Crestor

Hyperlipoproteinemia Type III, Hardening of the Arteries, Hyperlipidemia + 22 more
Treatment
16 FDA approvals
20 Active Studies for Crestor

What is Crestor

RosuvastatinThe Generic name of this drug
Treatment SummaryRosuvastatin, also known as Crestor, is a medication used to reduce the risk of cardiovascular disease by lowering cholesterol levels in the body. It belongs to a class of drugs called statins, which block the liver's production of cholesterol. It is commonly prescribed following cardiovascular events and to people with a moderate to high risk of developing cardiovascular disease. Rosuvastatin is known to be the most potent statin drug. It is generally effective and well-tolerated with minimal side effects or long-term effects. It is also less likely to interact with other medications compared to some other statins.
Crestoris the brand name
image of different drug pills on a surface
Crestor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Crestor
Rosuvastatin
2003
441

Approved as Treatment by the FDA

Rosuvastatin, otherwise known as Crestor, is approved by the FDA for 16 uses including Dysbetalipoproteinemia and Hypertriglyceridemias .
Dysbetalipoproteinemia
Hypertriglyceridemias
Coronary Artery Disease (CAD)
Helps manage Coronary Artery Disease (CAD)
Heart Disease
Heterozygous Familial Hypercholesterolemia (HeFH)
Dyslipidemias
primary Hyperlipidemia
Homozygous Familial Hypercholesterolaemia (HoFH)
Hyperlipidemia
Homozygous Familial Hypercholesterolemia
Hypertriglyceridemia
Hypercholesterolemia
Hardening of the Arteries
Helps manage Atherosclerosis
Coronary Disease
Helps manage Coronary Artery Disease (CAD)
Atherosclerotic Cardiovascular Diseases
Hyperlipoproteinemia Type III

Effectiveness

How Crestor Affects PatientsRosuvastatin is a drug used to lower cholesterol. It reduces total cholesterol, LDL-cholesterol, Apolipoprotein B, non-HDL-cholesterol, and triglyceride levels while increasing HDL-cholesterol levels. High LDL-cholesterol, low HDL-cholesterol, and high triglyceride levels can lead to an increased risk of atherosclerosis and cardiovascular disease. Taking rosuvastatin can reduce this risk and decrease the chances of having a major cardiovascular event such as a heart attack, stroke, or coronary death. However, there is a risk of muscle pain, liver enzyme abnormalities, and changes in
How Crestor works in the bodyRosuvastatin works by blocking an enzyme that helps create cholesterol. When this happens, the liver produces more low density lipoprotein (LDL) receptors, which help pull LDL out of the blood. This leads to a decrease in LDL and very low density lipoprotein (VLDL) in the bloodstream. Studies have also shown that rosuvastatin has additional benefits outside of just cholesterol-lowering, such as improving the stability of atherosclerotic plaques, reducing oxidative stress, and inhibiting the thrombogenic response. It also affects leukocyte trafficking and T cell activation by binding to a

When to interrupt dosage

The measure of Crestor is contingent upon the diagnosed state, such as Diet, Dysbetalipoproteinemia and Heart Disease. The amount of dosage differs, as per the procedure of administration laid out in the table below.
Condition
Dosage
Administration
Hyperlipoproteinemia Type III
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hardening of the Arteries
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hyperlipidemia
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Coronary Disease
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Primary Hypercholesterolemia
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Physical Activity
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Cardiovascular Events
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Diet
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
cholesterol
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Lipid-Lowering Therapy
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertensive disease
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Venous Thrombosis
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
High Cardiovascular Risk
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertriglyceridemia
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Heart Disease
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypercholesterolemia
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Major Adverse Cardiovascular Events
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertensive disease
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Dyslipidemias
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Atherosclerotic Cardiovascular Diseases
, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 5.2 mg, 20.8 mg, 41.7 mg, 10.4 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral

Warnings

Crestor Contraindications
Condition
Risk Level
Notes
Breast Milk Production
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Failure, Acute
Do Not Combine
There are 20 known major drug interactions with Crestor.
Common Crestor Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Rosuvastatin.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Rosuvastatin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Rosuvastatin.
Carbamazepine
Major
The metabolism of Carbamazepine can be decreased when combined with Rosuvastatin.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Rosuvastatin.
Crestor Toxicity & Overdose RiskGenerally, this drug is safe to take. Common side effects may include muscle pain, constipation, exhaustion, stomach ache, and nausea. Less common side effects include damage to the muscles or liver. Asian patients may need a lower dosage to avoid toxicity, as studies show they absorb the drug more quickly than those of Caucasian descent.
image of a doctor in a lab doing drug, clinical research

Crestor Novel Uses: Which Conditions Have a Clinical Trial Featuring Crestor?

