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What is Crestor
RosuvastatinThe Generic name of this drug
Treatment SummaryRosuvastatin, also known as Crestor, is a medication used to reduce the risk of cardiovascular disease by lowering cholesterol levels in the body. It belongs to a class of drugs called statins, which block the liver's production of cholesterol. It is commonly prescribed following cardiovascular events and to people with a moderate to high risk of developing cardiovascular disease. Rosuvastatin is known to be the most potent statin drug. It is generally effective and well-tolerated with minimal side effects or long-term effects. It is also less likely to interact with other medications compared to some other statins.
Crestoris the brand name
Crestor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Crestor
Rosuvastatin
2003
441
Approved as Treatment by the FDA
Rosuvastatin, otherwise known as Crestor, is approved by the FDA for 10 uses including Hardening of the Arteries and Dysbetalipoproteinemia .Hardening of the Arteries
Helps manage Atherosclerosis
Dysbetalipoproteinemia
Hypertriglyceridemias
Coronary Artery Disease (CAD)
Helps manage Coronary Artery Disease (CAD)
Atherosclerotic Cardiovascular Diseases
Heart Disease
Dyslipidemias
Hypercholesterolemia
Homozygous Familial Hypercholesterolemia
Hyperlipidemia
Effectiveness
How Crestor Affects PatientsRosuvastatin is a drug used to lower cholesterol. It reduces total cholesterol, LDL-cholesterol, Apolipoprotein B, non-HDL-cholesterol, and triglyceride levels while increasing HDL-cholesterol levels. High LDL-cholesterol, low HDL-cholesterol, and high triglyceride levels can lead to an increased risk of atherosclerosis and cardiovascular disease. Taking rosuvastatin can reduce this risk and decrease the chances of having a major cardiovascular event such as a heart attack, stroke, or coronary death. However, there is a risk of muscle pain, liver enzyme abnormalities, and changes in
How Crestor works in the bodyRosuvastatin works by blocking an enzyme that helps create cholesterol. When this happens, the liver produces more low density lipoprotein (LDL) receptors, which help pull LDL out of the blood. This leads to a decrease in LDL and very low density lipoprotein (VLDL) in the bloodstream. Studies have also shown that rosuvastatin has additional benefits outside of just cholesterol-lowering, such as improving the stability of atherosclerotic plaques, reducing oxidative stress, and inhibiting the thrombogenic response. It also affects leukocyte trafficking and T cell activation by binding to a
When to interrupt dosage
The measure of Crestor is contingent upon the diagnosed state, such as Diet, Dysbetalipoproteinemia and Heart Disease. The amount of dosage differs, as per the procedure of administration laid out in the table below.Condition
Dosage
Administration
Hyperlipidemia
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertensive disease
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertriglyceridemias
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
cholesterol
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Homozygous Familial Hypercholesterolemia
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
diet and exercise
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Heart Disease
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertensive disease
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Dyslipidemias
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Atherosclerotic Cardiovascular Diseases
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Cardiovascular Events
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hardening of the Arteries
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Coronary Artery Disease (CAD)
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Lipid-Lowering Therapy
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Drug Combinations
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Physical Activity
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Primary Prevention of Cardiovascular Diseases
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Dysbetalipoproteinemia
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Major Adverse Cardiovascular Events
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Diet
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Warnings
Crestor ContraindicationsCondition
Risk Level
Notes
Breast Milk Production
Do Not Combine
Pulse Frequency
Do Not Combine
acute liver disease
Do Not Combine
Common Crestor Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Rosuvastatin.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Rosuvastatin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Rosuvastatin.
Carbamazepine
Major
The metabolism of Carbamazepine can be decreased when combined with Rosuvastatin.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Rosuvastatin.
Crestor Toxicity & Overdose RiskGenerally, this drug is safe to take. Common side effects may include muscle pain, constipation, exhaustion, stomach ache, and nausea. Less common side effects include damage to the muscles or liver. Asian patients may need a lower dosage to avoid toxicity, as studies show they absorb the drug more quickly than those of Caucasian descent.
Crestor Novel Uses: Which Conditions Have a Clinical Trial Featuring Crestor?
