Dextrose 50%

Hypokalemia, Terminal state, Hypokalemia + 26 more

Treatment

2 FDA approvals

20 Active Studies for Dextrose 50%

Treatment for

Hypokalemia

What is Dextrose 50%

Potassium chloride

The Generic name of this drug

Treatment Summary

Glucose is a type of sugar found naturally in plants, and produced in humans by the breakdown of carbohydrates. It circulates in the bloodstream and provides energy for cells through respiration and fermentation. Glucose is stored in plants as starch and in animals as glycogen. The most common form of glucose is D-glucose, and the synthetic form L-glucose is used as a low-calorie sweetener and laxative. Glucose can also be injected to provide nutritional supplementation or to help regulate glucose levels in people with metabolic disorders. It is an essential medicine that is used worldwide.

Thermotabs Buffered Salt Supplement

is the brand name

Dextrose 50% Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Thermotabs Buffered Salt Supplement

Potassium chloride

1937

841

Approved as Treatment by the FDA

Potassium chloride, otherwise called Thermotabs Buffered Salt Supplement, is approved by the FDA for 2 uses such as Hypokalemia and Hypokalemia .

Hypokalemia

Effectiveness

How Dextrose 50% Affects Patients

Glucose is an important source of energy in the body, as it is used for various cellular activities and also tells other molecules and proteins when to start working. When glucose is used, it is changed into carbon dioxide, water, and energy molecules. Glucose can also be converted and stored as fat, or stored in the liver and muscles as glycogen. Depending on the needs of the body, glucose stores can be released in a controlled way. Taking oral glucose tablets or injections can increase the amount of glucose in the body and can trigger the release of insulin from the gut.

How Dextrose 50% works in the body

Glucose is a major energy source for the body. It works by going through a series of steps called glycolysis, which breaks it down into smaller molecules and produces ATP and NADH molecules to provide energy. When one glucose molecule is processed, it can create up to 36 ATP molecules. Glucose can also be used to make other molecules like vitamin C, and it helps to regulate energy levels in the body. It does this by controlling how much glucose gets taken up in cells, and how the body processes it.

When to interrupt dosage

The suggested measure of Dextrose 50% is contingent upon the determined affliction, including Rehydration, Electrolyte replacement and Blood Specimen Collection. The amount likewise fluctuates per the technique of delivery (e.g. Hemodialysis or Solution) featured in the table beneath.

