Edarbi

Atrial Fibrillation, Albuminuria, Type 2 Diabetes + 2 more
Treatment
2 FDA approvals
20 Active Studies for Edarbi

What is Edarbi

Azilsartan medoxomilThe Generic name of this drug
Treatment SummaryAzilsartan medoxomil is a type of drug commonly used to treat high blood pressure. This drug is usually taken as a pill and is available under the brand name Edarbi. It works by blocking a hormone in the body that causes blood vessels to tighten and narrow, which can raise blood pressure. Azilsartan medoxomil can be taken alone or along with other medications to help lower blood pressure and reduce the risk of cardiovascular events such as heart attack and stroke. It may also be used off-label to treat patients with a history of myocardial infarction or heart failure.
Edarbiis the brand name
image of different drug pills on a surface
Edarbi Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Edarbi
Azilsartan medoxomil
2011
10

Approved as Treatment by the FDA

Azilsartan medoxomil, otherwise known as Edarbi, is approved by the FDA for 2 uses including inadequate response to monotherapy and Hypertensive disease .
inadequate response to monotherapy
Used to treat inadequate response to monotherapy in combination with Chlorthalidone
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Edarbi Affects PatientsAzilsartan medoxomil is a drug that helps lower blood pressure by blocking the angiotensin II receptor. This decreases the amount of pressure on the blood vessels, leading to a lower blood pressure. The effects of this drug are seen within one hour of taking the drug, and can last up to 24 hours. Taking azilsartan medoxomil does not affect potassium or sodium levels, and it does not have any effect on the production of angiotensin II or bradykinin. There is no need to adjust the dosage based on sex, race, or other factors.
How Edarbi works in the bodyAzilsartan medoxomil helps regulate blood pressure by blocking the effects of a hormone called angiotensin II. Angiotensin II narrows blood vessels and increases the production of aldosterone, a hormone that helps the body retain water. Azilsartan medoxomil binds to AT1 receptors, blocking the effects of angiotensin II and reducing blood pressure. It is more effective than other similar drugs because it binds to AT1 receptors more strongly and stays attached for a longer period of time.

When to interrupt dosage

The advised dosage of Edarbi is reliant upon the specified condition, such as Hypertensive disorder, Atrial Fibrillation and Albuminuria. The dosage will be contingent on the method of delivery featured in the table hereafter.
Condition
Dosage
Administration
Atrial Fibrillation
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral
Hypertensive disease
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral
Albuminuria
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral
inadequate response to monotherapy
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral
Type 2 Diabetes
40.0 mg, , 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Edarbi Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Anuria
Do Not Combine
There are 20 known major drug interactions with Edarbi.
Common Edarbi Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Azilsartan medoxomil may increase the hypotensive activities of Amifostine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Azilsartan medoxomil.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Azilsartan medoxomil.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Azilsartan medoxomil.
Sacubitril
Major
The risk or severity of angioedema can be increased when Azilsartan medoxomil is combined with Sacubitril.
Edarbi Toxicity & Overdose RiskThe maximum safe dose of azilsartan has not been determined yet. People have been able to tolerate doses of up to 320 mg per day, however. In the event of an overdose, supportive measures should be taken as azilsartan cannot be removed from the blood through dialysis. Azilsartan is also teratogenic, meaning it can cause birth defects in pregnant women, especially during the second and third trimesters.
image of a doctor in a lab doing drug, clinical research

Edarbi Novel Uses: Which Conditions Have a Clinical Trial Featuring Edarbi?

265 active trials are currently being conducted to investigate the potential of Edarbi to treat Atrial Fibrillation, inadequate response to monotherapy and Albuminuria.
Condition
Clinical Trials
Trial Phases
inadequate response to monotherapy
0 Actively Recruiting
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Type 2 Diabetes
92 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Albuminuria
4 Actively Recruiting
Phase 3, Phase 4, Phase 2
Atrial Fibrillation
151 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1

Edarbi Reviews: What are patients saying about Edarbi?

