Brain Imaging for Juvenile Fibromyalgia
(JFM Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study evaluates whether differences exist between adolescent females with juvenile-onset fibromyalgia and healthy controls in processing of pain and emotion at the neural level as assessed by functional magnetic resonance imaging (fMRI). The study includes a longitudinal component to evaluate changes in neural processing of pain and emotion before and after different treatment strategies.
Do I have to stop taking my current medications for the trial?
The trial requires that you have a stable medication regimen for 3 weeks before the MRI scan, so you should not change your current medications during that time. However, you cannot participate if you are taking opioid pain medication.
What safety data exists for fMRI in juvenile fibromyalgia treatment?
The provided research does not directly address the safety data of fMRI in juvenile fibromyalgia treatment. The studies focus on using fMRI to understand brain activity and pain processing in fibromyalgia patients, but they do not discuss safety outcomes or adverse effects related to the use of fMRI itself.12345
Is the treatment in the trial 'Brain Imaging for Juvenile Fibromyalgia' promising?
The treatment in the trial 'Brain Imaging for Juvenile Fibromyalgia' is promising because it uses brain imaging to better understand how pain is processed in the brain of those with juvenile fibromyalgia. This could lead to more effective ways to manage and treat pain in young people with this condition.12346
What data supports the idea that Brain Imaging for Juvenile Fibromyalgia is an effective treatment?
The available research shows that brain imaging, specifically functional MRI, helps us understand how pain is processed in the brain of those with juvenile fibromyalgia. Studies have found that adolescents with this condition experience greater pain intensity and unpleasantness compared to healthy individuals. This suggests that brain imaging can identify changes in brain activity related to pain, which might help in developing better treatments. However, the research does not directly show that brain imaging itself is an effective treatment, but rather a tool to understand the condition better.12346
Who Is on the Research Team?
Robert Coghill, PhD
Principal Investigator
Children's Hospital Medical Center, Cincinnati
Are You a Good Fit for This Trial?
This trial is for adolescent females with juvenile-onset fibromyalgia who are right-handed, have a mild disability or greater, and have been on stable medication for at least 3 weeks. They must be diagnosed by a specialist using specific criteria. Those with major psychiatric conditions, opioid use, other rheumatic diseases, or non-MRI compatible metal in their body cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Functional Magnetic Resonance Imaging (fMRI) scans to assess baseline brain activation differences in pain and emotional processing
Treatment
Participants undergo different treatment strategies such as neuromuscular training, cognitive behavioral therapy, and graded aerobic exercise
Post-treatment Assessment
fMRI scans to evaluate changes in neural processing of pain and emotion after treatment
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Functional Magnetic Resonance Imaging
Find a Clinic Near You
Who Is Running the Clinical Trial?
Children's Hospital Medical Center, Cincinnati
Lead Sponsor