Condition

Dosage

Administration

Sudden Cardiac Arrest

0.75 mg/mL, , 150.0 mg/mL, 300.0 mg/mL, 1500.0 mg, 1875.0 mg, 750.0 mg, 600.0 mg, 1125.0 mg, 149.0 mg/mL, 0.3 mg/mL, 0.37 mg/mL, 3.0 mg/mL, 1.5 mg/mL, 2.97 mg/mL, 100.0 mg/mL, 0.1 meq/mL, 0.2 meq/mL, 0.3 meq/mL, 0.4 meq/mL, 1.49 mg/mL, 2.0 meq/mL, 4.0 meq/mL, 1.5 mg/mg, 1250.0 mg, 10.0 meq, 8.0 meq, 20.0 meq, 1.48 mg/mL, 0.0297 mg/mg, 0.0148 mg/mg, 0.0298 mg/mg, 0.754 mg/mL, 0.74 mg/mL, 25.0 meq, 99.0 mg, 10.0 %, 6200.0 mg, 500.0 mg, 7650.0 mg, 15260.0 mg, 13000.0 mg, 12500.0 mg, 25000.0 mg, 900.0 mg, 0.075 %, 760.0 mg, 2970.0 mg, 3050.0 mg, 190.0 mg, 740.0 mg, 0.12 %, 2.98 mg/mL, 2.82 mg/mL, 0.4 mg/mL, 14.9 mg/mL, 22.4 mg/mL, 7.46 mg/mL, 29.8 mg/mL, 1.193 mg/mL, 2.2 mg/mL, 157.0 mg, 149.1 mg/mL, 1.0 mg/mL, 50.0 mg, 21.0 mg, 0.02 meq/mg, 1.3 mg/mL, 1.41 mg/mL, 2.24 mg/mL, 3280.0 mg/mL, 0.745 mg/mL, 1.79 mg/mL, 0.0001 mg/mg, 20.0 mg, 0.0002 mg/mg, 34.0 mg, 7.5 mg, 1.015 mg/mL, 0.224 mg/mL, 1.875 mg/mg, 0.314 mg/mL, 0.157 mg/mL, 0.395 mg/mL, 4.87 mg/mL, 0.97 mg/mL, 0.746 mg/mL, 1000.0 mg, 2.05 mg/mL, 1.3 meq/mL, 75.0 mg/mL, 2.6 meq/mL, 1.11 mg/mL, 1.74 mg/mL, 1.19 mg/mL, 4.92 mg/mL, 125.0 mg/mL, 1015.0 mg, 0.004 meq/mL, 0.002 meq/mL, 3.28 mg/mL, 0.7 %, 0.038 %, 72.0 mg, 30.0 mg, 5.0 mg, 27.2 mg, 2.3 mg/mL, 2200.0 mg, 1200.0 mg, 1.4 mg/mL, 2250.0 mg, 24.5 mg, 7.45 mg/mL, 0.01 mg/mg, 0.375 mg/mL, 0.45 mg/mL, 250.0 mg/mL, 246.0 mg/mL, 3.355 mg/mL, 6.7 mg/mL, 10.1 mg/mL, 10.0 mg/mL, 5.02 mg/mL, 2.746 mg/mL, 3.35 mg/mL, 5.032 mg/mL, 6.71 mg/mL, 4.12 mg/mL, 8.39 mg/mL, 5.49 mg/mL, 0.398 mg/mL, 8.24 mg/mL, 2.75 mg/mL, 2.384 mg/mL, 3.36 mg/mL, 251.6 mg/mL, 1.784 mg/mL, 5.491 mg/mL, 0.38 mg/mL, 0.23468 mg/mg, 2.609 mg/mL, 10.06 mg/mL, 0.199 mg/mL, 200.0 mg/mL, 13.47 mg/mL, 10.05 mg/mL, 2.68 mg/mL, 1.86 mg/mg, 0.298 mg/mL, 7.828 mg/mL, 5.4914 mg/mL, 0.149 mg/mL, 5.03 mg/mL, 8.237 mg/mL, 8.387 mg/mL, 44.7 mg/mL, 4.119 mg/mL, 13.42 mg/mL, 2.63 mg/mL, 2.61 mg/mL, 0.15 mg/mL, 10.064 mg/mL, 0.075 mg/mL, 3.914 mg/mL, 1.2 mg/mL, 6.6 mg/mL, 11.74 mg/mL, 5.22 mg/mL, 74.55 mg/mL, 8.2 mg/mL, 0.01065 mg/mg, 5.5 mg/mL, 0.6245 mg/mL, 5.219 mg/mL, 0.76 mg/mL, 10.98 mg/mL, 3.4 mg/mL, 7.8278 mg/mL, 2.6093 mg/mL, 37.3 mg/mL, 8.38 mg/mL, 0.0304 mg/mg, 185.8 mg/mL, 74.6 mg/mL, 0.01 mmol/mL, 5.2185 mg/mL, 0.001 meq/mL, 1.57 mg/mL, 3.14 mg/mL, 2.74 mg/mL, 59.6 mg/mL, 5.2 mg/mL, 0.03 mg/mg, 2.39 mg/mL, 1.0 meq/mL, 37.5 mg, 13.0 mg, 5.5 mg, 71.5 mg, 0.055 mg/mg, 0.065 mg/mg, 55.0 mg, 105.0 mg, 15.0 mg, 57.2 mg, 0.5 mg, 35.0 mg, 12.5 mg, 25.0 mg, 200.0 mg, 75.0 mg, 0.02 mmol/mL, 80.0 mg

Solution - Ophthalmic, Ophthalmic, , Solution, Solution - Oral, Oral, Powder, for solution - Oral, Tablet, extended release, Tablet, film coated, extended release, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Powder, for solution, Tablet, film coated, extended release - Oral, Parenteral, Injection, solution, concentrate, Irrigant, Irrigation, Irrigant - Irrigation, Injection, solution, concentrate - Parenteral, Solution - Irrigation, Injection, solution - Intravenous, Intravenous, Solution - Intravenous, Injection, solution, Injection, Injection - Intravenous, Liquid, Liquid - Oral, Injection, solution, concentrate - Intravenous, Tablet, effervescent, Capsule - Oral, Tablet, effervescent - Oral, Capsule, Powder, for solution - Nasogastric; Oral, Nasogastric; Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Liquid - Hemodialysis, Hemodialysis, Liquid - Intravenous, Liquid - Irrigation, Powder - Hemodialysis, Solution - Intraocular, Intra-arterial, Intraocular, Solution - Intra-arterial, Kit; Powder, for solution; Tablet, delayed release - Oral, Solution - Intrathecal, Intrathecal, Solution - Hemodialysis, Kit; Powder, for solution; Tablet, delayed release, Granule, effervescent, Granule, effervescent - Oral, Liquid - Intraocular, Aerosol, Aerosol - Oral, Nasogastric, Powder, for solution - Nasogastric, Spray, Liquid - Buccal, Spray - Buccal, Buccal, Hemodialysis; Intravenous, Solution - Hemodialysis; Intravenous, Injection, solution - Intra-arterial, Emulsion - Topical, Kit - Oral, Kit, Patch, Topical, Patch - Topical, Emulsion, Solution - Extracorporeal, Injection - Intrathecal, Extracorporeal, Solution, for slush - Irrigation, Solution, for slush, Injection, emulsion - Intravenous, Injection, emulsion, For solution - Oral, For solution, Kit; Solution - Intraocular, Douche - Vaginal, Kit; Solution, Douche, Kit; Solution - Intraocular; Irrigation, Vaginal, Emulsion - Intravenous, Intraocular; Irrigation, Powder, for solution - Intraocular, Liquid - Ophthalmic, Injection, solution - Irrigation, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Acid- Base Balance