5Patient Review
12/22/2016
Edarbi for High Blood Pressure
I switched to Edarbi from another blood pressure medication because of the side effects I was experiencing. It's been working really well for me at a lower dose, and my blood pressure has been great.
5Patient Review
6/9/2020
Edarbi for High Blood Pressure
Out of the four different ARB drugs I was prescribed, Edarbi 40mgs is the only one that worked for me. My blood pressure has been constantly at 125/83, which is better than 140/96. Additionally, I experienced no negative side effects.
5Patient Review
11/7/2016
Edarbi for High Blood Pressure
I was first given 40mg of this medication, and while my blood pressure did drop slightly, I am now on 80mg and feeling much better than before.
4.7Patient Review
12/11/2017
Edarbi for High Blood Pressure
It lowered my blood pressure without any side effects for 3 years now.
4.3Patient Review
2/13/2019
Edarbi for High Blood Pressure
I started taking Edarbi after being diagnosed with high blood pressure. My first dose was 40mg once a day, but after just two days my blood pressure crashed to 90/60. I stopped taking the pill and monitored my BP for seven days, which stayed below 140/90. Edarbi is a very strong medication, so I have had to quarter the pills to get 10mg per dose. At this lower dosage, I am able to maintain a normal BP of 120/80 both day and night.
4.3Patient Review
5/27/2021
Edarbi for High Blood Pressure
I've been taking Edarbyclor for three months now. While it's helped with the muscle spasms, the gastrointestinal symptoms are really bad. I get nauseous, have diarrhea, and experience a lot of bloating. I'm hoping that it's just something in my diet that can be easily controlled, but we'll see.
3.7Patient Review
12/16/2018
Edarbi for High Blood Pressure
I've been on Edarbi for two weeks now. It does lower my blood pressure, but I experience dizziness if I stand up too quickly or bend over.
3Patient Review
4/17/2019
Edarbi for High Blood Pressure
I'm not a fan of this drug because it gives me heart flutters. I'm anxious about the abnormal rhythms it's been causing, so I've scheduled an appointment with my doctor. Fingers crossed that they'll put me back on something else.
3Patient Review
7/15/2022
Edarbi for High Blood Pressure
The side effects were pretty harsh: fatigue, stomach bloating, wheezing, depression and respiratory congestion.
3Patient Review
9/30/2016
Edarbi for High Blood Pressure
This treatment does well in controlling my blood pressure, but I've been having a lot of back pain and sometimes an odd taste in my mouth.
2.7Patient Review
6/1/2016
Edarbi for High Blood Pressure
Didn't help my blood pressure as much as I needed, and caused other problems like fatigue and leg cramps. The eczema was the worst part, though.
2.3Patient Review
5/3/2016
Edarbi for High Blood Pressure
Nausea, awful taste in mouth, and feeling like a zombie are just some of the side effects I experienced. The pill did work, but it's not worth how I felt afterwards.
2.3Patient Review
2/10/2016
Edarbi for High Blood Pressure
I started taking Edarbi a few days ago because I'd gained weight from my previous medication. However, after only five days on Edarbi I've already gained three pounds and have been in severe pain on my right side and lower back. The pain has been preventing me from sleeping, so I'm going to call the doctor today and stop taking the drug.
1Patient Review
10/24/2018
Edarbi for High Blood Pressure
The leg pain was unbearable, and I constantly felt nauseous. We increased the dosage from 40mg to 80mg, but it still didn't lower my blood pressure effectively. In fact, I gained eight pounds in six weeks while taking this medication.
1Patient Review
2/12/2017
Edarbi for High Blood Pressure
I was on this treatment for a little over two weeks. It lowered my blood pressure to the point of dehydration and caused muscle cramps. I overall felt very dizzy and lightheaded while taking it and did not feel good at all. I decided to switch to a different drug.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about edarbi

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between Edarbi and losartan?

"Edarbi (azilsartan) lowers blood pressure and is more expensive than other medicines that work similarly. Cozaar (Losartan) lowers your blood pressure and protects kidney function like an ACE inhibitor, but with fewer side effects which lowers your risk for stroke and heart attack."

Answered by AI

What medication is similar to Edarbi?

"Edarbi is also used to treat kidney problems caused by type 2 diabetes.

The drugs Avapro and Edarbi are both angiotensin II receptor blockers (ARBs), which are used to treat hypertension (high blood pressure). In some cases, Avapro is prescribed alongside other blood pressure medications. Additionally, Avapro can also be used to ameliorate kidney problems that are caused by type 2 diabetes (non-insulin-dependent). Similarly, Edarbi is also effective in treating kidney problems resulting from type 2 diabetes."

Answered by AI

What's the side effects of Edarbi?

"The side effects of the medication include nausea, diarrhea, fatigue, cough, dizziness on standing, weakness or lack of energy, and feeling tired."

Answered by AI

Is Edarbi a good blood pressure medicine?

"You can take control of your high blood pressure by using EDARBI, an angiotensin II receptor blocker. EDARBI relaxes your blood vessels, which lowers your blood pressure."

Answered by AI

Clinical Trials for Edarbi

Have you considered Edarbi clinical trials? We made a collection of clinical trials featuring Edarbi, we think they might fit your search criteria.
Have you considered Edarbi clinical trials? We made a collection of clinical trials featuring Edarbi, we think they might fit your search criteria.
Have you considered Edarbi clinical trials? We made a collection of clinical trials featuring Edarbi, we think they might fit your search criteria.