94 studies are currently examining the utility of Crestor in providing Postoperative Thromboembolism prevention, Hypertriglyceridemias management and Cardiovascular Event mitigation.
Condition
Clinical Trials
Trial Phases
other lipid-lowering therapies not suitable
0 Actively Recruiting
Diet
5 Actively Recruiting
Not Applicable, Phase 1
Hypercholesterolemia
2 Actively Recruiting
Phase 1, Phase 3
Hypertensive disease
3 Actively Recruiting
Not Applicable
Coronary Disease
1 Actively Recruiting
Not Applicable
Hardening of the Arteries
21 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1
Homozygous Familial Hypercholesterolemia
1 Actively Recruiting
Phase 3
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Dyslipidemias
1 Actively Recruiting
Phase 2
Primary Prevention of Cardiovascular Diseases
1 Actively Recruiting
Not Applicable
Hyperlipoproteinemia Type III
0 Actively Recruiting
Atherosclerotic Cardiovascular Diseases
11 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Drug Combinations
0 Actively Recruiting
cholesterol
2 Actively Recruiting
Phase 3
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Primary Hypercholesterolemia
10 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Major Adverse Cardiovascular Events
0 Actively Recruiting
Hyperlipidemia
0 Actively Recruiting
Heart Disease
29 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4, Early Phase 1
diet and exercise
0 Actively Recruiting

Crestor Reviews: What are patients saying about Crestor?

5Patient Review
11/28/2021
Crestor for High Cholesterol
Crestor was my third try at a statin medication, and it finally worked without any awful side effects. I take a very low dose, but it's kept my cholesterol in the normal range for about ten years now.
3.3Patient Review
10/10/2022
Crestor for Increased Triglycerides and Cholesterol
I developed shoulder pain a few months after starting to take Crestor 10mg. After I stopped taking the medication for a short while, the pain went away. My doctor told me to slowly start taking it again because my numbers were excellent. However, recently after going back on the medication, I've been having gastrointestinal issues and diarrhea. Has anyone else experienced this?
2.7Patient Review
3/28/2022
Crestor for Treatment to Prevent a Heart Attack
I developed bells palsy after just three months of taking Crestor, which my doctor had prescribed for high cholesterol. After doing some research, I found that many statin drugs are linked to causing this condition. For me, the benefits did not outweigh the risks.
2.3Patient Review
8/30/2022
Crestor for High Cholesterol
After three years of taking this medication, it left me with muscle problems that required the help of a cane to walk. Once I stopped taking it, though, I was able to walk just fine within five days.
2.3Patient Review
8/25/2022
Crestor for High Cholesterol
I've only been taking this medication for a short while, but the leg pain it's caused is unbearable. I may have to stop taking it as a result.
View All Reviews
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Patient Q&A Section about crestor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the most common side effect of Crestor?

"Common side effects of Crestor include headaches, muscle aches and pains, abdominal pain, weakness, and nausea. Other side effects that have been reported include memory loss and confusion. If you experience any side effects, tell your doctor."

Answered by AI

What does Crestor do to your body?

"Rosuvastatin may also be used to prevent certain types of heart problems, and to reduce the risk of stroke and heart attack.

Rosuvastatin is used to lower bad cholesterol, raise good cholesterol, and prevent heart problems."

Answered by AI

What foods should be avoided when taking Crestor?

"Do not eat foods that are high in fat or cholesterol as it will make the rosuvastatin less effective. Do not drink alcohol as it will raise triglyceride levels and may cause liver damage. Some antacids can reduce the body's ability to absorb rosuvastatin."

Answered by AI

Should I take Crestor at night?

"You can take CRESTOR at any time of day, with or without food."

Answered by AI

Clinical Trials for Crestor

Have you considered Crestor clinical trials? We made a collection of clinical trials featuring Crestor, we think they might fit your search criteria.
Have you considered Crestor clinical trials? We made a collection of clinical trials featuring Crestor, we think they might fit your search criteria.
Have you considered Crestor clinical trials? We made a collection of clinical trials featuring Crestor, we think they might fit your search criteria.
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