Daliresp

Chronic Obstructive Pulmonary Disease
Treatment
1 FDA approval
20 Active Studies for Daliresp

What is Daliresp

RoflumilastThe Generic name of this drug
Treatment SummaryRoflumilast is a drug used to treat chronic obstructive pulmonary disease (COPD) that works by blocking the enzyme phosphodiesterase-4 (PDE-4) in lung cells. Taking this medication may lead to an increase in psychiatric side effects, such as suicidal thoughts and attempts.
Dalirespis the brand name
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Daliresp Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Daliresp
Roflumilast
2011
16

Approved as Treatment by the FDA

Roflumilast, otherwise called Daliresp, is approved by the FDA for 1 uses including Chronic Obstructive Pulmonary Disease .
Chronic Obstructive Pulmonary Disease
Helps manage Chronic Obstructive Pulmonary Disease (COPD)

Effectiveness

How Daliresp Affects PatientsRoflumilast and its active metabolite, roflumilast N-oxide, work by blocking a certain enzyme (PDE4) from doing its job. This causes an increase in a chemical called cAMP that can help with certain cell functions. These drugs are very specific and only block PDE4, with no effect on other enzymes.
How Daliresp works in the bodyRoflumilast helps reduce inflammation and normalize immune responses by blocking the action of an enzyme called phosphodiesterase-4. This increases levels of a natural compound called cyclic AMP, which helps the body fight inflammation.

When to interrupt dosage

The prescribed amount of Daliresp is contingent upon the determined state. The quantity likewise fluctuates as per the technique of delivery outlined in the table underneath.
Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease
, 0.5 mg, 0.25 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Daliresp has one contraindication, therefore it should not be used when afflicting any of the conditions in the table below.Daliresp Contraindications
Condition
Risk Level
Notes
Liver
Do Not Combine
There are 20 known major drug interactions with Daliresp.
Common Daliresp Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Minor
Roflumilast may increase the immunosuppressive activities of 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Minor
Roflumilast may increase the immunosuppressive activities of 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Minor
Roflumilast may increase the immunosuppressive activities of Abatacept.
Abetimus
Minor
Roflumilast may increase the immunosuppressive activities of Abetimus.
Aclidinium
Minor
Roflumilast may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Daliresp Toxicity & Overdose RiskThere is no information on overdoses of roflumilast taken orally. In studies where people were given a single dose of up to 5000mcg, they experienced headaches, stomach issues, dizziness, heart palpitations, feeling faint, and low blood pressure. If someone has overdosed on roflumilast, medical assistance should be sought immediately. Dialysis is not likely to be useful since roflumilast binds to protein in the body.
image of a doctor in a lab doing drug, clinical research

Daliresp Novel Uses: Which Conditions Have a Clinical Trial Featuring Daliresp?

98 active trials are being conducted to assess the potential of Daliresp in managing Chronic Obstructive Pulmonary Disease (COPD).
Condition
Clinical Trials
Trial Phases
Chronic Obstructive Pulmonary Disease
84 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4

Daliresp Reviews: What are patients saying about Daliresp?

5Patient Review
9/26/2016
Daliresp for COPD with Chronic Bronchitis
I was on this medication for 11 days before I stopped taking it. It made me very anxious, shaky, restless, and irritable. I also lost my appetite and had thoughts of suicide. In my opinion, this drug is far too dangerous to use.
5Patient Review
7/31/2017
Daliresp for COPD with Chronic Bronchitis
The medication caused some nausea and constipation, but my doctor prescribed Zofran to help with the former. Zofran can cause constipation, so that solved that problem too! If you're experiencing similar issues, definitely talk to your doctor about trying this medication.
4.7Patient Review
6/12/2017
Daliresp for COPD with Chronic Bronchitis
I unfortunately had to discontinue using this medication due to the extremely unpleasant side effect of tremors. I also found it made me nauseous. It was very expensive, costing me $310 out of pocket. Some people may have better luck with it than I did, especially if their COPD stems more from bronchitis rather than emphysema like mine does.
4.3Patient Review
9/10/2022
Daliresp for COPD with Chronic Bronchitis
Since taking Daliresp, I haven't been hospitalized for my COPD or bronchitis. My condition seems to be stable and there's no further deterioration according to my PFTs and CT scans.
4.3Patient Review
5/11/2016
Daliresp for COPD with Chronic Bronchitis
View All Reviews
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Patient Q&A Section about daliresp

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Daliresp a steroid?

"Daliresp is not a steroid. It belongs to a class of medications called phosphodiesterase inhibitors."

Answered by AI

What does Daliresp do for COPD?

"DALIRESP is intended for use in adults with severe COPD in order to decrease the number of flare-ups or exacerbations of symptoms. It is not to be used as a bronchodilator for sudden breathing problems."

Answered by AI

What are the side effects of the medication Daliresp?

"You may experience diarrhea, weight loss, stomach/abdominal pain, nausea, loss of appetite, headache, or dizziness while taking this medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly. It is important to keep track of your weight while taking this medication."

Answered by AI

What is Daliresp used to treat?

"DALIRESP is a medicine used to prevent exacerbations of COPD in adults. It is not for treating sudden breathing problems."

Answered by AI

Clinical Trials for Daliresp

Have you considered Daliresp clinical trials? We made a collection of clinical trials featuring Daliresp, we think they might fit your search criteria.
Have you considered Daliresp clinical trials? We made a collection of clinical trials featuring Daliresp, we think they might fit your search criteria.
Have you considered Daliresp clinical trials? We made a collection of clinical trials featuring Daliresp, we think they might fit your search criteria.
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