94 studies are currently examining the utility of Crestor in providing Postoperative Thromboembolism prevention, Hypertriglyceridemias management and Cardiovascular Event mitigation.Condition
Clinical Trials
Trial Phases
Hyperlipidemia
0 Actively Recruiting
Major Adverse Cardiovascular Events
0 Actively Recruiting
Diet
5 Actively Recruiting
Not Applicable
Drug Combinations
0 Actively Recruiting
Hypertriglyceridemias
0 Actively Recruiting
cholesterol
6 Actively Recruiting
Phase 3, Not Applicable
diet and exercise
0 Actively Recruiting
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Lipid-Lowering Therapy
0 Actively Recruiting
Postoperative Thromboembolism
0 Actively Recruiting
Dysbetalipoproteinemia
0 Actively Recruiting
other lipid-lowering therapies not suitable
0 Actively Recruiting
Atherosclerotic Cardiovascular Diseases
7 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Heart Disease
32 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 4, Phase 1, Early Phase 1
Hypercholesterolemia
2 Actively Recruiting
Phase 3, Not Applicable
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
Primary Prevention of Cardiovascular Diseases
0 Actively Recruiting
Hardening of the Arteries
40 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 3, Phase 2
Crestor Reviews: What are patients saying about Crestor?
5Patient Review
11/28/2021 Crestor was my third try at a statin medication, and it finally worked without any awful side effects. I take a very low dose, but it's kept my cholesterol in the normal range for about ten years now.
3.3Patient Review
10/10/2022 I developed shoulder pain a few months after starting to take Crestor 10mg. After I stopped taking the medication for a short while, the pain went away. My doctor told me to slowly start taking it again because my numbers were excellent. However, recently after going back on the medication, I've been having gastrointestinal issues and diarrhea. Has anyone else experienced this?
2.7Patient Review
3/28/2022 I developed bells palsy after just three months of taking Crestor, which my doctor had prescribed for high cholesterol. After doing some research, I found that many statin drugs are linked to causing this condition. For me, the benefits did not outweigh the risks.
2.3Patient Review
8/30/2022 After three years of taking this medication, it left me with muscle problems that required the help of a cane to walk. Once I stopped taking it, though, I was able to walk just fine within five days.
2.3Patient Review
8/25/2022 I've only been taking this medication for a short while, but the leg pain it's caused is unbearable. I may have to stop taking it as a result.
2Patient Review
7/17/2022 Crestor caused me so much pain in my knees and hips. I couldn't even walk without being in agony. Thankfully, I stopped taking it after two months. Do your research before starting any medication!
1.7Patient Review
8/15/2022 I've been experiencing a range of troubling side effects since taking this medication, including forgetting words, losing things multiple times per day, and muscle pain and weakness. I'm going to stop taking the drug today in hopes that my symptoms will improve.
1.3Patient Review
11/27/2021 I was not informed of the possible side effects of this medication. I have been taking Crestor for seven weeks and have noticed weakness in my quadriceps, fasciculations in my right leg, and increased back pain. My blood sugar has also risen with no prior history of diabetes. I stopped taking the medication nine days ago and am still waiting to see if the side effects are reversible.
1Patient Review
8/15/2022 This drug has caused me a lot of problems. I've forgotten words mid sentence, have had severe leg pain and muscle loss, and become much more irritable. My gums have also started to deteriorate; this is on top of sugar cravings and other issues. If you're considering taking this drug, please weigh the pros and cons very carefully.
1Patient Review
8/15/2022 I felt so dizzy and in pain that I could barely move. My mind was fuzzy and it was hard to communicate. The pain was unbearable. I'd rather control my ldl through diet and exercise than take this again.
1Patient Review
12/4/2021 I have been on this medication for nine months and it has caused me to be hospitalized six times. The side effects are severe dizziness, heart palpitations, high blood pressure, ankle pain, headaches, and flu-like symptoms. I stopped taking the medication and almost all of the symptoms went away. All of the doctors thought I was crazy. Do not ever take this medication!
Patient Q&A Section about crestor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the most common side effect of Crestor?
"Common side effects of Crestor include headaches, muscle aches and pains, abdominal pain, weakness, and nausea. Other side effects that have been reported include memory loss and confusion. If you experience any side effects, tell your doctor."
Answered by AI
What does Crestor do to your body?
"Rosuvastatin may also be used to prevent certain types of heart problems, and to reduce the risk of stroke and heart attack.
Rosuvastatin is used to lower bad cholesterol, raise good cholesterol, and prevent heart problems."
Answered by AI
What foods should be avoided when taking Crestor?
"Do not eat foods that are high in fat or cholesterol as it will make the rosuvastatin less effective. Do not drink alcohol as it will raise triglyceride levels and may cause liver damage. Some antacids can reduce the body's ability to absorb rosuvastatin."
Answered by AI
Should I take Crestor at night?
"You can take CRESTOR at any time of day, with or without food."
Answered by AI