Rehydration

Anorexia

fluid and electrolyte maintenance therapy

Hypotonic Dehydration

Bowel preparation therapy

Parenteral Nutrition

Plasma Volume Replacement

hypodermoclysis

Hypokalemia

eye surgery

Hypokalemia

Hypovolemia

Urine alkalinization therapy

Fluid replacement therapy

Colonoscopy

Xerostomia

Isotonic Dehydration

Edema

Warnings

Dextrose 50% Contraindications

Condition

Risk Level

Notes

inhibited gastrointestinal capsule passage

Do Not Combine

Disease

Do Not Combine

Hyperkalemia

Do Not Combine

There are 20 known major drug interactions with Dextrose 50%.

Common Dextrose 50% Drug Interactions

Drug Name

Risk Level

Description

Amiloride

Major

The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Amiloride.

Canrenoic acid

Major

The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Canrenoic acid.

Canrenone

Major

The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Canrenone.

Eplerenone

Major

The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Eplerenone.

Spironolactone

Major

The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Spironolactone.

Dextrose 50% Toxicity & Overdose Risk

The lowest toxic dose of the drug for rats is 25800mg/kg. Taking too much of the drug can lead to dehydration, fluid accumulation, and allergic reactions. Severe allergic reactions may occur if the drug is taken orally or given intravenously.

Dextrose 50% Novel Uses: Which Conditions Have a Clinical Trial Featuring Dextrose 50%?

79 active trials are currently being conducted to assess the efficacy of Dextrose 50% in treating Heart Attack, Plasmapheresis and Post-Heart Surgery.

Condition

Clinical Trials

Trial Phases

Hypovolemia

0 Actively Recruiting

Bowel preparation therapy

1 Actively Recruiting

Phase 1, Phase 2

Electrolyte replacement

0 Actively Recruiting

Haemofiltration

0 Actively Recruiting

Hypokalemia

0 Actively Recruiting

Hypotonic Dehydration

0 Actively Recruiting

Hemodialysis

13 Actively Recruiting

Not Applicable, Phase 2

Terminal state

0 Actively Recruiting

Acid- Base Balance

0 Actively Recruiting

Fluid replacement therapy

0 Actively Recruiting

Hypokalemia

0 Actively Recruiting

Urine alkalinization therapy

0 Actively Recruiting

Rehydration

0 Actively Recruiting

Xerostomia

0 Actively Recruiting

Parenteral Nutrition

0 Actively Recruiting

Sudden Cardiac Arrest

5 Actively Recruiting

Not Applicable

Plasma Volume Replacement

0 Actively Recruiting

eye surgery

0 Actively Recruiting

Colonoscopy

3 Actively Recruiting

Not Applicable

Open Heart Surgery

1 Actively Recruiting

Phase 1, Phase 2

Patient Q&A Section about dextrose 50%

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is dextrose used to treat?

"The dextrose is given in order to raise the blood sugar levels, while the insulin is treating the elevated potassium. People with diabetes or hypoglycemia (chronically low blood sugar) may carry dextrose gel or tablets in case their blood sugar gets too low."

Answered by AI

Can dextrose 50 be given orally?

"Dextrose, also known as D-glucose, is a sugar that is used as a medication. It is given either by mouth or by injection, and is used to treat very low blood sugar (hypoglycemia), most often in people with diabetes mellitus."

Answered by AI

What does the in 50% dextrose mean?

"This is a sterile, nonpyrogenic, hypertonic solution of dextrose in water for injection, designed to be used as a fluid and nutrient replenisher. Each mL of fluid contains 0.5 g dextrose, hydrous, providing 3.4 kcal/gram."

Answered by AI