Your session is about to expire
What is Dynacirc
IsradipineThe Generic name of this drug
Treatment SummaryIsradipine is a type of calcium channel blocker used to treat high blood pressure. It belongs to the dihydropyridine (DHP) class of calcium channel blockers, which are the most commonly prescribed. Isradipine specifically works by binding to calcium channels on the walls of arteries and reducing the flow of calcium into the cells. It is more effective on arterial cells than other types of cells, making it a good option for treating mild to moderate hypertension.
DynaCircis the brand name
Dynacirc Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
DynaCirc
Isradipine
1998
24
Approved as Treatment by the FDA
Isradipine, also known as DynaCirc, is approved by the FDA for 1 uses including Hypertensive disease .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Dynacirc Affects PatientsIsradipine keeps blood vessels from narrowing by preventing calcium from entering the cells in those vessels. This stops the cells from tightening, which helps keep the blood vessels open and decreases overall blood pressure.
How Dynacirc works in the bodyIsradipine is a type of medication called a calcium channel blocker. It works by targeting a type of calcium channel that is found in muscles, called an L-type calcium channel. Isradipine binds to the channel, keeping it in its inactive state and preventing it from sending signals to make muscles contract. This is especially useful for smooth muscles, as they take longer to contract than cardiac muscles. Isradipine also has an added advantage of being more selective for arterial smooth muscle cells than other types of calcium channel blockers, meaning it has less of an effect on the heart.
When to interrupt dosage
The advised dosage of Dynacirc is contingent on the specified condition. The quantity of dosage fluctuates, in line with the method of administration outlined in the table below.Condition
Dosage
Administration
Hypertensive disease
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Capsule, Capsule - Oral, Tablet - Oral, Tablet, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release
Warnings
There are 20 known major drug interactions with Dynacirc.Common Dynacirc Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Isradipine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Isradipine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Isradipine.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Isradipine.
Amifostine
Major
Isradipine may increase the hypotensive activities of Amifostine.
Dynacirc Toxicity & Overdose RiskOverdosing on Isradipine may cause fatigue, fast heart rate, and low blood pressure. In mice, a fatal dose is 200mg/kg, while in rabbits it is 50mg/kg. Rats can tolerate doses of over 2000mg/kg without any life-threatening effects.
Dynacirc Novel Uses: Which Conditions Have a Clinical Trial Featuring Dynacirc?
18 active clinical trials are in process to assess the potential of Dynacirc in the management of Hypertensive diseases.Condition
Clinical Trials
Trial Phases
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Dynacirc Reviews: What are patients saying about Dynacirc?
5Patient Review
5/3/2008 This medication helped to lower my blood pressure, but I started having sinus infections with pain and pressure. This wasn't a listed side effect on the information sheet that came with the medication, so I was surprised when it happened.
5Patient Review
2/3/2009 This medication was able to lower my blood pressure in a way that beta-blockers could not. Unfortunately, I have experienced constipation and nightmares as side effects. The latter is something I also dealt with while taking Norvasc, but it's still an issue even now.
5Patient Review
2/4/2009 I don't understand why this drug was taken off the market. It's a great treatment and it really helped me.
4Patient Review
7/23/2010 This medication was very effective in lowering my blood pressure. Out of the five different medications I've tried, this one had the best results with the least amount of side effects.
4Patient Review
7/23/2010 This medication is effective in lowering blood pressure, but I have experienced some negative side effects including swelling of my extremities and tingling sensations up my legs.
3.3Patient Review
5/6/2008 Dynacirc has been great for keeping my blood pressure in check. I tried six other medications before this one, and all of them resulted in some sort of negative side effect for me. Dynacirc is the only one that hasn't caused any problems, though I do miss grapefruit juice!
3Patient Review
2/1/2011 This drug is effective. I'm grateful for modern medicine.
3Patient Review
2/4/2011 This drug is great. It really helped me out.
3Patient Review
2/3/2011 This drug is effective. I'm grateful for modern medicine.
3Patient Review
2/3/2011 This drug is great. It really helped me out.
3Patient Review
2/1/2011 This drug is effective. I'm grateful for modern medicine.
3Patient Review
2/16/2011 I didn't have a great experience with this drug. I found it made me more spaced out and depressed, and I still experienced muscle, back, and joint pain.
3Patient Review
2/4/2011 This drug is effective. I'm grateful for modern medicine.
3Patient Review
2/4/2011 This drug is great. It really helped me out.
2.3Patient Review
1/18/2008Patient Q&A Section about dynacirc
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is DynaCirc used for?
"Isradipine is a calcium channel blocker that is used to treat hypertension (high blood pressure). Isradipine is sometimes used together with a diuretic or "water pill.""
Answered by AI
What type of drug is isradipine?
"Isradipine is a drug that works by blocking calcium channels. This affects the movement of calcium into cells, which in turn affects the functioning of the heart and blood vessels."
Answered by AI
What are the side effects of isradipine?
"If you experience any of the following symptoms, you should consult a doctor: headache, dizziness or lightheadedness, flushing, fast heartbeat, excessive tiredness, upset stomach, vomiting, diarrhea."
Answered by AI
What is the brand name for isradipine?
"Isradipine is a medication used to treat high blood pressure. It belongs to a class of drugs called calcium channel blockers and is typically prescribed to help reduce the risk of stroke and heart attack."
Answered by AI