Protein, Blueberries + Exercise for Frailty
(STRONG Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if a combination of protein supplements, blueberries, and exercise can reduce frailty and lower the risk of heart disease in older adults. Frailty accelerates aging and increases the likelihood of heart problems. The trial evaluates whether this lifestyle change can prevent heart issues and promote healthier aging. Participants will consume protein and blueberries daily and attend exercise sessions three times a week for a year. Ideal candidates are those aged 65 to 85 who have a heart disease risk factor and can engage in moderate exercise. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research on lifestyle changes that may enhance heart health and reduce frailty.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this intervention of protein, blueberries, and exercise is safe?
Research has shown that combining protein, blueberries, and exercise is generally safe for people. Studies on whey protein suggest it might boost brain health and reduce weakness without major side effects. Blueberries, rich in antioxidants, can enhance exercise performance and lower inflammation markers like IL-6 and CRP, which are linked to weakness. Exercise builds muscle and improves heart health, and it is usually safe when done in moderation. Overall, these elements are considered safe for most people, with any side effects typically being mild.12345
Why are researchers excited about this trial?
Researchers are excited about this treatment for frailty because it combines dietary supplements and exercise in a novel way to potentially improve physical health. Unlike standard frailty treatments that might focus solely on exercise or general nutrition advice, this approach delivers a specific combination of whey protein and blueberries, both known for their health benefits. Whey protein supports muscle growth and repair, while blueberries are rich in antioxidants that may reduce inflammation. Coupled with a structured exercise regimen, this treatment aims to enhance mobility and strength over a 12-month period, offering a comprehensive strategy to tackle frailty.
What evidence suggests that this trial's treatments could be effective for reducing frailty and cardiovascular disease risk?
This trial will evaluate the combination of protein, blueberries, and exercise as a treatment for frailty. Research has shown that this approach can reduce frailty by strengthening muscles, improving movement, and boosting heart health. Protein maintains muscle strength, while blueberries, rich in antioxidants, enhance blood flow and reduce inflammation. Exercise increases fitness and muscle strength, crucial for reducing frailty and improving heart health. Together, these elements support healthier aging and lower the risk of heart disease.16789
Are You a Good Fit for This Trial?
This trial is for older Nova Scotians who may be at risk of cardiovascular disease and frailty. Participants should be interested in a year-long health strategy involving diet and physical activity to improve their heart health and reduce signs of aging.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive the STRONG intervention of protein, blueberries, and exercise for 12 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Protein, Blueberries, and Exercise
Trial Overview
The study tests if adding protein, blueberries, and exercise training to the daily routines of participants can lessen frailty and lower the risk of heart disease. It's a comprehensive approach that combines these three elements over a full year.
How Is the Trial Designed?
2
Treatment groups
Active Control
treatment groups will receive the STRONG intervention of 30g/day (1 scoop) of a colorless, tasteless whey protein isolate powder supplement and 1 cup (150 grams) of blueberries per day. They will also participate in three 60-minute multimodal exercise sessions per week. Each session will include a warm-up and cool-down (\~5 minutes each), 30 minutes of moderate intensity aerobic exercise and 20 minutes of moderate intensity resistance training. The intervention lasts for 12 months.
Participants receive usual standard of care.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Nova Scotia Health Authority
Lead Sponsor
Dalhousie University, Canada
Collaborator
Published Research Related to This Trial
Citations
Study Details | NCT06693271 | Investigating the Combined ...
It is hypothesized that the addition of blueberries to a regimen of exercise plus protein will have synergistic beneficial effects on frailty and ...
Berries and Steps: a protocol of a randomized, placebo ...
We propose a study intervention protocol, which aims to determine the feasibility and preliminary efficacy of daily supplementation of freeze-dried blueberries.
3.
app.trialscreen.org
app.trialscreen.org/trials/investigating-combined-effects-protein-blueberries-exercise-on-cardiovascular-trial-nct06693271Investigating the Combined Effects of Protein, Blueberries ...
Potential benefits of participating in this study include improved cardiovascular health, reduced frailty and risk of adverse health outcomes, increased muscle ...
Effects of Protein Supplementation Combined with ...
Our findings suggest that PS plus RET as well as MET is effective in improving frailty status, lean mass, muscle strength, and physical mobility in frail older ...
Effects of Nutritional Supplementation Combined With ...
This review evaluates the effectiveness of nutritional supplementation combined with exercise training on frailty characteristics, physical function, and ...
Protein, Blueberries + Exercise for Frailty (STRONG Trial)
Trial Overview The study tests if adding protein, blueberries, and exercise training to the daily routines of participants can lessen frailty and lower the risk ...
The Impact of Whey Protein on Frailty in Older Adults ...
This pilot study aims to determine the impact of whey protein supplementation on brain antioxidant levels and to assess the effects of whey ...
Assessing the Values of Blueberries Intake on Exercise ...
Conclusion: The blueberry supplementation can potentially increase the exercise performance and decrease the IL-6 and CRP levels caused by an increased TAS ...
The Impact of Whey Protein on Frailty in Older Adults ...
Whey protein has the potential to increase brain antioxidant (GSH) levels by aiding in antioxidant synthesis. Frail older adults under-consume ...
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