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Exercise Training for Heart Failure
N/A
Recruiting
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Signs and symptoms of heart failure
signs and symptoms of heart failure
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 months
Awards & highlights
Study Summary
This trial is testing whether different types of exercise training programs can improve exercise tolerance for people with heart failure and preserved ejection fraction.
Who is the study for?
This trial is for people over 60 with heart failure who still have a decent amount of blood pumped from their heart each beat (ejection fraction > 0.50) and signs of poor relaxation of the heart muscle. They shouldn't be extremely overweight, taking certain drugs for erectile dysfunction, have severe valve disease or lung problems, very poor kidney function, or an inability to undergo MRI scans.Check my eligibility
What is being tested?
The study aims to understand why patients with HFpEF get tired easily during exercise and feel shortness of breath. It will test if specific types of exercise programs can help improve their ability to exercise without getting as tired or breathless.See study design
What are the potential side effects?
Since this trial involves exercise training programs, potential side effects may include muscle soreness, fatigue, joint pain or discomfort during physical activity. The risks are generally low but depend on individual health status.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am experiencing signs of heart failure.
Select...
I show signs or symptoms of heart failure.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 4 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Aerobic fitness
Secondary outcome measures
Cardiac fibrosis
Cardiopulmonary hemodynamics
Leg blood flow
+1 moreTrial Design
4Treatment groups
Experimental Treatment
Group I: Peripheral HFpEF whole body exerciseExperimental Treatment1 Intervention
HFpEF patients who have a peripheral limitation as the cause of the exercise intolerance randomized to whole body cycle training.
Group II: Peripheral HFpEF isolated single leg exerciseExperimental Treatment1 Intervention
HFpEF patients who have a peripheral limitation as the cause of the exercise intolerance randomized to isolated single leg training.
Group III: Central HFpEF whole body exerciseExperimental Treatment1 Intervention
HFpEF patients who have a central limitation as the cause of the exercise intolerance randomized to whole body cycle training.
Group IV: Central HFpEF isolated single leg exerciseExperimental Treatment1 Intervention
HFpEF patients who have a central limitation as the cause of the exercise intolerance randomized to isolated single leg training.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Exercise training
2019
Completed Phase 1
~1110
Find a Location
Who is running the clinical trial?
The University of Texas at ArlingtonOTHER
43 Previous Clinical Trials
4,838 Total Patients Enrolled
1 Trials studying Heart Failure
12 Patients Enrolled for Heart Failure
University of Texas-ArlingtonUNKNOWN
4 Previous Clinical Trials
650 Total Patients Enrolled
University of Texas Southwestern Medical CenterLead Sponsor
1,048 Previous Clinical Trials
1,053,635 Total Patients Enrolled
23 Trials studying Heart Failure
13,239 Patients Enrolled for Heart Failure
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- Your heart's pumping function is too high.There is clear evidence of problems with how the heart relaxes between beats.Your body mass index (BMI) is higher than 50.There is clear proof of problems with how your heart relaxes between beats.My kidney function is severely reduced.Your heart's ejection fraction is greater than 50%.I am younger than 60 years old.I am experiencing signs of heart failure.I have a serious heart valve problem.I am currently taking medication for erectile dysfunction.You cannot have an MRI for medical reasons.I have severe chronic obstructive pulmonary disease.I show signs or symptoms of heart failure.
Research Study Groups:
This trial has the following groups:- Group 1: Peripheral HFpEF isolated single leg exercise
- Group 2: Central HFpEF isolated single leg exercise
- Group 3: Central HFpEF whole body exercise
- Group 4: Peripheral HFpEF whole body exercise
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are participants aged 55+ eligible for this research trial?
"This experiment seeks to enroll patients aged 60 or above, but below 90 years of age."
Answered by AI
Are applications still being received for this experiment?
"According to clinicaltrials.gov, this medical evaluation is actively seeking participants; its original posting was on August 1st 2019 and it has been updated as recenty as May 16th 2022."
Answered by AI
How many test subjects are currently enrolled in this investigation?
"Affirmative. According to data on clinicaltrials.gov, this medical trial is in the process of recruiting participants after its initial postings from August 1st 2019 and most recent update on May 16th 2022. The research requires a maximum of 100 patients across one center."
Answered by AI
Are there any opportunities available for me to join this medical experiment?
"To fulfill the eligibility criteria set by this research trial, patients must have a diagnosis of heart failure and be between 60 to 90 years old. The team is aiming for recruitment of roughly 100 participants."
Answered by AI
Who else is applying?
What state do they live in?
Texas
What site did they apply to?
The Institute for Exercise and Environmental Medicine
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
2
Why did patients apply to this trial?
Recent research and studies
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