Azilsartan medoxomil.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Azilsartan medoxomil.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Azilsartan medoxomil.
Sacubitril
Major
The risk or severity of angioedema can be increased when Azilsartan medoxomil is combined with Sacubitril.
Edarbi Toxicity & Overdose RiskThe maximum safe dose of azilsartan has not been determined yet. People have been able to tolerate doses of up to 320 mg per day, however. In the event of an overdose, supportive measures should be taken as azilsartan cannot be removed from the blood through dialysis. Azilsartan is also teratogenic, meaning it can cause birth defects in pregnant women, especially during the second and third trimesters.
Edarbi Novel Uses: Which Conditions Have a Clinical Trial Featuring Edarbi?
265 active trials are currently being conducted to investigate the potential of Edarbi to treat Atrial Fibrillation, inadequate response to monotherapy and Albuminuria.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
89 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Albuminuria
1 Actively Recruiting
Phase 4
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
inadequate response to monotherapy
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Edarbi Reviews: What are patients saying about Edarbi?
5Patient Review
12/22/2016 I switched to Edarbi from another blood pressure medication because of the side effects I was experiencing. It's been working really well for me at a lower dose, and my blood pressure has been great.
5Patient Review
6/9/2020 Out of the four different ARB drugs I was prescribed, Edarbi 40mgs is the only one that worked for me. My blood pressure has been constantly at 125/83, which is better than 140/96. Additionally, I experienced no negative side effects.
5Patient Review
11/7/2016 I was first given 40mg of this medication, and while my blood pressure did drop slightly, I am now on 80mg and feeling much better than before.
4.7Patient Review
12/11/2017 It lowered my blood pressure without any side effects for 3 years now.
4.3Patient Review
2/13/2019 I started taking Edarbi after being diagnosed with high blood pressure. My first dose was 40mg once a day, but after just two days my blood pressure crashed to 90/60. I stopped taking the pill and monitored my BP for seven days, which stayed below 140/90. Edarbi is a very strong medication, so I have had to quarter the pills to get 10mg per dose. At this lower dosage, I am able to maintain a normal BP of 120/80 both day and night.
Patient Q&A Section about edarbi
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the difference between Edarbi and losartan?
"Edarbi (azilsartan) lowers blood pressure and is more expensive than other medicines that work similarly. Cozaar (Losartan) lowers your blood pressure and protects kidney function like an ACE inhibitor, but with fewer side effects which lowers your risk for stroke and heart attack."
Answered by AI
What medication is similar to Edarbi?
"Edarbi is also used to treat kidney problems caused by type 2 diabetes.
The drugs Avapro and Edarbi are both angiotensin II receptor blockers (ARBs), which are used to treat hypertension (high blood pressure). In some cases, Avapro is prescribed alongside other blood pressure medications. Additionally, Avapro can also be used to ameliorate kidney problems that are caused by type 2 diabetes (non-insulin-dependent). Similarly, Edarbi is also effective in treating kidney problems resulting from type 2 diabetes."
Answered by AI
What's the side effects of Edarbi?
"The side effects of the medication include nausea, diarrhea, fatigue, cough, dizziness on standing, weakness or lack of energy, and feeling tired."
Answered by AI
Is Edarbi a good blood pressure medicine?
"You can take control of your high blood pressure by using EDARBI, an angiotensin II receptor blocker. EDARBI relaxes your blood vessels, which lowers your blood pressure."
Answered by AI
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